Effects of olfactory bulbectomy on NMDA receptor density in the rat brain:.

Abstract:

:Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats were correlated with discrete regional effects on NMDA receptor function measured using a [3H] MK-801 binding assay. Irritability scores, measured before and for 2 weeks after OBX, showed a gradual increase in irritability after OBX. A reduction of the NMDA receptor density was observed in the cerebral cortex and amygdala 16 days after OBX, but not in the striatum, olfactory tubercle, entorhinal cortex, and hippocampus. These results demonstrate that OBX causes changes in the NMDA receptor system in certain brain regions and suggest that these changes may be responsible for the behavioral deficits of OBX rats.

journal_name

Brain Res

journal_title

Brain research

authors

Ho Y,Liu T,Tai M,Wen Z,Chow RS,Tsai Y,Wong C

doi

10.1016/s0006-8993(01)02297-1

subject

Has Abstract

pub_date

2001-05-11 00:00:00

pages

214-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006899301022971

journal_volume

900

pub_type

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