Abstract：
:This study examined the relationship between the affinity of cholinergic drugs for muscarinic receptor subtypes and their potency in potentiating or inhibiting amphetamine-induced rotation. The ascending nigrostriatal dopaminergic pathway was unilaterally lesioned in male Wistar rats using 6-hydroxydopamine. In these rats, ipsiversive rotation induced by amphetamine sulphate (1 mg/kg, s.c.) was dose-dependently inhibited by the cholinergic agonists oxotremorine, RS86 and pilocarpine and by the acetylcholinesterase inhibitor physostigmine. In contrast the cholinergic antagonists scopolamine, secoverine and dicyclomine facilitated amphetamine-induced rotation. Agonist and antagonist potencies were then compared with M1 and M2 binding site affinities estimated by displacing [3H]pirenzepine from forebrain and [3H]QNB from brainstem homogenates. The data suggest a relationship between antagonist potency and M2 binding site affinity.
journal_name
Brain Resjournal_title
Brain researchauthors
Hagan JJ,Tonnaer JA,Rijk H,Broekkamp CL,van Delft AMdoi
10.1016/s0006-8993(87)80021-5subject
Has Abstractpub_date
1987-04-28 00:00:00pages
69-73issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(87)80021-5journal_volume
410pub_type
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