Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity.

abstract：:We screened anti-Aβ1-42 antibodies from a human Alzheimer's disease (AD) specific single chain variable fragment (scFv) phage display library and assessed their effects in APP/PS1 transgenic mice. Reverse transcription-PCR was used to construct the scFv phage display library, and screening identified 11A5 as an anti-A...

journal_title：Brain research

authors： Wang J,Li N,Ma J,Gu Z,Yu L,Fu X,Liu X,Wang J

更新日期：2016-03-15 00:00:00

abstract：:Regional cerebral blood flow (RCBF) and local cerebral glucose utilization (LCGU) were studied in normal, awake newborn beagle puppies using quantitative autoradiography. A highly significant linear relationship between RCBF and LCGU was present for all brain structures. Special attention was directed to the subependy...

journal_title：Brain research

authors： Pasternak JF,Groothuis DR

更新日期：1984-05-14 00:00:00

abstract：:Anandamide (arachydonylethanolamide) is a naturally-occurring ligand of the canabinoid receptor. When anandamide binds to its receptor, adenylate cyclase is inhibited. At the frog neuromuscular junction, anandamide lessened the increase in quantal size produced by pretreatment in hypertonic solution. It did not alter ...

journal_title：Brain research

authors： Van der Kloot W

更新日期：1994-06-27 00:00:00

abstract：:Several neurologic illnesses in which excitotoxic mechanisms may play a role increase in prevalence with age. In the present study we examined the susceptibility of rats to quinolinic acid striatal lesions at 1, 4 and 20 months of age, and susceptibility to N-methyl-D-aspartate (NMDA) at 1 and 4 months of age. The ext...

journal_title：Brain research

authors： Finn SF,Hyman BT,Storey E,Miller JM,Beal MF

更新日期：1991-10-25 00:00:00

abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...

journal_title：Brain research

authors： Savage DD,Nadler JV,McNamara JO

更新日期：1984-12-03 00:00:00

abstract：:Mice pretreated with the benzodiazepine antagonist, CGS 8216 (2.5, 10, or 40 mg/kg, i.p.) learned a T-maze discrimination to a fixed performance criterion more rapidly than vehicle-treated mice. In retention tests conducted one week later, the drug-treated groups had better first-trial recall and greater difficulty re...

journal_title：Brain research

authors： Kumar BA,Forster MJ,Lal H

更新日期：1988-09-13 00:00:00

abstract：:Transport of fragmented DNA in apical dendrites of the CA1 pyramidal neurons of gerbil hippocampus is observed in the apoptotic process following transient forebrain ischemia. The time-course of specific DNA fragmentation was examined after the ischemic insult by in situ nick-end-labeling method and fluorescence detec...

journal_title：Brain research

authors： Hara A,Niwa M,Iwai T,Nakashima M,Yano H,Uematsu T,Yoshimi N,Mori H

更新日期：1998-09-28 00:00:00

abstract：UNLABELLED:The hypothesis that the lower midbrain, specifically in and around the retrorubral field (RRF) and/or rubrospinal tract (rs), contains a tonic inhibitory mechanism on non-shivering thermogenesis (NST) was examined in urethane-anesthetized rats. It has been proposed that removal of the tonic inhibitory mechan...

journal_title：Brain research

authors： Shibata M,Uno T,Hashimoto M

更新日期：1999-07-03 00:00:00

abstract：:Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...

journal_title：Brain research

authors： Sun Y,Waller HJ,Godfrey DA,Rubin AM

更新日期：2002-04-26 00:00:00

abstract：:The effect of an 8% casein and a control 25% casein diet on the granule cells in the dorsal blade of the dentate gyrus of the rat hippocampal formation was studied at 30, 90 and 220 days of age. Female rats were fed either an 8% or 25% casein diet 5 weeks prior to conception and the litters were maintained on these re...

journal_title：Brain research

authors： Cintra L,Díaz-Cintra S,Galván A,Kemper T,Morgane PJ

更新日期：1990-11-05 00:00:00

abstract：:Microinjection of bicuculline (Bic) into the unilateral putamen (Put) of the cat resulted in periodic occurrence of contralateral movement of the head (dystonia). Corresponding to this dystonic movement, repetitive spikes of the field potential occurring in the Put of the injected side and strong inhibition of the ext...

journal_title：Brain research

authors： Yamada H,Fujimoto K,Yoshida M

更新日期：1995-04-24 00:00:00

abstract：:The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...

