Stimulation of calcium uptake in cultured astrocytes by hypoosmotic stress--effect of cyclic AMP.

abstract：:Thresholds of induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brain were investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. In sham control brain, HSP70 mRNA was little present, while HSC70 mRN...

journal_title：Brain research

authors： Kawagoe J,Abe K,Kogure K

更新日期：1992-12-25 00:00:00

abstract：:The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...

journal_title：Brain research

authors： Piao LH,Fujita T,Yu T,Kumamoto E

更新日期：2017-02-15 00:00:00

abstract：:Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...

journal_title：Brain research

authors： Kamisaki Y,Maeda K,Ishimura M,Omura H,Itoh T

更新日期：1993-11-12 00:00:00

abstract：:Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the ...

journal_title：Brain research

authors： Bellin SI,Bhatnagar RK,Johnson AK

更新日期：1987-02-10 00:00:00

abstract：:It has been shown that glucagon like peptide-1 (GLP-1) acts on the central nervous system (CNS), in addition to its peripheral actions. Central administration of glucagon like peptide-1 (GLP-1) delays liquid gastric emptying via non-adrenergic, non-cholinergic neurons in rats. However, it remains unclear how central G...

journal_title：Brain research

authors： Nakade Y,Tsukamoto K,Pappas TN,Takahashi T

更新日期：2006-09-21 00:00:00

abstract：:We assessed the effects of simulated weightlessness, hindlimb unloading (HU) by 7 days of tail suspension, on noxious mechanically and heat evoked spinal withdrawal reflexes and spinal Fos expression during muscle nociception elicited by intramuscular (i.m.) injection of hypertonic (HT; 5.8%) saline into gastrocnemius...

journal_title：Brain research

authors： Lei J,Pertovaara A,You HJ

更新日期：2015-01-12 00:00:00

abstract：:Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...

journal_title：Brain research

authors： Vandermaelen CP,Aghajanian GK

更新日期：1982-05-06 00:00:00

abstract：:Male rats were dehydrated for 22 h and then given 4 h intracerebroventricular (i.c.v.) infusions which commenced 2 h prior to the beginning of a 2-h fluid access period. I.c.v. infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access per...

journal_title：Brain research

authors： Osborne PG,Denton DA,Weisinger RS

更新日期：1987-05-26 00:00:00

abstract：:Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...

journal_title：Brain research

authors： Gramsbergen JB,Schmidt W,Turski WA,Schwarcz R

更新日期：1992-08-14 00:00:00

abstract：:Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...

journal_title：Brain research

authors： Tanaka K,Graham SH,Simon RP

更新日期：1996-10-21 00:00:00

abstract：:Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the mechanisms underlying this symptom, it was studied and compared in rat models of systemic and local hyperglycemia. Systemic hyperglycemia was induced by a single injection of streptozotocin (STZ, 50 mg/kg). Local hyperglycemia either i...

journal_title：Brain research

authors： Dobretsov M,Hastings SL,Romanovsky D,Stimers JR,Zhang JM

更新日期：2003-01-17 00:00:00

abstract：:The organization of neuronal cell bodies in the caudal preoptic area (POA) and rostral anterior hypothalamic area (AH) was studied in Nissl-stained brain sections from adult male and female ferrets. Computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes ...

journal_title：Brain research

authors： Tobet SA,Zahniser DJ,Baum MJ

更新日期：1986-02-05 00:00:00

abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...

journal_title：Brain research

authors： Friedrich VL Jr,Mugnaini E

更新日期：1983-09-12 00:00:00

abstract：:The expression of adenylyl cyclase (AC) isoforms in the adult rat vestibular periphery was investigated using reverse transcription polymerase chain reaction (RT-PCR). AC II, IV and V mRNAs were expressed in both Scarpa's ganglion and vestibular end organs. In addition, in the vestibular end organs, an AC mRNA not pre...

journal_title：Brain research

authors： Wackym PA,Troyanovskaya M,Popper P

更新日期：2000-03-24 00:00:00

abstract：:Perfusion of hippocampal slices with normoxic medium containing no added sodium resulted in a rapid loss of the CA1 population spike, with only 35 +/- 10% (S.E.M.) (P < 0.001) recovery after a 15 min exposure. This injury was prevented by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (93 +/- 4% rec...

