Abstract:
:Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodium sulfate or phosphate, but not chloride, nitrate or acetate. Non-steroid sulfates, steroid glucuronides and steroid phosphates were inactive. Naloxone, previously found to antagonize the excitatory effects of androsterone sulfate, failed to antagonize those of cortisol sulfate, sodium sulfate or EGTA. These findings suggest a role for extracellular calcium ions and for sulfate derived from circulating steroids in central responses to opiates.
journal_name
Brain Resjournal_title
Brain researchauthors
LaBella FS,Havlicek V,Pinsky Cdoi
10.1016/0006-8993(79)90426-8subject
Has Abstractpub_date
1979-01-12 00:00:00pages
295-305issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(79)90426-8journal_volume
160pub_type
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