Abstract:
:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and Purkinje cells of vermis, and at 36-38 weeks in the Purkinje cells of the cerebellar hemisphere and pontine nuclei. They then increased in number with gestational age. However, bifunctional protein-positive glia appeared early in the occipital deep white matter at 17-20 weeks of gestation, their appearance shifting from the deep to the superficial white matter with increasing age. These results suggest that bifunctional protein is closely related to neuronal maturation and gliogenesis of premyelination in the human brain during development as other peroxisomal enzymes.
journal_name
Brain Resjournal_title
Brain researchauthors
Imamura A,Kamei A,Suzuki Y,Orii T,Takashima Sdoi
10.1016/0006-8993(94)91878-3subject
Has Abstractpub_date
1994-03-21 00:00:00pages
236-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91878-3journal_volume
640pub_type
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