Abstract:
:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us to confirm the presynaptic nature of the depression of synaptic transmission during hypoxia. We tested the hypothesis that activation of heterosynaptic inhibitory receptors localized in glutamatergic presynaptic terminals in the hippocampus, namely gamma-aminobutyric acid subtype B (GABA(B)) receptors, alpha(2)-adrenergic receptors, and muscarinic receptors might contribute to the hypoxia-induced depression of synaptic transmission. Field excitatory postsynaptic potentials were recorded in the CA1 area of hippocampal slices from young adult (5-6 weeks) Wistar rats. Neither the selective antagonist for alpha(2)-adrenergic receptors, rauwolscine (10 microM), nor the antagonist for the GABA(B) receptors, CGP 55845 (10 microM), modified the response to hypoxia. The selective adenosine A(1) receptor antagonist, DPCPX (50 nM), reduced the hypoxia-induced depression of synaptic transmission to 59.2+/-9.6%, and the muscarinic receptor antagonist, atropine (10 microM), in the presence of DPCPX (50 nM), further attenuated the depression of synaptic transmission to 49.4+/-8.0%. In the same experimental conditions, in the presence of DPCPX (50 nM), the muscarinic M(2) receptor antagonist AF-DX 116 (10 microM), but not the M(1) receptor antagonist pirenzepine (1 microM), also attenuated the hypoxia-induced depression to 41.6+/-6.6%. Activation of muscarinic M(2) receptors contributes to the depression of synaptic transmission upon hypoxia. This effect should assume particular relevance during prolonged periods of hypoxia when other mechanisms may become less efficient.
journal_name
Brain Resjournal_title
Brain researchauthors
Coelho JE,de Mendonça A,Ribeiro JAdoi
10.1016/s0006-8993(00)02381-7subject
Has Abstractpub_date
2000-06-30 00:00:00pages
158-65issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02381-7journal_volume
869pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Unilateral olfactory nerve section was performed in the mouse. Three biochemical markers of the olfactory chemoreceptor neurons: carnosine, carnosine synthetase activity and the olfactory marker protein, were measured in the olfactory bulb and epithelium. Parallel observations were made by light microscopy as well as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90703-x
更新日期:1977-08-19 00:00:00
abstract::A double-staining immunocytochemical study was done in ovariectomized (OVX) female rats that were either treated with 17beta-estradiol (E(2)) (OVX+E(2)) to produce an approximate circulating level of 30 pg/ml plasma, or not-treated with E(2) (OVX), to investigate the distribution of subfornical organ (SFO) neurons tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01672-8
更新日期:1999-08-07 00:00:00
abstract::The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90708-4
更新日期:1991-08-30 00:00:00
abstract::Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90490-x
更新日期:1981-06-29 00:00:00
abstract::The morphology of so-called interplexiform (IP) cells immunoreactive to tyrosine hydroxylase (TH) or somatostatin (SOM) in the rat retina was described in comparison with those in the carp retina. In frozen cross-sections of the rat retina, many processes of TH-like immunoreactive cells were found to extend toward the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91103-5
更新日期:1985-10-28 00:00:00
abstract::In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.02.029
更新日期:2018-05-15 00:00:00
abstract::Five normal rats and four rats with bilateral lesions of auditory cortex were tested by the conditioned suppression procedure to determine their abilities to discriminate between spatially separated sound sources. The discrimination involved detection of a change in location of a train of clicks from a speaker on the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90865-x
更新日期:1978-04-28 00:00:00
abstract::Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02297-1
更新日期:2001-05-11 00:00:00
abstract::2-Deoxy-d-glucose (2DG) is a glucose analogue that inhibits intracellular utilization of glucose and produces a characteristic behavioral response known as glucoprivic feeding. The area postrema (AP) is a caudal hindbrain structure shown previously to be involved in 2DG-induced glucoprivic feeding. In addition, periph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00528-9
更新日期:1998-08-10 00:00:00
abstract::Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.09.014
更新日期:2015-11-19 00:00:00
abstract::The contribution of neurons in the nucleus medianus (NM) in mediating the drinking and pressor responses elicited by administration of angiotensin II (AII) either directly into the subfornical organ (SFO) or intravenously was investigated in conscious, unrestrained rats. Microinjection of AII into the SFO elicited a r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90692-6
更新日期:1989-05-29 00:00:00
abstract::Retinal and tectal potentials to alternating gratings were recorded in pigeons raised monocularly deprived. Deprived eyes showed consistent myopia and anterior-posterior axis elongation. In addition, vitreal opacities were observed in 70% of the deprived eyes. In pigeons with vitreal opacities, a reduction of retinal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90165-9