journal_title：Brain research

authors： Omrani A,Fathollahi Y,Mohajerani HR,Semnanian S

更新日期：2000-09-22 00:00:00

abstract：:We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity t...

journal_title：Brain research

authors： Bohn MC,Kessler JA,Adler JE,Markey K,Goldstein M,Black IB

更新日期：1984-04-30 00:00:00

abstract：:Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...

journal_title：Brain research

authors： Zhang Q,Damian MF

更新日期：2009-06-01 00:00:00

abstract：:Upon a physiological and pharmacological challenge, the responsiveness of extracellular glutamate levels in the prefrontal cortex, ventral tegmental area and locus coeruleus were studied using microdialysis. A 10-min handling period was used as a mild stressful stimulus. In all three brain areas, handling induced an i...

journal_title：Brain research

authors： Timmerman W,Cisci G,Nap A,de Vries JB,Westerink BH

更新日期：1999-07-03 00:00:00

abstract：:The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...

journal_title：Brain research

authors： Matsushita K,Kitagawa K,Matsuyama T,Ohtsuki T,Taguchi A,Mandai K,Mabuchi T,Yagita Y,Yanagihara T,Matsumoto M

更新日期：1996-12-16 00:00:00

abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...

journal_title：Brain research

authors： Baum L,Masliah E,Iimoto DS,Hansen LA,Halliday WC,Saitoh T

更新日期：1992-02-21 00:00:00

abstract：:Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...

journal_title：Brain research

authors： Roberts E,Bologa L,Flood JF,Smith GE

更新日期：1987-03-17 00:00:00

abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...

journal_title：Brain research

authors： Sakai K,Crochet S

更新日期：2001-04-20 00:00:00

abstract：:Luteinizing hormone (LH) secretion during the reproductive cycle and in ovariectomized (OVX) rats is pulsatile and this pattern of secretion is determined by intermittent discharges of LH-releasing hormone (LHRH) into the hypophysial portal vessels. LHRH secretion is probably controlled by prior pulsatile norepinephri...

journal_title：Brain research

authors： Anselmo-Franci JA,Rocha-Barros VM,Franci CR,McCann SM

更新日期：1999-06-26 00:00:00

abstract：:The study examined whether intravenous (i.v.) leptin increased Fos-production in spinally projecting neurons in the hypothalamic paraventricular nucleus (PVN). We combined (i) rhodamine tagged microspheres injected into the upper thoracic spinal cord and (ii) Fos (marker of neuronal activation) immunohistochemistry. E...

journal_title：Brain research

authors： Badoer E,Ryan A

更新日期：1999-10-09 00:00:00

abstract：:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...

journal_title：Brain research

authors： Takemoto Y,Semba R

更新日期：2006-02-16 00:00:00

abstract：:The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...

journal_title：Brain research

authors： Peters S,Kreulen DL

更新日期：1984-06-11 00:00:00

abstract：:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a ...

journal_title：Brain research

authors： Wang CX,Yang T,Shuaib A

更新日期：2003-02-14 00:00:00

abstract：:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...

journal_title：Brain research

authors： Sawchenko PE

更新日期：1987-12-29 00:00:00

abstract：:This study was conducted on unanesthetized rainbow trout equipped with two ECG electrodes and with an intracerebroventricular (i.c.v.) micro-guide. The ECG signal was recorded during three experimental sessions of 30 min and the heart rate variability (HRV) spectral analysis was performed during stabilized periods of ...

journal_title：Brain research

authors： Le Mével JC,Mimassi N,Lancien F,Mabin D,Boucher JM,Blanc JJ

更新日期：2002-08-23 00:00:00

abstract：:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In al...

journal_title：Brain research

authors： Zukin SR,Brady KT,Slifer BL,Balster RL

更新日期：1984-02-27 00:00:00

abstract：:NK1 receptor antagonists have been shown to act centrally and to produce a broad-spectrum anti-emetic action. To determine precisely the site of this action, we microinjected GR205171, an NK1 receptor antagonist, into the left medulla oblongata in decerebrate paralyzed dogs. The right medulla was transected 2.5 mm ros...

journal_title：Brain research

authors： Fukuda H,Nakamura E,Koga T,Furukawa N,Shiroshita Y

更新日期：1999-02-13 00:00:00

abstract：:We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...

journal_title：Brain research

authors： Honma Y,Yamakage M,Ninomiya T

更新日期：1999-06-19 00:00:00

abstract：:Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing ...

journal_title：Brain research

authors： Husain FT,Akrofi K,Carpenter-Thompson JR,Schmidt SA

更新日期：2015-09-16 00:00:00