Abstract：
:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relation between individual differences in amphetamine self-administration and characteristics of hippocampal corticosteroid receptors. Rats were selected on the basis of likelihood to self-administer amphetamine and designed as: (1) High Responding (HR) rats, who quickly acquire the response and (2) Low Responding (LR), who fail to self-administer amphetamine. We found lower affinities both for hippocampal type I and type II corticosteroid receptors in the HR animals. These data suggest that modification of hippocampal corticosteroid receptors may be responsible for the predisposition of some animals for amphetamine self-administration. Because HR rats also show a greater behavioral and endocrinological response in a novel environment, these differences in affinities suggest a relation among amphetamine self-administration, control of the corticosterone feedback loop, serum levels of corticosterone and characteristics of hippocampal corticosteroid receptors. The implication is that pharmacological manipulations of corticosteroid receptors may reveal new therapeutic strategies for drug abuse.
journal_name
Brain Resjournal_title
Brain researchauthors
Maccari S,Piazza PV,Deminière JM,Angelucci L,Simon H,Le Moal Mdoi
10.1016/0006-8993(91)91137-psubject
Has Abstractpub_date
1991-05-10 00:00:00pages
305-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91137-Pjournal_volume
548pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.03.021
更新日期：2019-04-15 00:00:00
abstract：OBJECTIVE:The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions. METHOD:EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146743
更新日期：2020-05-15 00:00:00
abstract：:Microglial reactivity in the red nucleus of rats was studied following upper cervical and lower thoracic rubrospinal tractotomy using the lectin binding method. Following axotomy, the contralateral nucleus containing the axotomized neurons was identified using the retrograde tracer Fast blue. It was subdivided into do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01418-7
更新日期：1996-04-09 00:00:00
abstract：:Instructions are an inextricable, yet poorly understood aspect of modern human life. In this paper we propose that instruction implementation and following can be understood as fast Hebbian learning in prefrontal cortex, which trains slower pathways (e.g., cortical-basal ganglia pathways). We present a computational m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.025
更新日期：2012-02-23 00:00:00
abstract：:The newly identified neuropeptide nociceptin/orphanin FQ (NOC) was measured in different rat brain areas related to the descending anti-nociceptive pathways and compared to two opioid peptides, dynorphin B (DYN B) and Met-enkephalinArgPhe (MEAP). Two experimental models of chronic nociception, one neurogenic and one i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02432-4
更新日期：2000-02-28 00:00:00
abstract：:Noradrenergic, serotoninergic and peptidergic nerves have been demonstrated in perivascular plexuses of vasa nervorum of sympathetic, parasympathetic and somatic nerve trunks. 5-Hydroxytryptamine-, vasoactive intestinal polypeptide- and substance P-containing fibers were found by immunohistochemistry to variable exten...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90344-5
更新日期：1984-06-25 00:00:00
abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00784-1
更新日期：1997-10-24 00:00:00
abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.013
更新日期：2009-10-27 00:00:00
abstract：:Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91272-i
更新日期：1990-01-08 00:00:00
abstract：:The properties of the beta amino acid transport system were examined in cultivated rat brain astrocytes, using the specific probe, beta-alanine. The uptake of beta-alanine is thought to be glial specific. Beta-alanine was not actively transported and the intracellular accumulation was not altered by coincubation with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90856-3
更新日期：1982-05-06 00:00:00
abstract：:The intercollicular pathway of the rat was studied using autoradiographic (ARG) and horseradish peroxidase (HRP) tracing techniques. The HRP experiments demonstrated that the cells of origin of the intertectal pathway were located primarily in the rostral stratum griseum intermediale ( SGI ), stratum album intermedium...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90848-5
更新日期：1984-05-23 00:00:00
abstract：:Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that requ...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2011.09.038
更新日期：2011-11-14 00:00:00
abstract：:Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80045-9
更新日期：1992-06-26 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolite tele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90897-7
更新日期：1984-01-30 00:00:00
abstract：:Stimulation of spinal serotonin (5-HT)(2A/2C) receptors has previously been reported to lead to either a pro-nociceptive or an anti-nociceptive response. Behavioral data have indicated that the pro-nociceptive effect is related to the release of substance P (SP). The aim of this in vivo microdialysis study was to inve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03216-5
更新日期：2003-10-10 00:00:00
abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02526-5
更新日期：2003-05-30 00:00:00
abstract：:To understand the functional organization of the piriform cortex (PC), the axon collaterals of three pyramidal cells in layer IIb of the anterior PC and one pyramidal cell in layer IIb of the posterior PC were labeled and quantitatively analyzed by intracellular biocytin injection in the guinea pig. Single pyramidal c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.085
更新日期：2004-11-05 00:00:00
abstract：:Mounting evidence suggests that sleep loss negatively affects learning and memory processes through disruption of hippocampal function. In the present study, we examined whether sleep loss alters the generation, differentiation, and survival of new cells in the dentate gyrus. Rats were sleep restricted by keeping them...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.020
更新日期：2005-12-14 00:00:00
abstract：:Glial-cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN) and persephin (PSPN), known as the GDNF family ligands (GFLs), influence the development, survival and differentiation of cultured dopaminergic neurons from ventral mesencephalon (VM). Detailed knowledge about the effects of GFLs on o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.056
更新日期：2006-01-19 00:00:00
abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.023
更新日期：2019-07-01 00:00:00
abstract：:A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.046
更新日期：2019-02-15 00:00:00
abstract：:The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91983-6
更新日期：1994-11-21 00:00:00
abstract：:Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations of long-term potentiation (LTP) and paired-pulse facilitation (PPF) of hippocampal dentate gyrus in adult rats (90-115 days) following developmental lead exposure were studied in viv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00739-2
更新日期：1998-09-28 00:00:00
abstract：BACKGROUND:Sex-specific trajectories in white matter development during adolescence may help explain cognitive and behavioral divergences between males and females. Knowledge of sex differences in typically developing adolescents can provide a basis for interpreting sexual dimorphisms in abilities and actions. METHOD:...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.051
更新日期：2011-02-23 00:00:00
abstract：:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90312-0
更新日期：1989-10-23 00:00:00
abstract：:A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91171-c
更新日期：1990-03-26 00:00:00
abstract：:A cluster of trigeminal nociceptive neurons was located in the lateral sulcus on the upper bank of the frontoparietal operculum in a region bordering between cortical areas SII and 7b. These neurons were isolated in cortical cell layers IV and V-VI. All nociceptive neurons responded exclusively to noxious mechanical s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90375-2
更新日期：1989-04-10 00:00:00
abstract：:'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedbac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.069
更新日期：2010-04-30 00:00:00
abstract：:Protease-activated receptors (PARs), G-protein-coupled receptors, are widely expressed in various tissues, where they participate in physiological and pathological processes, such as hemostasis, proliferation, tissue repair, and inflammation. Recently, we found that PARs were upregulated in the rat retina following op...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.040
更新日期：2005-06-21 00:00:00
