Developmental immunohistochemistry of bifunctional protein in human brain.


:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and Purkinje cells of vermis, and at 36-38 weeks in the Purkinje cells of the cerebellar hemisphere and pontine nuclei. They then increased in number with gestational age. However, bifunctional protein-positive glia appeared early in the occipital deep white matter at 17-20 weeks of gestation, their appearance shifting from the deep to the superficial white matter with increasing age. These results suggest that bifunctional protein is closely related to neuronal maturation and gliogenesis of premyelination in the human brain during development as other peroxisomal enzymes.


Brain Res


Brain research


Imamura A,Kamei A,Suzuki Y,Orii T,Takashima S




Has Abstract


1994-03-21 00:00:00














  • The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers.

    abstract::Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to f...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Holash JA,Stewart PA

    更新日期:1993-12-03 00:00:00

  • COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.

    abstract::We found that local perfusion of COA-Cl (0.1, 0.4, or 1.0 mM) into the dorsal striatum of living mice produced a significant and dose-dependent increase in extracellular DA levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Consistent with in vivo findings, 0.1 and 0.2 mM ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jamal M,Tsukamoto I,Takata M,Ito A,Tanaka N,Miki T,Takakura A,Ameno K,Kubota Y,Konishi R,Kinoshita H

    更新日期:2019-03-01 00:00:00

  • Evoked and event related coherence of Alzheimer patients manifest differentiation of sensory-cognitive networks.

    abstract::In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients wi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Başar E,Güntekin B,Tülay E,Yener GG

    更新日期:2010-10-21 00:00:00

  • Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats.

    abstract::The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Joó F,Tósaki A,Oláh Z,Koltai M

    更新日期:1989-06-19 00:00:00

  • The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat.

    abstract::The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vera PL,Nadelhaft I

    更新日期:1990-09-03 00:00:00

  • Restoration of rhythmic slow activity (theta) in the subcortically denervated hippocampus by fetal CNS transplants.

    abstract::Solid pieces of the fetal septal region (SG) or hippocampus (HPC) were implanted in a cavity formed by aspiration of the fimbria fornix (FF) and the overlying cingulate cortex on one side in adult rats. In other lesioned animals cell suspensions obtained from the fetal septal area (SS) or the locus coeruleus region of...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Buzsáki G,Gage FH,Czopf J,Björklund A

    更新日期:1987-01-06 00:00:00

  • Suppression of auditory nerve activity in the guinea pig cochlea by 1-(p-bromobenzoyl)-piperazine-2,3-dicarboxylic acid.

    abstract::1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Puel JL,Bobbin RP,Fallon M

    更新日期:1989-05-15 00:00:00

  • ATP-sensitive chemoreceptors: antagonism by other nucleotides and the potential implications of ectonucleotidase activity.

    abstract::As measured by extracellular single-cell recording, the responses to adenosine triphosphate (ATP) by ATP-sensitive chemoreceptors (ATP cells) on the olfactory organ of the spiny lobster are markedly suppressed by adenosine diphosphate (ADP), adenosine monophosphate (AMP) and to a lesser extent, adenosine, when each is...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gleeson RA,Carr WE,Trapido-Rosenthal HG

    更新日期:1989-09-11 00:00:00

  • Influence of non-neuronal cells on regeneration of the rat sciatic nerve.

    abstract::The ability of the rat sciatic nerve to regenerate into a previously frozen distal nerve segment was studied and compared to regeneration after a crush lesion. The regeneration rate in the frozen segment was 1.9 mm/day, which was approximately half of that observed after a crush lesion (3.3 mm/day). If an unfrozen ner...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sjöberg J,Kanje M,Edström A

    更新日期:1988-06-21 00:00:00

  • Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats.

    abstract::4-hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, a very important traditional Chinese medicinal herb, has been shown to be an effective agent against the central and peripheral nervous disorders. In this study, we attempted to explore the possible mechanisms unde...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yu SS,Zhao J,Zheng WP,Zhao Y

    更新日期:2010-01-13 00:00:00

  • Effects of sulpiride and apomorphine on prolactin release in adrenalectomized animals. Role of sodium ions.

    abstract::The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Collu R,Bouvier C

    更新日期:1987-01-13 00:00:00

  • Comparison of [125I]-bolton-hunter substance P binding in young and aged rat spinal cord.

    abstract::Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maguire CM,Geraghty DP

    更新日期:1998-03-09 00:00:00

  • Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice.

    abstract::Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro. BDNF deficiency may play a role in Parkinson's disease, as the surviving dopaminergic nigrostriatal neurons have reduced level...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baker SA,Stanford LE,Brown RE,Hagg T

    更新日期:2005-03-28 00:00:00

  • Functional significance of the apamin-sensitive conductance in rat locus coeruleus neurons.

    abstract::The effects of apamin on rat locus coeruleus (LC) neurons were studied in a brain slice preparation with intracellular recording. Bath application of apamin (2-500 nM) reduced the amplitude of an intermediate component of the afterhyperpolarization (AHP) following single spontaneous action potentials, but did not chan...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Osmanović SS,Shefner SA,Brodie MS

    更新日期:1990-10-22 00:00:00

  • Sympathoexcitatory neurons of rostral ventrolateral medulla exhibit pacemaker properties in the presence of a glutamate-receptor antagonist.

