Abstract：
:The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail flick response within 4 days, followed by the recovery of analgesic sensitivity one week later. After tolerance had developed, the effect of an acute systemic (1.5-4.5 mg/kg) or intrathecal (5-15 micrograms) morphine injection was determined. 'Cross-tolerance' was observed between systemic and supraspinal morphine but not between intrathecal and supraspinal morphine. The data indicate that tolerance to chronic intracerebral morphine produces the same behavioral consequences as tolerance to systemic morphine.
journal_name
Brain Resjournal_title
Brain researchauthors
Siuciak JA,Advokat Cdoi
10.1016/0006-8993(87)91476-4subject
Has Abstractpub_date
1987-10-27 00:00:00pages
311-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91476-4journal_volume
424pub_type
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