Abstract：
:The thalamic paraventricular nucleus (PVT) receives afferents from numerous brain areas, including the hypothalamic suprachiasmatic nucleus (SCN), considered to be the major circadian pacemaker. The PVT also sends projections to the SCN, limbic system centers and some nuclei involved in the control of the Sleep-Wake cycle. In this study, we report the identification of a hitherto not reported direct retinal projection to the PVT of the rock cavy, a typical rodent species of the northeast region of Brazil. After unilateral intravitreal injections of cholera toxin subunit B (CTb), anterogradely transported CTb-immunoreactive fibers and presumptive terminals were seen in the PVT. Some possible functional correlates of the present data are briefly discussed, including the role of the PVT in the modulation of the circadian rhythms by considering the reciprocal connections between the PVT and the SCN. The present work is the first to show a direct retinal projection to the PVT of a rodent and may contribute to elucidate the anatomical substrate of the functionally demonstrated involvement of this midline thalamic nucleus in the modulation of the circadian timing system.
journal_name
Brain Resjournal_title
Brain researchauthors
Nascimento ES Jr,Duarte RB,Silva SF,Engelberth RC,Toledo CA,Cavalcante JS,Costa MSdoi
10.1016/j.brainres.2008.09.017subject
Has Abstractpub_date
2008-11-19 00:00:00pages
56-61eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02251-8journal_volume
1241pub_type
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