Abstract：
:The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariectomy on female G93A mSOD1 transgenic mice, and the effect of subsequent treatment with 17beta-estradiol (E2). Ovariectomy led to a significant acceleration of disease progression of the mice, and high-dose E2 treatment significantly delayed disease progression of ovariectomized G93A mSOD1 transgenic mice. We conclude that treatment with E2 may also delay disease progression of post-menopausal women with ALS.
journal_name
Brain Resjournal_title
Brain researchauthors
Groeneveld GJ,Van Muiswinkel FL,Sturkenboom JM,Wokke JH,Bär PR,Van den Berg LHdoi
10.1016/j.brainres.2004.06.024subject
Has Abstractpub_date
2004-09-17 00:00:00pages
128-31issue
1eissn
0006-8993issn
1872-6240pii
S0006899304009655journal_volume
1021pub_type
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