Opiate-like excitatory effects of steroid sulfates and calcium-complexing agents given cerebroventricularly.

Abstract:

:Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodium sulfate or phosphate, but not chloride, nitrate or acetate. Non-steroid sulfates, steroid glucuronides and steroid phosphates were inactive. Naloxone, previously found to antagonize the excitatory effects of androsterone sulfate, failed to antagonize those of cortisol sulfate, sodium sulfate or EGTA. These findings suggest a role for extracellular calcium ions and for sulfate derived from circulating steroids in central responses to opiates.

journal_name

Brain Res

journal_title

Brain research

authors

LaBella FS,Havlicek V,Pinsky C

doi

10.1016/0006-8993(79)90426-8

subject

Has Abstract

pub_date

1979-01-12 00:00:00

pages

295-305

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(79)90426-8

journal_volume

160

pub_type

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