Abstract：
:The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, thereby increasing the acetylcholine concentration. In the rat diaphragm preparation, the block in neuromuscular transmission caused by diisopropyl fluorophosphate could be reversed by adding neomycin.
journal_name
Brain Resjournal_title
Brain researchauthors
Bradley RJdoi
10.1016/0006-8993(86)90098-3subject
Has Abstractpub_date
1986-09-03 00:00:00pages
397-400issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90098-3journal_volume
381pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Blink movement metrics were studied in three alert cynomolgus monkeys using electromagnetic search coils attached to the eyelids bilaterally. Monkey blinks averaged approximately 24 degrees. Down-phase peak velocities were approximately twice those of the corresponding up phases. Most blinks were symmetrical with clos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90869-o
更新日期：1993-04-23 00:00:00
abstract：:This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.03.020
更新日期：2017-06-01 00:00:00
abstract：:The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91476-4
更新日期：1987-10-27 00:00:00
abstract：:Motoneurons in the lumbar spinal cord of chick embryos 6 days old, the age when their cell death starts, were labeled in vivo by retrograde axonal transport of horseradish peroxidase (HRP) and then cultured as cord fragments or isolated cells. In Eagle's minimum essential medium with no additives, spinal cord cells su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90037-8
更新日期：1983-09-01 00:00:00
abstract：:We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02920-6
更新日期：2000-11-10 00:00:00
abstract：:An in vitro preparation was used to determine if rapidly transported radiolabeled protein which is isolated with the myelin fraction of frog sciatic nerves is similar to rapidly transported radiolabeled protein released from sciatic nerves. Sciatic nerves along with their eighth and ninth dorsal root ganglia were plac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90525-x
更新日期：1982-05-13 00:00:00
abstract：:There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.005
更新日期：2004-10-01 00:00:00
abstract：:Centrifugal fibers and their synaptic connections were studied in retinas of the lamprey Lampetra fluviatilis. The morphological analysis of retinofugal and retinopetal elements was performed after their horseradish peroxidase (HRP) filling through either the cut optic nerve in isolated retina preparations or after in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90999-2
更新日期：1989-07-24 00:00:00
abstract：:GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.033
更新日期：2006-11-06 00:00:00
abstract：:Activation of the immune system in response to either infection or lipopolysaccharide (LPS) produces neurophysiological, neuroendocrine and behavioral changes. Some of the physiological consequences of LPS are mediated by endogenous opioid peptides. The following studies were designed to characterize the effects of LP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91908-9
更新日期：1994-06-13 00:00:00
abstract：:In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90570-7
更新日期：1988-10-18 00:00:00
abstract：:The functional influence of the cholinergic input to cat dLGN has been examined by assessing the action of iontophoretically applied acetylcholine (ACh) on the visual responses of cells in layers A and A1. Iontophoretically applied pulses of ACh exerted a strong excitatory action on all 113 cells studied within these ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90059-8
更新日期：1983-12-05 00:00:00
abstract：:These experiments examined the effects, on retention, of posttraining intra-amygdala administration of norepinephrine (NE), and propranolol. Rats were trained on a one-trial step-through inhibitory avoidance task and tested for retention 24 h later. Injections were administered bilaterally (1.0 microliter/injection) t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91049-8
更新日期：1986-03-12 00:00:00
abstract：:In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02824-4
更新日期：2001-10-05 00:00:00
abstract：:A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90512-6
更新日期：1994-12-30 00:00:00
abstract：:Intracellular staining of neurons located in the superficial layers of the superior colliculus (SC) of the cat was carried out through an intracellular recording micropipette with which responses to stimulation of the optic chiasm (OX) and the optic tract (OT) ipsilateral to the explored SC were recorded. :A total of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90180-3
更新日期：1981-07-27 00:00:00
abstract：:The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.084
更新日期：2009-05-19 00:00:00
abstract：:Rhesus monkeys were taught to make identical wrist flexion and extension movements in response to either a visual cue or to vibratory cues. Changes in firing rates that were not stimulus-associated but preceded the movements were measured for each primary somatosensory cortical neuron recorded under the two stimulus c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90346-6
更新日期：1989-04-10 00:00:00
abstract：:Active substance P binding sites were solubilized from rat brain membranes by treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. About 50% of the binding activity in membrane-bound binding sites was recovered in the solubilized fraction after centrifugation at 105,000 g for 1 h. [3H]Substance P absorbed exte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91122-4
更新日期：1986-04-02 00:00:00
abstract：:In anesthetized rats, out of 48 paraventricular (PaV) and 19 periventricular (PeV) neurosecretory cells, 12 PaV and 6 PeV cells increased and 10 PaV cells decreased the electrical activities statically in response to preoptic and anterior hypothalamic warming. Four PaV and 2 PeV cells responded dynamically to the ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90036-7
更新日期：1983-12-19 00:00:00
abstract：:A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.014
更新日期：2007-12-05 00:00:00
abstract：:The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-bac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.048
更新日期：2007-06-04 00:00:00
abstract：:The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91597-0
更新日期：1994-08-29 00:00:00
abstract：:The purpose of this study was to examine mechanisms involved in the coupling of neuronal activity to cerebral blood flow (CBF). CBF was measured in rat cerebellum using laser-Doppler flowmetry during stimulus-evoked neuronal activity and related to the distribution of the extracellular field potential. Local electrica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01354-7
更新日期：1996-02-26 00:00:00
abstract：:Intrinsic versus extrinsic determinants of age-related alterations in hippocampal noradrenergic transmission were investigated using intraocular allografts in rats. Three groups of animals were examined: young hippocampal transplants in young hosts, old transplants in old hosts and young transplants in old hosts. Post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91507-2
更新日期：1989-01-30 00:00:00
abstract：:Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV). The aim of the present investigation was by chromatography combined with RIA and immunocytochemistry to determine w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91370-6
更新日期：1994-09-05 00:00:00
abstract：:The serotonin neurotoxin, 5,6-dihydroxytryptamine (5,6-DHT), was injected into the body cavity of snails. Changes induced in the central nervous system (CNS) by the neurotoxin were studied by morphological, electrophysiological and biochemical techniques for up to 90 days following injection. The neurotoxin induced a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90251-4
更新日期：1992-04-24 00:00:00
abstract：:The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91500-3
更新日期：1986-11-29 00:00:00
abstract：:The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90341-9
更新日期：1977-12-02 00:00:00
abstract：:Slow field potentials (SFP) lasting up to 5 s followed penicillin-induced bursts in CA3 of guinea pig hippocampal slices and accounted for most of the interburst interval. The longest lasting component of the SFP which was maximal in the distal apical dendritic region was usually absent in s. pyramidale. Potassium flu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90138-7
更新日期：1987-02-10 00:00:00
