Abstract:
:The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activational effects of testosterone in adulthood, and any interactions on regional volume and neuronal number of the medial amygdala. Male Syrian hamsters either did or did not experience endogenous testosterone during pubertal brain development, and then received either testosterone-filled or blank capsules during adulthood 2 weeks before tissue collection. The results show that pubertal testosterone has long-term organizational effects on volume of specific subregions of the medial amygdala such that the presence of pubertal testosterone resulted in 1) decreased volume of the anterior ventral amygdala and, to a lesser extent, the anterior dorsal medial amygdala; and 2) increased volume of the posterior dorsal medial amygdala. Both effects were independent of the presence of testosterone during adulthood. Pubertal testosterone also decreased neuronal number in the anterior dorsal medial amygdala, suggesting a possible mechanism by which pubertal testosterone decreases volume in this subregion. In addition, there was a significant interaction between pubertal and adult testosterone, such that testosterone in adulthood increased the number of neurons in the posterior ventral medial amygdala only in males that did not experience endogenous pubertal testosterone. In conclusion, pubertal testosterone organizes the medial amygdala in a subregion-specific manner, which may contribute to the maturation of adult-typical social behavior.
journal_name
Brain Resjournal_title
Brain researchauthors
De Lorme KC,Schulz KM,Salas-Ramirez KY,Sisk CLdoi
10.1016/j.brainres.2012.04.035subject
Has Abstractpub_date
2012-06-15 00:00:00pages
33-40eissn
0006-8993issn
1872-6240pii
S0006-8993(12)00751-2journal_volume
1460pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Event-related potentials (ERP) were measured when pleasant, neutral or unpleasant pictures were presented in the context of similarly valenced stimuli, and compared to ERPs elicited when the same pictures were viewed in an intermixed context. An early ERP component (150-300 ms) measured over occipital and fronto-centr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.072
更新日期:2008-01-16 00:00:00
abstract::A morphosyntactic agreement violation during reading elicits a well-documented biphasic ERP pattern (LAN+P600). The cognitive variables that affect both the amplitude of the two components and the topography of the anterior negativity are still debated. We studied the ERP correlates of the violation of a specific agre...
journal_title:Brain research
pub_type: 临床试验,杂志文章
doi:10.1016/j.brainres.2008.06.064
更新日期:2008-09-04 00:00:00
abstract::To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.134
更新日期:2007-05-04 00:00:00
abstract::Serotonin (5HT) is thought to reset the biological clock in the suprachiasmatic nuclei (SCN) in vitro through a postsynaptic 5HT-1a receptor. Thus we examined 5HT receptor gene expression in the SCN by in situ hybridization. On film autoradiograms, 5HT-1c receptor mRNA showed intense SCN hybridization, while 5HT-1b re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90789-p
更新日期:1993-04-09 00:00:00
abstract::Seventy-nine single units were recorded with glass micropipettes applied onto taste pores of the anterior portion of the tongue in anesthetized hamsters. The receptive field of each recorded unit was located by iontophoretic stimulation applying either anodal or cathodal current (1-20 microA) to a non-stimulating solu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90643-P
更新日期:1990-04-02 00:00:00
abstract::The intra-axonal transport of horseradish peroxidase (HRP) has been used to trace the nodose ganglion and brain stem projections of a physiologically distinct nerve - the aortic depressor nerve - following electrophysiological identification. Tetramethyl benzidine (TMB) has been used as the substrate for demonstrating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90553-3
更新日期:1980-04-21 00:00:00
abstract::The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is synthesized by discrete populations of hypothalamic neurons which project in different brain regions including the cerebral cortex, hippocampus and amygdala nuclei. The purpose of the present study was to identify the alpha-MSH-immunoreactive species...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90471-m
更新日期:1990-04-16 00:00:00
abstract::Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron numbe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02365-5
更新日期:2003-05-09 00:00:00
abstract::This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91192-2
更新日期:1984-11-19 00:00:00
abstract::Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.014
更新日期:2013-08-14 00:00:00
