Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.

abstract：:Toluene diisocyanate (TDI) induces respiratory allergy in mammals. Using immunohistochemistry and in situ hybridization histochemistry, the present study examined effects of nasal mucosa sensitization by TDI on the immunoreactivity for substance P (SP) and calcitonin gene-related peptide (CGRP) and on the expression o...

journal_title：Brain research

authors： Kalubi B,Takeda N,Irifune M,Ogino S,Abe Y,Hong SL,Yamano M,Matsunaga T,Tohyama M

更新日期：1992-04-03 00:00:00

abstract：:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...

journal_title：Brain research

authors： Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A

更新日期：2010-06-25 00:00:00

abstract：:The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...

journal_title：Brain research

authors： Uchiyama H,Seki A,Kageyama H,Saito DN,Koeda T,Ohno K,Sadato N

更新日期：2006-12-08 00:00:00

abstract：:Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...

journal_title：Brain research

authors： Schwippert WW,Ewert JP

更新日期：1995-01-09 00:00:00

abstract：:Electroconvulsive stimulation (ECS), the experimental analogue of electroconvulsive therapy (ECT), has been shown to produce both functional and structural effects in the hippocampal formation in infrahuman species. These changes may relate to the antidepressant and cognitive effects of ECT observed in patients treate...

journal_title：Brain research

authors： Lamont SR,Stanwell BJ,Hill R,Reid IC,Stewart CA

更新日期：2005-08-16 00:00:00

abstract：:The effects of repeated, once daily exposure to either restraint or tail pinch stress on extracellular levels of dopamine in nucleus accumbens and striatum were electrochemically monitored in conscious rats using high-speed chronoamperometry. Acutely, both tail pinch and restraint increased extracellular dopamine leve...

journal_title：Brain research

authors： Doherty MD,Gratton A

更新日期：1992-07-24 00:00:00

abstract：:Estrogen effects on tyrosine hydroxylase (TH), monoamine oxidase types A and B (MAO), and dopamine (DA) in microdissected regions of the hypothalamus, preoptic area and substantia nigra (SNR) of the female rat brain were investigated. Ovariectomized (OVX) young adult female rats were implanted with single silastic cap...

journal_title：Brain research

authors： Jones EE,Naftolin F

更新日期：1990-02-26 00:00:00

abstract：:Cervical spinal cord hemisection leads to a disruption of bulbospinal innervation of phrenic motoneurons resulting in paralysis of the ipsilateral hemidiaphragm. We have previously demonstrated separate therapeutic roles for theophylline, and more recently serotonin (5-HT) as modulators to phrenic nerve motor recovery...

journal_title：Brain research

authors： Basura GJ,Nantwi KD,Goshgarian HG

更新日期：2002-11-22 00:00:00

abstract：:Invasion of scrapie agent into the central nervous system (CNS) was studied in rats following intracerebral and peripheral inoculation, the latter by injection into intact or transected sciatic nerve. Comparison of sleep-wakefulness alterations, neuropathological features, and time lag of electroencephalographic and c...

journal_title：Brain research

authors： Bassant MH,Baron H,Gumpel M,Cathala F,Court L

更新日期：1986-09-24 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...

journal_title：Brain research

authors： Grinevich V,Fournier A,Pelletier G

更新日期：1997-10-31 00:00:00

abstract：:The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian r...

journal_title：Brain research

authors： Kimura F,Mitsugi N,Arita J,Akema T,Yoshida K

更新日期：1987-05-05 00:00:00

abstract：:Locomotor stepping elicited by lateral hypothalamic stimulation in the anesthetized rat is blocked by lesions in the anterior ventromedial midbrain. This study determined in acute experiments whether the dorsal midbrain regions implicated in locomotion were also part of the necessary pathway. Rats were anesthetized wi...

journal_title：Brain research

authors： Sinnamon HM,Stopford CK

更新日期：1987-01-27 00:00:00

abstract：:Traumatic brain injury (TBI) in humans typically produces neurological suppression and a longer lasting impairment of memory clinically defined as post-traumatic amnesia. An animal model that reliably reproduces the physiological changes associated with TBI was used to assess the memory deficits following brain injury...

journal_title：Brain research

authors： Gorman LK,Shook BL,Becker DP

更新日期：1993-06-18 00:00:00

abstract：:Recent reports of the transsynaptic transfer of wheat germ agglutinin (WGA) in several systems are consistent with the hypothesis that WGA binds to endogenous glycoproteins(s) which undergo transsynaptic transfer. Such molecules might be involved in trophic interactions between neurons. Since these hypothetical glycop...

journal_title：Brain research

authors： Rhodes CH,Gonatas NK

更新日期：1986-12-03 00:00:00

abstract：:The behavioral and EEG effects of rat and ovine corticotropin releasing factor (r- and o-CRF) were compared. Both peptides were injected intracerebroventricularly into rats through chronically implanted cannulae. At the doses of 0.1 and 1 microgram both peptides activated the EEG and stimulated motor activity. At the ...

journal_title：Brain research

authors： Marrosu F,Mereu G,Fratta W,Carcangiu P,Camarri F,Gessa GL

更新日期：1987-04-07 00:00:00

abstract：:Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders. Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred populations which could lead to genotypic and phenotypic heterogeneity between rats from different vendors. Additionally, vendor specific rear...

