Screening and identification of dynamin-1 interacting proteins in rat brain synaptosomes.

abstract：:The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...

journal_title：Brain research

authors： Madison DV,Nicoll RA

更新日期：1988-02-23 00:00:00

abstract：:The heterogeneous nature of vesicles has been studied by evaluating exocytotic events released from the cell body of a dopamine-containing neuron of Planorbis corneus. Vesicular exocytosis has been elicited by stimulation with in situ application of elevated potassium and has been monitored electrochemically with a ca...

journal_title：Brain research

authors： Chen G,Ewing AG

更新日期：1995-12-01 00:00:00

abstract：:Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...

journal_title：Brain research

authors： Kametani F,Tanaka K,Tokuda T,Allsop D

更新日期：1995-12-12 00:00:00

abstract：:Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...

journal_title：Brain research

authors： Fernandes C,File SE,Berry D

更新日期：1996-09-23 00:00:00

abstract：:Microtubule-stabilizing drugs are useful in cancer therapy and show promise for treatment of neurodegenerative diseases. An overlapping binding site between tau and taxoid site drugs has led to a number of research papers investigating the competitive interaction between these drugs and the microtubule. This has impli...

journal_title：Brain research

authors： Das V,Miller JH

更新日期：2012-12-13 00:00:00

abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...

journal_title：Brain research

authors： Barakat I,Sensenbrenner M

更新日期：1981-06-01 00:00:00

abstract：:Several forebrain areas have been shown to project to the parabrachial nucleus (PBN) and exert inhibitory and excitatory influences on taste processing. The neurochemicals by which descending forebrain inputs modulate neural taste-evoked responses remain to be established. This study investigated the existence of soma...

journal_title：Brain research

authors： Panguluri S,Saggu S,Lundy R

更新日期：2009-11-17 00:00:00

abstract：:The analgesic effect and its mechanism of electroacupuncture (EA) on inflammatory pain, especially in the rat model of collagen-induced arthritis (CIA), have not yet been studied. This study was designed to investigate the analgesic effect and its cholinergic and serotonergic mechanism of EA in the CIA rat model. To i...

journal_title：Brain research

authors： Baek YH,Choi DY,Yang HI,Park DS

更新日期：2005-09-28 00:00:00

abstract：:The role of histamine in mediating restraint stress-induced alterations in dopaminergic neuronal activity and alpha-melanocyte-stimulating hormone (alpha MSH) secretion was evaluated in male rats. Dopaminergic neuronal activity was estimated by measuring concentrations of the dopamine metabolite 3,4-dihydroxyphenylace...

journal_title：Brain research

authors： Fleckenstein AE,Lookingland KJ,Moore KE

更新日期：1994-08-08 00:00:00

abstract：:Diazoxide (DZ), a highly selective opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has neuroprotective effects. However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. In this study, we investigated DZ attenuating neuronal los...

journal_title：Brain research

authors： Xue Y,Xie N,Lin Y,Xu J,Han Y,Wang S,Jiang H,Chi Z

更新日期：2011-04-06 00:00:00

abstract：:Cerebral cortex membranes from rats habituated to manipulations preceding decapitation (habituated rats) had 40% higher GABA binding than membranes from naive animals. Diazepam (5 X 10(-6) M), added to membranes from naive rats, increased GABA binding to the level of habituated rats, but failed to induce any further i...

journal_title：Brain research

authors： Biggio G,Concas A,Serra M,Salis M,Corda MG,Nurchi V,Crisponi C,Gessa GL

更新日期：1984-07-02 00:00:00

abstract：:Phosphorylation of cyclic AMP response element binding protein (CREB) is one of the most important mechanisms controlling various gene transcriptions. In the present study, the phosphorylation of CREB was examined immunohistochemically at 24 h of recirculation following 1.5 h of middle cerebral artery occlusion (MCAO)...

journal_title：Brain research

authors： Tanaka K,Nagata E,Suzuki S,Dembo T,Nogawa S,Fukuuchi Y

更新日期：1999-02-13 00:00:00

abstract：:Immunocytochemical and morphometric analyses were combined to demonstrate the presence of neuron subpopulations in the rat vestibular ganglion. Monoclonal antibodies reacting with neurofilament proteins (NF), calbindin-D 28K (CaBP) and calretinin (CaR) were used. Three subpopulations were identified: (1) CaBP- and CaR...

journal_title：Brain research

authors： Demêmes D,Raymond J,Atger P,Grill C,Winsky L,Dechesne CJ

更新日期：1992-06-05 00:00:00

abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...

journal_title：Brain research

authors： Kreuter J,Alyautdin RN,Kharkevich DA,Ivanov AA

更新日期：1995-03-13 00:00:00

abstract：:Influence of dopamine agonists, methamphetamine (MAT, 1 mg/kg, i.p.) and apomorphine (APO, 1 mg/kg, i.p.), on the effects of amygdaloid lesions on thresholds for the defensive attack behavior elicited by electrical stimulation of the ventromedial hypothalamic nucleus was studied in cats. The thresholds were measured i...

