Abstract:
:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted in rats anesthetized with chloralose, paralyzed and ventilated. rCBF was measured with [14C]iodoantipyrine as tracer and regional cerebral glucose utilization (rCGU) by [14C]2-deoxyglucose in homogenates of 11 brain regions. Neuronal perikarya in FN were excited chemically by local microinjection of the glutamate analogue kainic acid (KA) (5 nmol in 100 nl). KA elicited a transient and significant fall of arterial pressure and heart rate, the fastigial depressor response (FDR). Associated was a significant and symmetrical reduction in rCBF, to 44% of control in all regions except medulla. The response was site- and agent-specific and unrelated to the hypotension. KA also significantly and proportionally reduced, to 52% of control, rCGU in the same 10 areas of brain. In all regions the magnitudes of the reductions in rCBF and rCGU elicited by KA were linearly related. Intrinsic neurons of FN were chronically destroyed by local microinjection of the excitotoxin ibotenic acid (IBO) (10 micrograms/microliters in 0.4 microliter). Destruction of intrinsic FN neurons had no effect on resting rCBF nor on the global cerebrovascular vasodilation elicited by electrical stimulation of the FN. We conclude that: (a) excitation of intrinsic neurons of FN elicits a widespread reduction of cerebral metabolism and, secondarily, blood flow; (b) FN neurons do not exert a long-term tonic influence on brain blood flow nor metabolism; (c) the global increase in rCBF elicited by electrical stimulation of the FN is a consequence of excitation of axons projecting into or through the nucleus.
journal_name
Brain Resjournal_title
Brain researchauthors
Chida K,Iadecola C,Reis DJdoi
10.1016/0006-8993(89)90312-0subject
Has Abstractpub_date
1989-10-23 00:00:00pages
177-92issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90312-0journal_volume
500pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90081-j
更新日期:1992-03-20 00:00:00
abstract::Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91212-7
更新日期:1988-09-13 00:00:00
abstract::The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90374-5
更新日期:1988-09-20 00:00:00
abstract::Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.023
更新日期:2015-11-02 00:00:00
abstract::This study focuses on the renin-angiotensin system (RAS) in the cerebellar cortex and changes within this system after mechanically induced cerebellar injury. Using radioactive and non-radioactive in situ hybridization and immunocytochemistry angiotensinogen mRNA, angiotensinogen, angiotensin II and, for the first tim...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90520-7
更新日期:1994-12-30 00:00:00
abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91597-0
更新日期:1994-08-29 00:00:00
abstract::The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00155-j
更新日期:1995-04-24 00:00:00
abstract::In the framework of a series of investigations concerning the neural substrate of aversion, electrophysiological methods were used in order to specify, within the rat's periaqueductal gray (PAG), functional properties, viz. conduction velocity and refractory period, of PAG neurons already assessed in previous studies ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90140-x
更新日期:1986-10-29 00:00:00
abstract::Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-08-05 00:00:00
abstract::Numerous studies with PC12 cells have suggested that the mitogen-activated protein (MAP) kinase pathway might play a major role in the neuronal differentiation that is induced by nerve growth factor (NGF). Cells of the PC12D subline extend neurites within several hours in response to NGF in the presence of inhibitors ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01403-0
更新日期:1998-03-02 00:00:00
abstract::Adenine and guanine nucleotides have been shown to exert multiple roles in central and peripheral nervous systems, and the sequential breakdown of these nucleotides by enzymatic systems is an important step in the modulation of their extracellular effects. The aim of this study was to investigate whether nucleotide hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02987-6
更新日期:2002-09-20 00:00:00
abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90072-1
更新日期:1987-11-01 00:00:00
abstract::Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimulations (100 microA at 1 min intervals) delivered once per day for 14 c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.006
更新日期:2004-04-02 00:00:00
abstract::The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01241-9
更新日期:1998-01-19 00:00:00
