Abstract：
:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body weight) AG treatment. High dose (100 mg kg-1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Ino-ue M,Ohgiya N,Yamamoto Mdoi
10.1016/s0006-8993(98)00512-5subject
Has Abstractpub_date
1998-08-03 00:00:00pages
319-22issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00512-5journal_volume
800pub_type
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