Abstract：
:Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.
journal_name
Brain Resjournal_title
Brain researchauthors
Gulya K,Grant KA,Valverius P,Hoffman PL,Tabakoff Bsubject
Has Abstractpub_date
1991-04-26 00:00:00pages
129-34issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90583-Hjournal_volume
547pub_type
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