Abstract：
:NK1 receptor antagonists have been shown to act centrally and to produce a broad-spectrum anti-emetic action. To determine precisely the site of this action, we microinjected GR205171, an NK1 receptor antagonist, into the left medulla oblongata in decerebrate paralyzed dogs. The right medulla was transected 2.5 mm rostral to the obex to eliminate the emetic function of that half. Fictive retching induced by vagal stimulation was still observed after each of 32 injections (0.5-5 microgram in 1-30 microliter) in the area ventrolateral to the solitary complex in six dogs. Retching was also observed for 30 min or more after all but 2 of 30 injections (0.5-1 microgram in 0.5-1 microliter) in the area dorsal to the retrofacial nucleus in 17 dogs. In contrast, retching disappeared within 5-30 min after each of 20 injections (0.5-1 microgram in 1 microliter) in the area adjacent to the semicompact part of the nucleus ambiguus (scAMB) in 15 dogs. The threshold dose for abolition of the retching response was examined in seven dogs and was about 0.1 ng in 1 microliter. The maximum velocity of salivation occurred before the onset of retching and significantly decreased after its abolition. These results suggest that the site of the anti-emetic action of NK1 receptor antagonists may lie in a limited area adjacent to the scAMB, and that neurons in the site induce prodromal signs and retching in a sequential manner.
journal_name
Brain Resjournal_title
Brain researchauthors
Fukuda H,Nakamura E,Koga T,Furukawa N,Shiroshita Ydoi
10.1016/s0006-8993(98)01324-9subject
Has Abstractpub_date
1999-02-13 00:00:00pages
439-49issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01324-9journal_volume
818pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The stress-related neurohormone, corticotropin-releasing factor (CRF), also acts as a neurotransmitter to activate the brain noradrenergic nucleus, locus coeruleus (LC). Previous electrophysiological findings demonstrating that tonic CRF secretion in the LC is increased in adrenalectomized rats suggest that activity o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00900-7
更新日期：1999-01-16 00:00:00
abstract：:Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.04.014
更新日期：2019-08-15 00:00:00
abstract：:Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.008
更新日期：2015-04-24 00:00:00
abstract：:Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.062
更新日期：2008-01-29 00:00:00
abstract：:In this paper the response of cerebral phosphate metabolism to mild hypoxia in young, medium and old rats has been studied via in-vivo [31P]nuclear magnetic resonance (NMR). It was found that the young adults (5-6 months) were more sensitive to this mild stress than either the mature adult (11-12 months) or senescent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90536-2
更新日期：1989-03-13 00:00:00
abstract：:The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old. On average, C57BL/6J (35 to 190 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.066
更新日期：2006-05-26 00:00:00
abstract：:Anterograde and retrograde tracing experiments employing WGA-HRP were used to identify an auditory projection area within the frontal telencephalon of the pigeon. The projection originates in a nucleus of the lateral lemniscus, travels with the quintofrontal tract and terminates within nucleus basalis. The location of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91499-x
更新日期：1986-11-29 00:00:00
abstract：:The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90098-3
更新日期：1986-09-03 00:00:00
abstract：:The purpose of this study was to investigate the cannabinoid and opioid mediated regulation on the effects of central Delta(9)-tetrahydrocannabinol (Delta(9)-THC) administration on hypothalamus-pituitary-adrenal (HPA) axis activity in the male rat. Intracerebroventricular (i.c.v.) administration of delta(9)-THC (25, 5...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01756-4
更新日期：1999-08-21 00:00:00
abstract：:Neurons are distinctive in that they are generally considered to be permanently post-mitotic cells. The oncoprotein p53 is a key regulator in neuronal development, notably in cell proliferation and neuronal death. We hypothesize that p53 maintains the post-mitotic characteristic of differentiated neurons. New lines of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04119-7
更新日期：2003-03-07 00:00:00
abstract：:The presence of an adrenergic projection from the nucleus of the tractus solitarius (NTS) to the parabrachial nucleus (PB) was demonstrated by the immunocytochemistry combined with a retrograde tracing method. Numerous neurons containing both phenylethanolamine N-methyltransferase, a marker for adrenaline, and wheat g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90654-3
