Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan.

Abstract:

:The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT receptor blocker, cinanserin. These results are in keeping with those of our recent single unit work in dorsal horn convergent neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Kraus E,Besson JM,Le Bars D

doi

10.1016/0006-8993(82)90384-5

subject

Has Abstract

pub_date

1982-01-14 00:00:00

pages

461-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(82)90384-5

journal_volume

231

pub_type

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