journal_title：Brain research

authors： Parsons JE,Wallis RA,Panizzon KL,Wasterlain CG

更新日期：1992-11-06 00:00:00

abstract：:Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...

journal_title：Brain research

authors： Gruner JA,Yee AK,Blight AR

更新日期：1996-08-05 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...

journal_title：Brain research

authors： Tataroğlu O,Aksoy A,Yilmaz A,Canbeyli R

更新日期：2004-03-19 00:00:00

abstract：:We compared changes in levels of substance P-like immunoreactivity (SPLI) in L4-6 dorsal root ganglia (DRG), L4-6 dorsal roots, sciatic nerve, tibial nerve and hind foot skin in rats following resection or crush injury of the sciatic nerve. The initial depletion of SPLI, which occurred in all areas sampled, was simila...

journal_title：Brain research

authors： Bisby MA,Keen P

更新日期：1986-02-12 00:00:00

abstract：:We studied the effects of transcranial magnetic stimulation (TMS) on muscle activation patterns and joint kinematics during oscillatory movements of a joint within a two-joint (elbow-wrist) synergy. Healthy young adults (N=8) performed cyclic movements in one of the joints while the other joint was or was not involved...

journal_title：Brain research

authors： Latash ML,Danion F,Bonnard M

更新日期：2003-01-31 00:00:00

abstract：:These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...

journal_title：Brain research

authors： Quirarte GL,Galvez R,Roozendaal B,McGaugh JL

更新日期：1998-10-19 00:00:00

abstract：:The present study was undertaken to disclose temporal changes in the distribution of Fos-like immunoreactive (-IR) neurons in the trigeminal subnucleus caudalis (SpVc), one of the important relay nuclei for processing the nociceptive information from the oro-facial regions, following induction of experimental tooth mo...

journal_title：Brain research

authors： Aihara Y,Maeda T,Hanada K,Wakisaka S

更新日期：1999-02-20 00:00:00

abstract：:A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition to and surrounding the amyloid plaques. The mechanisms by which the astrocytes become activated in AD and the consequences ...

journal_title：Brain research

authors： Hu J,Akama KT,Krafft GA,Chromy BA,Van Eldik LJ

更新日期：1998-03-02 00:00:00

abstract：:Anticonvulsant mood stabilizers, e.g., valproic acid and carbamazepine, and atypical antipsychotic drugs (APDs), e.g., clozapine, quetiapine, olanzapine, risperidone, and ziprasidone, have been reported to preferentially increase dopamine (DA) release in rat medial prefrontal cortex (mPFC), an effect partially or full...

journal_title：Brain research

authors： Ichikawa J,Dai J,Meltzer HY

更新日期：2005-07-12 00:00:00

abstract：:Hippocampal long-term potentiation (LTP) is considered as a cellular model of memory formation. Specific, electrical weak tetanization of distinct afferents such as the medial perforant path results in a short-lasting, protein synthesis-independent early-LTP (up to 4 h) within the dentate gyrus. A stronger tetanizatio...

journal_title：Brain research

authors： Neugebauer F,Korz V,Frey JU

更新日期：2009-06-01 00:00:00

abstract：:Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra became briefly sedated and hypothermic after the acute injection of nicotine s.c. (0.4 or 0.8 mg/kg free base). When nicotine was repeated 5 days per week there was rapid tolerance for the sedation and slower tolerance for the hypothermia and the l...

journal_title：Brain research

authors： Lapin EP,Maker HS,Sershen H,Hurd Y,Lajtha A

更新日期：1987-03-31 00:00:00

abstract：:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involv...

journal_title：Brain research

authors： Bouilleret V,Boyet S,Marescaux C,Nehlig A

更新日期：2000-01-10 00:00:00

abstract：:Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-L...

journal_title：Brain research

authors： McNamara MJ,Ruff CT,Wasco W,Tanzi RE,Thinakaran G,Hyman BT

更新日期：1998-08-31 00:00:00

abstract：:Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...

journal_title：Brain research

authors： Kirby MT,Hampson RE,Deadwyler SA

更新日期：2000-04-28 00:00:00

abstract：:Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...

journal_title：Brain research

authors： Kalra PS,Norlin M,Kalra SP

更新日期：1995-12-24 00:00:00

abstract：:The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...

journal_title：Brain research

authors： Kafka MS,Marangos PJ,Moore RY

更新日期：1985-02-18 00:00:00