更新日期：1988-09-06 00:00:00
abstract：:Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91273-j
更新日期：1990-01-08 00:00:00
abstract：:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02919-0
更新日期：2002-08-23 00:00:00
abstract：:In the present report the effects of postpuberal gonadectomy on vomeronasal organ (VO) morphology were studied. Postpuberal gonadectomy induced in both male and female rats a decrement in the height of the epithelium and in the nuclear size of the bipolar neurons. These results show that the maintenance of neurosensor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90315-8
更新日期：1984-06-01 00:00:00
abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90274-9
更新日期：1984-12-03 00:00:00
abstract：:The development of the endothelial system of the rat cerebellum was studied by immunohistochemical techniques with two antibodies specific of two membrane antigens characteristic of 'mature' endothelial cells. It appears that the maturation of endothelial cells is very late in the rat cerebellum. This absence of a ful...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90149-x
更新日期：1985-01-01 00:00:00
abstract：:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91050-7
更新日期：1981-10-19 00:00:00
abstract：:Estrogen receptor α (ERα) isoforms with complex types of alternative splicing are naturally present in the human brain and may affect canonical receptor signaling. In the present study we investigated transcriptional activity of common ERα splice variants from this group with different molecular defects: MB1 (intron r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.12.050
更新日期：2013-03-15 00:00:00
abstract：:In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90161-4
更新日期：1975-12-26 00:00:00
abstract：:Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.074
更新日期：2005-07-05 00:00:00
abstract：:Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90919-3
更新日期：1984-08-06 00:00:00
abstract：:Impaired learning has been shown as a consequence of isolation-rearing in a variety of paradigms. However, there are situations in which learning in isolation-reared rats is enhanced or unimpaired compared to socially reared rats. The present experiments investigated the effects of isolation rearing on place navigatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01578-7
更新日期：1996-04-09 00:00:00
abstract：:The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostate sections from post mortem specimens of human spinal cord and lower medulla oblongata was studied by quantitative autoradiographic methods using [125I]YLFQPQRFamide as ligand. Samples were taken from five cases who had died with no hist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91531-8
更新日期：1994-01-07 00:00:00
abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91218-h
更新日期：1993-04-30 00:00:00
abstract：:Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00904-3
更新日期：1996-11-25 00:00:00
abstract：:Mutant Cu/Zn superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) causes selective motor neuron loss through unknown mechanisms of cell damage. Damaged neurons frequently undergo apoptosis mediated by the p53 cell survival regulator. We therefore studied whether motor neuron diseas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02745-1
更新日期：2000-10-06 00:00:00
abstract：:Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01783-7
更新日期：1999-09-11 00:00:00
abstract：:During embryogenesis, transient expression of nestin in proliferating neuroepithelial stem cells signals the commitment of progenitor cells to differentiate. Although adult mammalian brain contains very little nestin, significant upregulation of nestin has been reported following cerebral injury, leading to speculatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.070
更新日期：2004-05-22 00:00:00
abstract：:Cajal-Retzius (CR) cells of the mammalian neocortex co-express the extracellular matrix protein Reelin and p73, a transcription factor involved in cell death and survival. Most neocortical CR cells derive from the cortical hem, with minor additional sources. We analyzed the distribution of Reelin and p73 immunoreactiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.015
更新日期：2007-02-09 00:00:00
abstract：:Benzodiazepine binding sites are present on gamma-aminobutyric acid (GABA) receptors in hippocampal neurons. Diazepam is known to potentiate the amplitude and prolong the decay of GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs). In this study, benzodiazepine involvement in long-term potentiation (LT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.008
更新日期：2005-11-16 00:00:00
