Abstract：
:Anandamide (arachydonylethanolamide) is a naturally-occurring ligand of the canabinoid receptor. When anandamide binds to its receptor, adenylate cyclase is inhibited. At the frog neuromuscular junction, anandamide lessened the increase in quantal size produced by pretreatment in hypertonic solution. It did not alter the increases in quantal size produced by insulin or by a permeable agonist of cAMP. It was known that hypertonic treatment increases quantal size by way of the cAMP-protein kinase A pathway. Anandamide had no effect on miniature endplate potential frequency (fmepp) in untreated preparations. After fmepp was increased in the presence of a permeable cAMP agonist, anandamide brought fmepp back to resting levels. The conclusions are that the motor nerve terminal has a cannabinoid receptor. The binding of anandamide to this receptor seems to block adenylate cyclase.
journal_name
Brain Resjournal_title
Brain researchauthors
Van der Kloot Wdoi
10.1016/0006-8993(94)91062-6subject
Has Abstractpub_date
1994-06-27 00:00:00pages
181-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91062-6journal_volume
649pub_type
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