Abstract：
:The electrical property of delayed K+ currents (IKD) was studied in pyramidal neurones freshly isolated from the rat hippocampal CA1 region. The IKD was separated pharmacologically from other membrane currents. Activation and inactivation processes of the IKD were highly voltage-dependent in the potential range between -30 and +20 mV. The steady-state inactivation of IKD was observed at -100 mV or more positive potentials. The potential for half steady-state inactivation was -65 mV. The IKD was fully inactivated around -20 mV. Reactivation of IKD consisted of two exponential components. After pharmacological suppression of IKD, the small amount of residual voltage-dependent outward current (one-fifteenth to one-twentieth of IKD amplitude) was observed. The current kinetics was similar to that of IKD and greatly reduced by substitution of internal K+ with N-methyl-D-glucamine+. It was concluded that the properties of IKD was basically similar to those of IKD in other excitable tissues and that the residual current might be non-specific outward current.
journal_name
Brain Resjournal_title
Brain researchauthors
Oyama Y,Harata N,Akaike Ndoi
10.1016/0006-8993(91)91425-zsubject
Has Abstractpub_date
1991-12-24 00:00:00pages
350-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91425-Zjournal_volume
568pub_type
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