Effects of olfactory bulbectomy on NMDA receptor density in the rat brain:.

abstract：:Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1984-03-19 00:00:00

abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...

journal_title：Brain research

authors： Singh R,Ticku MK

更新日期：1985-12-09 00:00:00

abstract：:The short and long-term effects of systemic administration of kainic acid to immature animals were studied in rats. Kainic acid was administered systemically to rats of 1-30 days of age. The rats were monitored for both behavioral and EEG changes. To study the effects of kainic acid on seizure susceptibility, status e...

journal_title：Brain research

authors： Holmes GL,Thompson JL

更新日期：1988-03-01 00:00:00

abstract：:The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations...

journal_title：Brain research

authors： Pohorecki R,French J,Domino EF

更新日期：1987-09-08 00:00:00

abstract：:Recent work in our laboratory has demonstrated that spontaneous or evoked climbing fiber inputs are associated with an increased responsiveness of Purkinje cells to mossy fiber inputs activated by natural peripheral stimuli. These experiments were designed to test the hypothesis that this increased responsiveness occu...

journal_title：Brain research

authors： Ebner TJ,Bloedel JR

更新日期：1984-08-20 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older ...

journal_title：Brain research

authors： Van Ness PC,Olsen RW,Verity MA

更新日期：1989-12-18 00:00:00

abstract：:Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...

journal_title：Brain research

authors： Mattis VB,Svendsen CN

更新日期：2017-02-01 00:00:00

abstract：:Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...

journal_title：Brain research

authors： Matsuyama K,Ohta Y,Mori S

更新日期：1988-09-13 00:00:00

abstract：:The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly redu...

journal_title：Brain research

authors： Geiger JD

更新日期：1986-01-22 00:00:00

abstract：:Using [3H]para-aminoclonidine, alpha 2 adrenergic binding sites have been mapped in the rat and human CNS using in vitro labeling autoradiographic techniques. In both the rat and human thoracic spinal cord, high densities of alpha 2 binding sites were associated with the substantia gelatinosa and the intermediolateral...

journal_title：Brain research

authors： Unnerstall JR,Kopajtic TA,Kuhar MJ

更新日期：1984-03-01 00:00:00

abstract：:The microdialysis technique was utilized to study the effects of N-methyl-D-aspartate (NMDA) receptor ligands on the in vivo release of endogenous glutamate (Glu) and aspartate (Asp) from the rat striatum. Addition of NMDA (250 and 500 microM) to the dialysis perfusion solution resulted in a striking dose-dependent in...

journal_title：Brain research

authors： Bustos G,Abarca J,Forray MI,Gysling K,Bradberry CW,Roth RH

更新日期：1992-07-10 00:00:00

abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...

journal_title：Brain research

authors： Ando M,Kato T,Tanaka R,Nagata Y

更新日期：1986-05-14 00:00:00

abstract：:We analyzed flotillin-1 expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that flotillin-1 expression increased significantly in the spinal cords from rats at the peak stage of EAE compared with the levels in control animals (p<0.05) and dec...

journal_title：Brain research

authors： Kim H,Ahn M,Moon C,Matsumoto Y,Sung Koh C,Shin T

更新日期：2006-10-09 00:00:00

abstract：:Phrenic afferents are capable of attenuating the phrenic motor response elicited by the intercostal-to-phrenic excitatory reflex in decerebrate, paralyzed cats. High spinal transection eliminates the attenuating effect of the bilateral phrenic-to-phrenic inhibitory reflex. These results indicate that although phrenic ...

journal_title：Brain research

authors： Speck DF

更新日期：1987-06-23 00:00:00

abstract：:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...

journal_title：Brain research

authors： Renner KJ,Bast JD,Purcell ES,Quadagno DM

更新日期：1981-10-19 00:00:00

abstract：BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...

journal_title：Brain research

authors： Griesmaier E,Schlager G,Wegleiter K,Hermann M,Urbanek M,Simbruner G,Keller M

更新日期：2010-10-08 00:00:00

abstract：:In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...

journal_title：Brain research

authors： Greenstein YJ,Pavlides C,Winson J

更新日期：1988-01-12 00:00:00

abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...

journal_title：Brain research

authors： Xian CJ,Huang BR,Zhou XF

更新日期：1999-07-24 00:00:00

abstract：:The neurite promoting factors in the astroglial conditioned medium (As-CM) were characterized by using primary cultures of embryonic rat neocortical neurons. The factors in the As-CM bind to lectins such as wheat germ agglutinin (WGA), suggesting that they contain sugar moieties. When the WGA-bound fractions were appl...

journal_title：Brain research

authors： Mori T,Iijima N,Kitabatake K,Kohsaka S

更新日期：1990-09-10 00:00:00

abstract：:Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebra...

journal_title：Brain research

authors： Candelario-Jalil E,González-Falcón A,García-Cabrera M,León OS,Fiebich BL

更新日期：2004-05-08 00:00:00

abstract：:Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-L...

journal_title：Brain research

authors： McNamara MJ,Ruff CT,Wasco W,Tanzi RE,Thinakaran G,Hyman BT

更新日期：1998-08-31 00:00:00

abstract：:Electrical stimulation of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate recurrent inhibition in cells in the nucleus of the solitary tract (NTS, the first central relay in the gustatory system). Here, we explored the relationship between inhibitory circuits and the br...

journal_title：Brain research

authors： Rosen AM,Di Lorenzo PM

更新日期：2009-06-12 00:00:00

abstract：:Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIA...

journal_title：Brain research

authors： Min-Chu L,Mackenna BR,Watt JA

更新日期：1981-03-23 00:00:00

abstract：:Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A lin...

journal_title：Brain research

authors： Martinez M,Hernández AI,Martínez N,Ferrándiz ML

更新日期：1996-08-26 00:00:00

abstract：:The mesolimbic dopamine (DA) system has long been known to be involved in reward behaviors. As with other substances of abuse, it has been extensively reported that ethanol influences the dopaminergic system. The present study examined whether selectively bred Sardinian-alcohol-preferring (sP) and Sardinian alcohol no...

journal_title：Brain research

authors： Casu MA,Colombo G,Gessa GL,Pani L

更新日期：2002-01-11 00:00:00

abstract：:The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all lami...

journal_title：Brain research

authors： Gouardères C,Tafani JA,Meunier JC,Jhamandas K,Zajac JM

更新日期：1999-08-14 00:00:00

abstract：:The roles of endogenous serotonin (5-HT) and 5-HT receptor subtypes in regulation of acetylcholine (ACh) release in frontal cortex of conscious rats were examined using a microdialysis technique. Systemic administration (1 and 3 mg/kg, i.p.) of the 5-HT-releasing agent p-chloroamphetamine (PCA) elevated ACh output in ...

journal_title：Brain research

authors： Yamaguchi T,Suzuki M,Yamamoto M

更新日期：1997-10-24 00:00:00

abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...

journal_title：Brain research

authors： Maccari S,Piazza PV,Deminière JM,Angelucci L,Simon H,Le Moal M

更新日期：1991-05-10 00:00:00

abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...

journal_title：Brain research

authors： Reith CA,Sillar KT

更新日期：1997-10-03 00:00:00

abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

journal_title：Brain research

authors： Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

更新日期：2015-05-22 00:00:00