Cycloheximide activation of the lordotic response in low-dose, estrogen-treated ovariectomized rats: evidence for modulating inhibitory influences of the limbic system on sexual behavior.

Abstract:

:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microliter saline) or 0.5 microliter saline was injected into the lateral septum (LS), cortical nucleus (ACO) or medial nucleus of the amygdala or medial preoptic area on day 11 after OVX. The dose of EB was insufficient to facilitate lordotic behavior on day 10 or day 12 after OVX unless CHX was injected into the LS or ACO. Injection of saline did not influence lordosis.

journal_name

Brain Res

journal_title

Brain research

authors

Renner KJ,Bast JD,Purcell ES,Quadagno DM

doi

10.1016/0006-8993(81)91050-7

subject

Has Abstract

pub_date

1981-10-19 00:00:00

pages

432-6

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)91050-7

journal_volume

222

pub_type

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