Presynaptic localization of omega-conotoxin-sensitive calcium channels at the frog neuromuscular junction.

Abstract:

:By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distribution to active zones.

journal_name

Brain Res

journal_title

Brain research

authors

Torri Tarelli F,Passafaro M,Clementi F,Sher E

doi

10.1016/0006-8993(91)90981-z

subject

Has Abstract

pub_date

1991-05-03 00:00:00

pages

331-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)90981-Z

journal_volume

547

pub_type

杂志文章
  • The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures.

    abstract::We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.078

    authors: Gober MD,Laing JM,Thompson SM,Aurelian L

    更新日期:2006-11-13 00:00:00

  • Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat.

    abstract::Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90254-0

    authors: Collins F,Crutcher KA

    更新日期:1989-06-26 00:00:00

  • N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells.

    abstract::Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized hu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.04.008

    authors: Zhang X,Banerjee A,Banks WA,Ercal N

    更新日期:2009-06-12 00:00:00

  • Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin.

    abstract::This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91224-9

    authors: Broderick PA

    更新日期:1989-08-21 00:00:00

  • Brain microsomal metabolism of phencyclidine in male and female rats.

    abstract::These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00203-5

    authors: Laurenzana EM,Owens SM

    更新日期:1997-05-09 00:00:00

  • Neurogenesis in spinal cord of mouse: an autoradiographic analysis.

    abstract::An autoradiographic analysis of the time and sites of origin, and the migration and settling patterns of neurons was made in the spinal cord of the mouse. The neurons originated on days 10--14 of gestation with temporal gradients along the ventrodorsal and rostrocaudal axes. The motor neurons originated on days 10 and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90105-1

    authors: Nornes HO,Carry M

    更新日期:1978-12-22 00:00:00

  • Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.

    abstract::The homozygous Brattleboro rat (di/di), displaying a hypothalamic form of diabetes insipidus, synthesizes a vasopressin (VP) precursor with an abnormal C-terminus. The phenotypic expression of coexisting peptides in mutant magnocellular VP cells shows a differential pattern. 7B2 is one of the peptides which is not det...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91218-4

    authors: Gabreëls BA,Sonnemans MA,Seidah NG,Chrétien M,van Leeuwen FW

    更新日期:1992-07-10 00:00:00

  • Exercise affects glutamate receptors in postsynaptic densities from cortical mice brain.

    abstract::Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.09.038

    authors: Dietrich MO,Mantese CE,Porciuncula LO,Ghisleni G,Vinade L,Souza DO,Portela LV

    更新日期:2005-12-14 00:00:00

  • Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics.

    abstract::Altered noradrenergic function is associated with alcoholism. Reduced brain norepinephrine (NE) concentrations and beta-adrenergic receptor supersensitivity following chronic alcohol consumption suggest a reduced level of noradrenergic neurotransmission. To further elucidate the reason for changes in noradrenergic fun...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90199-6

    authors: Arango V,Underwood MD,Mann JJ

    更新日期:1994-07-04 00:00:00

  • The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat.

    abstract::Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90064-i

    authors: Gilbert ME,Mack CM

    更新日期:1990-06-11 00:00:00

  • Dopamine decreases the calcium-activated afterhyperpolarization in hippocampal CA1 pyramidal cells.

    abstract::The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90773-0

    authors: Malenka RC,Nicoll RA

    更新日期:1986-08-06 00:00:00

  • Dopamine transporter: deglycosylation with exo- and endoglycosidases.

    abstract::The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91627-d

    authors: Lew R,Grigoriadis D,Wilson A,Boja JW,Simantov R,Kuhar MJ

    更新日期:1991-01-25 00:00:00

  • Effect of 4-aminopyridine on transmitter release in synaptosomes.

    abstract::The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90423-1

    authors: Tapia R,Sitges M

    更新日期:1982-11-04 00:00:00

  • Facilitation of amphetamine-induced rotation by muscarinic antagonists is correlated with M2 receptor affinity.

    abstract::This study examined the relationship between the affinity of cholinergic drugs for muscarinic receptor subtypes and their potency in potentiating or inhibiting amphetamine-induced rotation. The ascending nigrostriatal dopaminergic pathway was unilaterally lesioned in male Wistar rats using 6-hydroxydopamine. In these ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(87)80021-5

    authors: Hagan JJ,Tonnaer JA,Rijk H,Broekkamp CL,van Delft AM

    更新日期:1987-04-28 00:00:00

  • Localization of the ras-like rab3A protein in the adult rat brain.

    abstract::Rab3A is a small GTP-binding synaptic vesicle protein, shown to dissociate from synaptic vesicle membranes upon depolarization-induced exocytosis. Using an antiserum raised against rab3A, we found that the antigen was localized to the neuropil of specific brain regions, but was not present in major fiber tracts or mos...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91087-u

    authors: Moya KL,Tavitian B,Zahraoui A,Tavitian A

    更新日期:1992-09-11 00:00:00

  • Dopamine-containing amacrine cells of rhesus monkey retina parallel rods in spatial distribution.

