Abstract：
:The solubilized rat central nervous system (hypothalamic) nicotinic cholinergic receptor and the Torpedo nicotinic cholinergic receptors are immunologically similar and show greater than 60% immunologic cross-reactivity using a double-antibody technique. Antibodies to the Electrophorus and Torpedo receptors also decrease the rate of alpha-bungarotoxin binding to these membraneous receptors. It is concluded that the Torpedo and hypothalamic nicotinic receptors are immunologically similar and that receptor binding sites for alpha-bungarotoxin and antibodies are physically close. These studies indicate that alpha-bungarotoxin can be used to study the nicotinic cholinergic receptor of the rat hypothalamus.
journal_name
Brain Resjournal_title
Brain researchauthors
Block GA,Billiar RBdoi
10.1016/0006-8993(79)90700-5subject
Has Abstractpub_date
1979-12-14 00:00:00pages
381-7issue
2-3eissn
0006-8993issn
1872-6240pii
0006-8993(79)90700-5journal_volume
178pub_type
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