abstract::There have been few reports concerning facilitation and depression in sympathetic ganglia9,17,40. In the present investigation, pairs of excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from bullfrog paravertebral sympathetic ganglia for an analysis of the site and mechanism responsible for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90840-4
更新日期:1976-12-10 00:00:00
abstract::The possible involvement of catecholamines in the regulation of serotonin N-acetyltransferase (NAT) activity in retina of the African clawed frog was investigated using an in vitro eye cup preparation. Dopamine (10 microM) and norepinephrine (50 microM) had no significant effect on NAT activity of eye cups incubated i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90525-1
更新日期:1986-03-26 00:00:00
abstract::The opposing actions of diphenylhydantoin (DPH) and calcium on the level of [32P]phosphate incorporation into particular rat and human brain proteins have been demonstrated in this study by employing the techniques of acrylamide gel electrophoresis and autoradiography. In the presence of calcium several brain proteins...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90930-1
更新日期:1977-09-23 00:00:00
abstract::Rats were given sham, cortical, or hippocampal lesions and sacrificed 7 or 28 days following surgery. Levels of norepinephrine, dopamine, and the major dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid (HVA), were assayed in 3 brain regions. At day 7 there was a decrease in dopamine utilizatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90996-9
更新日期:1982-12-02 00:00:00
abstract::The subthalamic nucleus receives serotonergic projections from the dorsal raphe nucleus. However, the role of serotonergic innervation in the activity of subthalamic neurons in vivo is unknown. The aim of the present work is to study the changes in the firing of subthalamic neurons in rats with 5,7-dihydroxytryptamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.052
更新日期:2007-05-29 00:00:00
abstract::The neurotoxic effects of amyloid-beta(1-42) and amyloid-beta(25-35) (A beta) on cholinergic and acetylcholinesterase-positive neurons were investigated in primary cultures derived from embryonic 18-day-old rat basal forebrain. After various time intervals, the cultures were treated with 1, 5, 10 or 20 microM A beta f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.021
更新日期:2004-02-13 00:00:00
abstract::Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90315-9
更新日期:1984-12-10 00:00:00
abstract::Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01461-3
更新日期:1998-03-09 00:00:00
abstract::This study was performed to investigate the mechanism how amantadine increases the extracellular dopamine (DA) levels in the striatum in vivo. Local application of amantadine (1 mM, 40 min) to the striatum through the dialysis membrane significantly increased the extracellular DA levels. Coadministration of nomifensin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90821-4
更新日期:1994-10-31 00:00:00
abstract::Primary afferent neurons in mammalian dorsal root ganglia (DRGs) normally function as independent sensory communication elements. However, it has recently been shown that most DRG neurons are transiently activated when axons of neighboring neurons of the same ganglion are stimulated repetitively and the cross-depolari...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02342-4
更新日期:2003-04-25 00:00:00
abstract::These experiments examined the effects of intra-amygdala injections of NMDA receptor antagonists on the acquisition and retention of inhibitory avoidance. In Expt. I, rats received bilateral intra-amygdala injections of the NMDA antagonists D,L-AP5 (1-10 micrograms), D-AP5 (0.03-1 micrograms), CPP (0.125 or 0.375 micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91188-k
更新日期:1992-07-10 00:00:00
abstract::We examined the in vitro effects of neurotransmitters, high KCl as well as sialic acid-containing compounds (GM1; SC) on transglutaminase (TG) activity in isolated superior cervical ganglia (SCG) one week after denervation or axotomy. Following denervation, TG activity in SCG decreased to 83% of the unoperated control...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90352-n
更新日期:1993-02-26 00:00:00
abstract::The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.024
更新日期:2004-09-17 00:00:00
abstract::In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/S0006-8993(96)01169-9
更新日期:1997-02-28 00:00:00
abstract::Circular RNAs (circRNAs) are a class of covalently closed non-coding RNAs, and aberrant alteration of their expression patterns is studied in numerous diseases. This study aimed to investigate whether intracerebral hemorrhage (ICH) affected circRNA expression profiles in the rat brain. Adult male Sprague-Dawley rats w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146490
更新日期:2020-01-01 00:00:00