journal_title：Brain research

authors： Theilmann W,Kleimann A,Rhein M,Bleich S,Frieling H,Löscher W,Brandt C

更新日期：2016-07-01 00:00:00

abstract：:To investigate the role of Ca2+ in astrocyte volume regulation, we determined Ca2+ fluxes following hypoosmotic stress and how these fluxes were modified by cyclic AMP. In isoosmotic conditions treatment with dibutyryl cyclic AMP (dBcAMP) caused almost a twofold increase in 45Ca2+ uptake. Efflux studies of 45Ca2+ in d...

journal_title：Brain research

authors： Bender AS,Mantelle LL,Norenberg MD

更新日期：1994-05-09 00:00:00

abstract：:The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...

journal_title：Brain research

authors： Reyher CK

更新日期：1988-08-02 00:00:00

abstract：:The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was sensitive to lesions induced by focal cerebral ischemia. Sprague-Dawley rats were pre-screened for startle reflex responses 3-6 days prior to surgery and there were ...

journal_title：Brain research

authors： Maynard KI,Sukoff SJ,Ji Z,Wettstein JG,Black MD

更新日期：2005-01-25 00:00:00

abstract：:Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats wer...

journal_title：Brain research

authors： Ho Y,Liu T,Tai M,Wen Z,Chow RS,Tsai Y,Wong C

更新日期：2001-05-11 00:00:00

abstract：:Ginseng is one of most extensively used traditional oriental medicines worldwide with beneficial efficacy on cognitive function disorders. Pharmacological researches on its active ingredient--ginsenoside Rg1 revealed that it can improve learning and memory potentially via modulating neurotransmission in the central ne...

journal_title：Brain research

authors： Liu ZJ,Zhao M,Zhang Y,Xue JF,Chen NH

更新日期：2010-05-28 00:00:00

abstract：:Spontaneous alternation which is disrupted by lesion of septal dopaminergic (DA) afferents was chosen as a behavioral marker for the study of functional interactions between DA and noradrenergic (NA) innervation of the lateral septum. Three groups of rats were studied: a solvent group which received only vehicle injec...

journal_title：Brain research

authors： Taghzouti K,Le Moal M,Simon H

更新日期：1991-06-21 00:00:00

abstract：:It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment aff...

journal_title：Brain research

authors： Chikama K,Yamada H,Tsukamoto T,Kajitani K,Nakabeppu Y,Uchimura N

更新日期：2017-12-01 00:00:00

abstract：:Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...

journal_title：Brain research

authors： Takano M,Horie M,Yayama K,Okamoto H

更新日期：2003-07-18 00:00:00

abstract：:Sokoloff's [14C]2-deoxyglucose method has been applied to investigate circadian variations in local cerebral glucose utilization (LCGU). Freely moving rats were tested during two phases of the circadian light/dark cycle. In the rats tested during darkness, elevations in LCGU, when compared with animals tested during t...

journal_title：Brain research

authors： Room P,Tielemans AJ

更新日期：1989-12-29 00:00:00

abstract：:Event-related potentials (ERPs) were recorded using a large electrode array while subjects engaged in tasks designed to dissociate control from storage/maintenance processes in verbal working memory (WM). Increased ERP negativity (450-900 ms post-stimulus onset) over left frontal regions emerged only when required dyn...

journal_title：Brain research

authors： Kiss I,Watter S,Heisz JJ,Shedden JM

更新日期：2007-10-03 00:00:00

abstract：:Behavioral stress is likely to contribute to the development of hypertension in susceptible individuals. We reported that hemodynamic response patterns to acute startle vary and that those patterns predict the predisposition of rats to sustained stress-induced elevations in arterial pressure. Since considerable eviden...

journal_title：Brain research

authors： Tan Y,Gan Q,Knuepfer MM

更新日期：2003-04-04 00:00:00

abstract：:In continuation of earlier computer simulation studies 15 of the feedback inhibition exercised by the Golgi cells of the cerebellum, an attempt is made at modeling the behavior of Purkinje and basket cells under somewhat more complex functional circumstances. The simulation study is based on a realistic network model ...

journal_title：Brain research

authors： Pellionisz A,Szentàgothai J

更新日期：1974-03-15 00:00:00

abstract：:The effects of 4 anaesthetics, halothane, alpha-chloralose, chloral hydrate and pentobarbitone, on rat striatal extracellular dihydroxyphenylacetic acid (DOPAC) levels were determined using in vivo voltammetry. Stable baseline levels of DOPAC were maintained under halothane/N2O and alpha-chloralose while the extracell...

journal_title：Brain research

authors： Ford AP,Marsden CA

更新日期：1986-07-30 00:00:00

abstract：:To determine whether postmitotic neurons can be immortalized by oncogenic transduction, we used two approaches involving conditional expression of a temperature-sensitive SV40 large T antigen (Tts). Initially, Tts was introduced into E17 rat embryonal hippocampal cells that were then cultured at the non-permissive tem...

journal_title：Brain research

authors： Eves EM,Kwon J,Downen M,Tucker MS,Wainer BH,Rosner MR

更新日期：1994-09-12 00:00:00