    abstract::Intracisternal (i.c.) administration of the glutamate-receptor antagonist kynurenate to halothane-anesthetized rats (paralyzed, ventilated) produced an initial hypertension associated with an increase in lumbar sympathetic nerve discharge. Kynurenate (i.c.) blocked or greatly reduced all sympathetic reflexes investiga...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sun MK,Hackett JT,Guyenet PG

    更新日期:1988-01-12 00:00:00

  • Window of opportunity: estrogen as a treatment for ischemic stroke.

    abstract::The neuroprotection research in the last 2 decades has witnessed a growing interest in the functions of estrogens as neuroprotectants against neurodegenerative diseases including stroke. The neuroprotective action of estrogens has been well demonstrated in both in vitro and in vivo models of ischemic stroke. However, ...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Liu R,Yang SH

    更新日期:2013-06-13 00:00:00

  • Reversal of learning and memory impairments following lesion of the nucleus basalis magnocellularis (NBM) by concurrent noradrenergic depletion using DSP4 in the rat.

    abstract::In the following study the behavioural effects of simultaneous lesion of the nucleus basalis magnocellularis (NBM) using ibotenic acid and noradrenergic depletion following a single i.p. administration of DSP4 (50 mg/kg) were examined in the rat. NBM lesion induced a deficit in acquisition of a reinforced T-maze alter...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Moran PM,LeMaître MH,Philouze V,Reymann JM,Allain H,Leonard BE

    更新日期:1992-11-13 00:00:00

  • Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: therapeutic time window, combination with t-PA and efficacy in aged rats.

    abstract::Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Murakami K,Suzuki M,Suzuki N,Hamajo K,Tsukamoto T,Shimojo M

    更新日期:2013-08-14 00:00:00

  • Effect of food deprivation on regional brain glucose utilization in lean and fatty Zucker rats.

    abstract::Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tsujii S,Nakai Y,Takahashi H,Usui T,Koh T,Yonekura Y,Konishi J,Imura H

    更新日期:1988-12-20 00:00:00

  • Neurotransmitter-related markers in the normal and experimentally lesioned telencephalon of the goldfish.

    abstract::The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bissoli R,Contestabile A,Marotta L,Poli A,Migani P

    更新日期:1985-10-07 00:00:00

  • Alpha 1-adrenergic agonists act on the ventromedial hypothalamus to cause neuronal excitation and lordosis facilitation: electrophysiological and behavioral evidence.

    abstract::To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kow LM,Weesner GD,Pfaff DW

    更新日期:1992-08-21 00:00:00

  • AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis.

    abstract::Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism. In this study, AMP deaminase and ADA activities of rat liver, neocortex, cerebellum, striatum and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kaminsky Y,Kosenko E

    更新日期:2010-01-22 00:00:00

  • The involvement of dopamine D2 receptors, but not D3 or D4 receptors, in the rewarding effect of brain stimulation in the rat.

    abstract::To identify the subtype of dopamine receptors critically involved in the rewarding effect of brain stimulation, four dopamine antagonists were intracranially injected in 25 rats. The importance of dopamine D1 receptors had been demonstrated previously by using SCH 23390, a highly selective D1 antagonist. Rats were imp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakajima S,Patterson RL

    更新日期:1997-06-20 00:00:00

  • Differential expression of CPD1 during postnatal development in the mouse cerebellum.

    abstract::Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Radrizzani M,Vilá-Ortiz G,Cafferata EG,Di Tella MC,González-Guerrico A,Perandones C,Pivetta OH,Carminatti H,Idoyaga Vargas VP,Santa-Coloma TA

    更新日期:2001-07-13 00:00:00

  • Functional and metabolic correlates of long series of cortical spreading depression waves in rats.

    abstract::Repetitive generation of spreading depression (SD) waves may induce metabolic and functional disturbances in the invaded brain regions. In order to better characterize this state, up to 60 SD waves were elicited in the cerebral cortex of anesthetized rats by intracortical injections of 2 microliters of isotonic K-acet...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gorelova NA,Krivánek J,Bures J

    更新日期:1987-02-24 00:00:00

  • Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract.

    abstract::The suprachiasmatic nuclei (SCN) contain the major pacemaker for mammalian circadian rhythms. The SCN receive photic input both directly, via the retinohypothalamic tract (RHT), and indirectly, via the geniculohypothalamic tract (GHT), which originates in cells in the intergeniculate leaflet (IGL) and anterior portion...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rusak B,Meijer JH,Harrington ME

    更新日期:1989-07-31 00:00:00

  • Sex difference in Onuf's nucleus homologue in the Asian musk shrew.

    abstract::Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Polak K,Freeman LM

    更新日期:2010-07-30 00:00:00

  • Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

    abstract::Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Biessels GJ,ter Laak MP,Kamal A,Gispen WH

    更新日期:2005-02-21 00:00:00

  • Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex.

    abstract::Local formation of oestrogens from androgens by aromatase cytochrome P-450 within brain cells is crucial for the sexual differentiation of the mammalian CNS. Aromatase activity has been detected in several brain regions of the developing rodent brain. In the present study, we used a mouse-specific, peptide-generated, ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Beyer C,Green SJ,Barker PJ,Huskisson NS,Hutchison JB

    更新日期:1994-02-28 00:00:00

  • Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN).

    abstract::The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system (RAS), is known to modulate waking and rapid eye movement (REM) sleep. REM sleep decreases between 10 and 30 days postnatally in the rat, with the majority occurring between 12 and 21 days. We investigated the possibility that c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Good CH,Bay KD,Buchanan R,Skinner RD,Garcia-Rill E

    更新日期:2007-01-19 00:00:00