更新日期:1985-07-15 00:00:00
abstract::We have developed a novel imaging system "real-time bioradiography", which is able to estimate the dynamic changes of physiological function and metabolism in living tissues using positron emitter-labeled tracers and chemiluminescence probes. The apparatus is comprised of a photon-counting camera, image-controller, cu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.034
更新日期:2006-03-10 00:00:00
abstract::It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91137-p
更新日期:1991-05-10 00:00:00
abstract::We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01499-7
更新日期:1999-06-19 00:00:00
abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146968
更新日期:2020-11-01 00:00:00
abstract::The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal exc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.068
更新日期:2007-03-23 00:00:00
abstract::The uptake of amino acids into slices of adult and newborn mouse brain was studied in relation to Na+ flow. (1) The level of Na+ and K+ incubated slices of brain depends on the ionic composition of the incubation medium. The intracellular levels of Na+ in adult tissue are below, in fetal tissue above, Na+ levels in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90763-5
更新日期:1975-02-14 00:00:00
abstract::Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.12.025
更新日期:2016-06-01 00:00:00
abstract::Abnormal increase in native long-chain ceramides (lcCer) in AD implicates roles in neuronal atrophy and cognitive dysfunction especially in view of divergent roles this second messenger plays in cell function. Since clearance is mediated by glucosylceramide synthase (GCS, EC 2.4.1.80) levels of the enzyme were compare...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.066
更新日期:2008-01-29 00:00:00
abstract::The effect of microinfusions of cholecystokinin octapeptide (CCK8) and its antagonist L364,718 on duodenal and jejunal motility were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the duodeno-jejunal wall. Steel cannulas were placed bilaterally in ei...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91124-y
更新日期:1990-01-29 00:00:00
abstract::We have examined the role of the octopamine-containing buccal OC interneuron in the fictive feeding rhythm generated by depolarizing a modulatory interneuron, SO, in the isolated central nervous system (CNS) of Lymnaea stagnalis. Before stimulating the SO, the initial fictive feeding rate was 2.0+/-0.37 bites/min (mea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02968-1
更新日期:2000-12-22 00:00:00
abstract::α4βδ GABA(A) receptors (GABARs) have low CNS expression, but their expression is increased by 48h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one). THP also increases the efficacy of δ-containing GABARs acutely, where GABA is a partial agonist. Thus, we examined effects of THP (100 nM) and full GABA agoni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.047
更新日期:2012-06-29 00:00:00
abstract::A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90415-8
更新日期:1990-02-05 00:00:00
abstract::We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00674-x
更新日期:1998-08-31 00:00:00
abstract::Unit activity of locus coeruleus (LC) neurons in rats was investigated. After the animal recovered from anesthesia, the spontaneous activity exhibited periodic bursting discharges at about 15-30 s intervals. The oscillation was observed to last for a long time (1-3 h). It is suggested that many LC neurons exhibited th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90540-6
更新日期:1982-05-13 00:00:00
abstract::A pathway from the pretectal region to the dorsal division of the lateral geniculate body has been studied by autoradiography in adult cats following injection of tritium-labeled amino acids into the meso-diencephalic border zone. The findings suggest that the pretecto-geniculate connection arises in the ipsilateral n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90861-6
更新日期:1980-08-11 00:00:00
abstract::Glial-cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN) and persephin (PSPN), known as the GDNF family ligands (GFLs), influence the development, survival and differentiation of cultured dopaminergic neurons from ventral mesencephalon (VM). Detailed knowledge about the effects of GFLs on o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.056
更新日期:2006-01-19 00:00:00
abstract::Acute and repeated exposure to cocaine induces long-lasting alterations in neural networks that underlie compulsive drug seeking and taking. Cocaine exposure triggers complex adaptations in the brain that are mediated by dynamic patterns of gene expression that are translated into enduring changes. Recently, epigeneti...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.09.069
更新日期:2015-12-02 00:00:00
abstract::This study presents a three-dimensional analysis of pallido-thalamic axons and axonal endings in the monkey (Macaca mulatta and M. irus). Injections of the anterograde tracer biocytin were made in the dorsal, associative region of the medial pallidum. Numerous axonal endings were observed within the pallidal territory...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00181-9
更新日期:1997-04-18 00:00:00