Abstract:
:Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in all five brain regions examined. No changes were observed in the liver. The changes were particularly pronounced in the cortex and in the striatum where enzyme activity increased three-fold during the period studied. KYNA production from its bioprecursor L-kynurenine was also investigated in tissue slices and was found to be significantly enhanced in the cortex and hippocampus of old animals. The effect of depolarizing agents or sodium replacement was virtually identical in tissues from young and old rats. These data, which are in excellent agreement with reports on an age-dependent increase of KYNA concentration in brain tissue, suggest an enhanced KYNA tone in the aged brain. Together with the reported decline in cerebral excitatory amino acid receptor densities with age, increased production of KYNA may play a role in cognitive and memory dysfunction in old animals.
journal_name
Brain Resjournal_title
Brain researchauthors
Gramsbergen JB,Schmidt W,Turski WA,Schwarcz Rdoi
10.1016/0006-8993(92)91337-esubject
Has Abstractpub_date
1992-08-14 00:00:00pages
1-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)91337-Ejournal_volume
588pub_type
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