Abstract：
:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10 min of hypoxia followed by reoxygenation. The hypoxia-induced proteolysis was blocked by prior infusion of a newly introduced inhibitor of calpain (calpain inhibitor I, 200 microM). Together with previously published data showing improved recovery of hippocampal slices from hypoxia in the presence of calpain inhibitors, these data suggest that activation of calpain may contribute significantly to the pathophysiology of ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Arai A,Vanderklish P,Kessler M,Lee K,Lynch Gdoi
10.1016/0006-8993(91)90352-vsubject
Has Abstractpub_date
1991-08-02 00:00:00pages
276-80issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90352-Vjournal_volume
555pub_type
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