abstract::The solubilized rat central nervous system (hypothalamic) nicotinic cholinergic receptor and the Torpedo nicotinic cholinergic receptors are immunologically similar and show greater than 60% immunologic cross-reactivity using a double-antibody technique. Antibodies to the Electrophorus and Torpedo receptors also decre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90700-5
更新日期:1979-12-14 00:00:00
abstract::A technique is described for the autoradiographic localization of D-glucose inhibitable cytochalasin B binding in fresh frozen sections of rat brain. The technique has been used to study the regional distribution of glucose transporter proteins. Binding sites within the cerebellum and hippocampus were more concentrate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91552-1
更新日期:1988-05-31 00:00:00
abstract::Neuronal transmission through hippocampal subfields exhibits a high degree of modulation and appears dependent on the behavioral state and hippocampal EEG. Sensory inputs, which profoundly modify the hippocampal EEG, may be involved in modulating hippocampal excitability. Field responses of the CA1 region, evoked by i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90259-4
更新日期:1988-10-04 00:00:00
abstract::These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00203-5
更新日期:1997-05-09 00:00:00
abstract::In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90213-2
更新日期:1988-12-13 00:00:00
abstract::Malignant glioma cells maintain an elevated intracellular pH (pH(i)) within hypoxic-ischemic tumor microenvironments through persistent activation of sodium-proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astrocytes (Hegde et al....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.059
更新日期:2010-12-02 00:00:00
abstract::Zif268 transcription factor is expressed throughout Cebus apella visual cortex at high basal levels. Monocular eyelid suture alters the levels of Zif268 on neurons connected to the deprived eye, revealing ocular dominance columns in the striate cortex of Cebus as previously demonstrated in Old World monkeys (Chaudhuri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00590-2
更新日期:1996-09-02 00:00:00
abstract::A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90207-4
更新日期:1982-03-04 00:00:00
abstract::The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90977-4
更新日期:1991-05-03 00:00:00
abstract::The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.084
更新日期:2010-04-06 00:00:00
abstract::The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00930-x
更新日期:1997-11-14 00:00:00
abstract::The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00990-0
更新日期:1996-10-28 00:00:00
abstract::The conditioned place preference paradigm was used to study the reinforcing properties of D-amphetamine. Rats were injected (i.p.) with D-amphetamine sulphate (0.5, 1.0 or 5.0 mg/kg) and 10 min later confined for 30 min to one side of a shuttle box in which each of the two compartments had distinctive features. On alt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90685-0
更新日期:1982-12-16 00:00:00
abstract::The pharmacology of excitatory cholinergic responses in CA1 pyramidal cells was examined in detail using intracellular recording from the hippocampal slice preparation. Acetylcholine (ACh), carbachol, muscarine and pilocarpine depolarized the membrane potential with an associated increase in input resistance. In addit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90434-7
更新日期:1984-07-09 00:00:00
abstract::In a previous study we reported significant elevations of TRH in neocortex, hippocampus and combined amygdala/pyriform cortex in rats 48 h after the last of a series of stage 5 kindled seizures. In the present study, to determine whether the increases in TRH were proportional to the intensity of the convulsions, and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91330-j
更新日期:1990-08-13 00:00:00
abstract::The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90090-i
更新日期:1991-06-28 00:00:00
abstract::The origin of the afferents of the thalamic anterior paraventricular and parataenial nuclei (PVA-PT) in the rat was studied with fluorescent retrograde tracing method. After iontophoretic application of Fluoro-Gold into PVA-PT, many labeled cells were found in the medial frontal cortex, ventral subiculum, claustrum, s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91570-7
更新日期:1990-07-02 00:00:00
abstract::The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.044
更新日期:2010-03-31 00:00:00
abstract::We found that local perfusion of COA-Cl (0.1, 0.4, or 1.0 mM) into the dorsal striatum of living mice produced a significant and dose-dependent increase in extracellular DA levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Consistent with in vivo findings, 0.1 and 0.2 mM ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.026
更新日期:2019-03-01 00:00:00
abstract::Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90494-5
更新日期:1988-08-16 00:00:00