Abstract：
:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analgesic effect. All controls, including a simple mixture of the three components (drugs, nanoparticles, and surfactant) mixed directly before i.v. injection, exhibited no effect. Analgesia was also prevented by pretreatment with naloxone. Fluorescent and electron microscopic studies indicated that the passage of the particle-bound drug occurred by phagocytic uptake of the polysorbate 80-coated nanoparticles by the brain blood vessel endothelial cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Kreuter J,Alyautdin RN,Kharkevich DA,Ivanov AAdoi
10.1016/0006-8993(95)00023-jsubject
Has Abstractpub_date
1995-03-13 00:00:00pages
171-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00023-Jjournal_volume
674pub_type
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