journal_title：Brain research

authors： Maeda H,Maki S

更新日期：1986-01-15 00:00:00

abstract：:In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...

journal_title：Brain research

authors： Su TZ,Campbell GW,Oxender DL

更新日期：1997-05-16 00:00:00

abstract：:Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...

journal_title：Brain research

authors： Toepper M,Markowitsch HJ,Gebhardt H,Beblo T,Thomas C,Gallhofer B,Driessen M,Sammer G

更新日期：2010-10-01 00:00:00

abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...

journal_title：Brain research

authors： Miletich RS,Comi G,Bankiewicz K,Plunkett R,Adams R,Di Chiro G,Kopin IJ

更新日期：1993-10-29 00:00:00

abstract：:Deacetylation is a rapid clearance mechanism for ocular melatonin. We have studied the distribution of retinal melatonin deacetylase activity among vertebrate classes. Exogenous radiolabeled melatonin is metabolized by ocular tissue prepared from the amphibian Xenopus laevis, the reptile Anolis carolinensis, the teleo...

journal_title：Brain research

authors： Grace MS,Cahill GM,Besharse JC

更新日期：1991-09-13 00:00:00

abstract：:A small, unilateral, penetrating wound was placed in the dorsolateral portion of the lumbosacral spinal cord in immature rats. Although this wound did not extend into the central canal area, some cells forming the walls of this canal underwent proliferative activity as demonstrated by [3H]thymidine autoradiography. Th...

journal_title：Brain research

authors： Gilmore SA,Leiting JE

更新日期：1980-11-10 00:00:00

abstract：:Intracellular recordings from locus coeruleus neurons grown in explant cultures reveal age-related differences in the responses to iontophoretically applied noradrenaline. Cells grown in culture for more than 26 days exhibit a simple hyperpolarizing response while cells cultured for less than 26 days often have biphas...

journal_title：Brain research

authors： Finlayson PG,Marshall KC

更新日期：1986-03-01 00:00:00

abstract：:The purpose of this paper is to investigate the involvement of various auditory localization mechanisms in the improvement of auditory spatial sensitivity in the case of partial visual deprivation. We compared sensitivity to binaural, monaural, and echo cues between normal-sighted and myopic subjects. In an auditory t...

journal_title：Brain research

authors： Després O,Candas V,Dufour A

更新日期：2005-04-11 00:00:00

abstract：:The present study gives a detailed description of the functional characteristics and of the topographic distribution of responses mediated through the climbing fiber (CF) pathway in the cerebellum of adult rats which have been repeatedly irradiated from birth so that the Purkinje cells (PCs) in the adult remained inne...

journal_title：Brain research

authors： Mariani J,Mulle C,Geoffroy B,Delhaye-Bouchaud N

更新日期：1987-09-22 00:00:00

abstract：:The kinetics of S-100 protein synthesis was studied in synchronized cultured glioma (C6) cells. The peak of the synthesis was detected at G1-phase of the cell cycle and apparently was not population density-dependent, since sparsely cultured G1-phase cells synthesized the same proportion of the protein per cell as tha...

journal_title：Brain research

authors： Fan K

更新日期：1982-04-15 00:00:00

abstract：:It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates cardiovascular effects ...

journal_title：Brain research

authors： Busnardo C,Crestani CC,Tavares RF,Resstel LB,Correa FM

更新日期：2010-07-16 00:00:00

abstract：:Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activit...

journal_title：Brain research

authors： Bouchaud C,Chollat-Namy A,Duserre S,Delamanche IS

更新日期：1994-10-17 00:00:00

abstract：:To address the question of whether fine myelinated and unmyelinated primary afferent fibers contribute to the mechanism of presynaptic inhibition in the spinal cord, we studied dorsal root-evoked dorsal root potentials (DR-DRPs) using a newly developed longitudinal spinal cord slice preparations in the adult rat. Sing...

journal_title：Brain research

authors： Shimizu T,Yoshimura M,Baba H,Shimoji K,Higashi H

更新日期：1995-09-11 00:00:00

abstract：:The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham denervation (SHAM) and then fitted with a chronic guide cannula into the lateral cerebral...

journal_title：Brain research

authors： Pires W,Wanner SP,Lima MR,Oliveira BM,Guimarães JB,de Lima DC,Haibara AS,Rodrigues LO,Coimbra CC,Lima NR

更新日期：2010-12-17 00:00:00

abstract：:Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...

journal_title：Brain research

authors： Rice AS,McMahon SB,Wall PD

更新日期：1993-12-24 00:00:00

abstract：:Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...

journal_title：Brain research

authors： Wada N,Takayama R,Kanda K,Tokuriki M

更新日期：1998-03-30 00:00:00