    abstract::Dopamine-containing amacrine cells of rhesus monkey were found everywhere outside of the foveola in whole, flat retinas by the formaldehyde-glutaraldehyde fluorescent method. There were about 7500 such cells in a single retina and their density, determined by cell counts and measured by a nearest neighbor method, was ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91174-0

    authors: Mariani AP,Kolb H,Nelson R

    更新日期:1984-11-19 00:00:00

  • Localization of cholecystokinin-octapeptide-like-immunoreactivity in neurons cultured from rat cerebral cortex.

    abstract::Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91456-2

    authors: Delfs JR,Zhu CH,Dichter MA

    更新日期:1984-02-13 00:00:00

  • Substance P containing polymer implants protect against striatal excitotoxicity.

    abstract::The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of ea...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90974-r

    authors: Sanberg PR,Emerich DF,Aebischer P,Amisetti SM,Ouellette W,Koutouzis TK,Cahill DW,Norman AB

    更新日期:1993-11-19 00:00:00

  • Brain stem influences on the parasympathetic supply to the urinary bladder of the cat.

    abstract::(1)The brain stem of anaesthetized cats has been mapped between Horsley-Clark planes APO and P8.5 with electrical stimuli of low intensity in order to determine the areas which can produce excitatory of inhibitory influences on the spontaneously contracting, sympathetically denervated, urinary bladder. (2) Two inhibit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90865-4

    authors: McMahon SB,Spillane K

    更新日期:1982-02-25 00:00:00

  • Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease.

    abstract::Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02417-8

    authors: Newman SJ,Bond B,Crook B,Darker J,Edge C,Maycox PR

    更新日期:2000-02-28 00:00:00

  • Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.

    abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146760

    authors: Jung S,Ballheimer YE,Brackmann F,Zoglauer D,Geppert CI,Hartmann A,Trollmann R

    更新日期:2020-05-15 00:00:00

  • Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling.

    abstract::Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.09.009

    authors: Xie R,Li X,Ling Y,Shen C,Wu X,Xu W,Gao X

    更新日期:2012-10-30 00:00:00

  • Effects of stimulating the reticular formation during fictive locomotion in lampreys.

    abstract::The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00151-0

    authors: Guertin P,Dubuc R

    更新日期:1997-04-11 00:00:00

  • Neuropeptide Y attenuates NMDA-induced phase shifts in the SCN of NPY Y1 receptor knockout mice in vitro.

    abstract::Neuropeptide Y (NPY) blocks the effect of light on the mammalian circadian clock during the subjective night. The present study explores the role of the NPY Y1 receptor in this interaction. The effect of NPY when co-applied with NMDA, a glutamate agonist that can mimic the effect of light, was examined in NPY Y1-/- mi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.07.037

    authors: Soscia SJ,Harrington ME

    更新日期:2004-10-08 00:00:00

  • Brain glutamate inhibition and amnesia: evidence provided by proline analog action.

    abstract::The action of proline and its analog as glutamate antagonists was investigated in CNS tissue of the neonatal chick. Avian brain slices were incubated in low concentrations of L-proline, D-proline, DL-3,4-dehydro-proline, L-prolyl-L-proline, or in avian physiological salt solution before depolarization was induced by a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90056-1

    authors: Pico RM,Keller E,Cherkin A,Davis JL

    更新日期:1983-08-01 00:00:00

  • Response dynamics of entorhinal cortex in awake, anesthetized, and bulbotomized rats.

    abstract::The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02687-7

    authors: Ahrens KF,Freeman WJ

    更新日期:2001-08-24 00:00:00

  • Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects.

    abstract::Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Fernandes C,File SE,Berry D

    更新日期:1996-09-23 00:00:00

  • Pathogenic role of autoantibodies against inhibitory synapses.

    abstract::Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2018.09.009

    authors: Prüss H,Kirmse K

    更新日期:2018-12-15 00:00:00

  • Neuronal death in the lateral geniculate nucleus of young ferrets following a cortical lesion: time-course, age dependence and involvement of caspases.

    abstract::In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.05.063

    authors: Gautschi M,Clarke PG

    更新日期:2007-09-05 00:00:00

  • Evidence that 4S RNA is axonally transported in normal and regenerating rat sciatic nerves.

    abstract::Studies in regenerating goldfish optic nerves indicate that RNA may be axonally transported during optic nerve regeneration14,18,19. The present study was performed to determine if the axonal migration of RNA could be demonstrated during regeneration of the rat sciatic nerve. Rats, which had only the left sciatic nerv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90652-8

    authors: Lindquist TD,Inogoglia NA

    更新日期:1979-04-20 00:00:00