Abstract：
:The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors and diarrhea compared to vehicle-treated mice. Increased concentrations of cortical adenosine A1 receptor sites, but not striatal adenosine A2a sites, were found in saturation binding studies from morphine-dependent mice. Decreases in cortical A1 agonist binding affinity values along with increases in agonist binding sites were demonstrated in competition binding studies. These results suggest that adaptive changes of upregulation and sensitization of adenosine A1 receptors play a role in mediating the opiate abstinence syndrome.
journal_name
Brain Resjournal_title
Brain researchauthors
Kaplan GB,Leite-Morris KA,Sears MTdoi
10.1016/0006-8993(94)90990-3subject
Has Abstractpub_date
1994-09-19 00:00:00pages
347-50issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90990-3journal_volume
657pub_type
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