Abstract:
:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involved in seizures before surgery, this exploration is only performed once the disease has fully developed. Therefore, in the present study, we followed the temporal evolution of intrahippocampal kainate-induced metabolic changes in mice from kainate injection to 120 days later by the quantitative autoradiographic [14C]2-deoxyglucose (2DG) technique. At day 0 (late phase of status epilepticus (SE)) and 15 days after kainate, i.e., during the period of ongoing neuropathological changes, glucose utilization was decreased bilaterally in all parts of the cerebral cortex, and ipsilaterally in the thalamus. In the hippocampus, CA1 metabolic activity was depressed at day 0 and increased at day 15 while CA3 glucose utilization was increased at both day 0 and 15. By day 30, there were almost no pyramidal cells left in the two hippocampal regions. At day 120, ipsilateral decreases persisted in the entorhinal cortex, anterior and ventromedian thalamus, and metabolic increases were recorded bilaterally in the central amygdala, anterior hypothalamus and mamillary body. At all times after kainate, a normo-, hypo- or hypermetabolic level was recorded in the dentate gyrus. The present study shows that the process of hippocampal sclerosis involves bilateral cortical reactivity and the participation of some limbic forebrain and motor structures. When hippocampal sclerosis has fully developed, hypometabolism is limited to regions directly connected to the damaged hippocampus and most likely involved in the new hyperexcitable circuit of limbic seizures.
journal_name
Brain Resjournal_title
Brain researchauthors
Bouilleret V,Boyet S,Marescaux C,Nehlig Adoi
10.1016/s0006-8993(99)02092-2subject
Has Abstractpub_date
2000-01-10 00:00:00pages
255-62issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02092-2journal_volume
852pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We have previously shown that systemic administration of ondansetron, a selective serotonin type-3 (5-HT3) receptor antagonist, attenuates cholecystokinin (CCK)-induced suppression of food intake. The exact location of 5-HT3 receptors mediating this action is not clear and may involve hindbrain 5-HT3 receptors. In thi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.058
更新日期:2006-08-04 00:00:00
abstract::Nerve growth activities in rat sciatic nerves were assayed by recording the neuritic outgrowth from chick embryonic ganglia cultured in collagen gels beside nerve fragments for two days. Living nerve explants released activity that resembled nerve growth factor (NGF) in its effect on sympathetic ganglia and that was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90141-x
更新日期:1982-08-19 00:00:00
abstract::The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90248-8
更新日期:1994-08-01 00:00:00
abstract::Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90076-7
更新日期:1981-04-27 00:00:00
abstract::We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA). Two days after KA, 100 mM KCl induced a 1.6 +/- 0.2-fold increase in NPY release compared to saline-injected rats (P < 0.05), while sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90847-8
更新日期:1994-10-10 00:00:00
abstract::NK1 receptor antagonists have been shown to act centrally and to produce a broad-spectrum anti-emetic action. To determine precisely the site of this action, we microinjected GR205171, an NK1 receptor antagonist, into the left medulla oblongata in decerebrate paralyzed dogs. The right medulla was transected 2.5 mm ros...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01324-9
更新日期:1999-02-13 00:00:00
abstract::Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90941-2
更新日期:1985-12-09 00:00:00
abstract::Ginseng is one of most extensively used traditional oriental medicines worldwide with beneficial efficacy on cognitive function disorders. Pharmacological researches on its active ingredient--ginsenoside Rg1 revealed that it can improve learning and memory potentially via modulating neurotransmission in the central ne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.096
更新日期:2010-05-28 00:00:00
abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03259-0
更新日期:2002-01-18 00:00:00
abstract::The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.017
更新日期:2005-11-23 00:00:00
abstract::Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.037
更新日期:2015-03-10 00:00:00
abstract::The aim of this study was to examine: (1) whether long-term potentiation (LTP) can be induced in slices from adult rat visual cortex under conditions where inhibition is not antagonized, and (2) the role of N-methyl-D-aspartate (NMDA) receptors in its induction. The field potential elicited in layer III in response to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90891-c
更新日期:1992-07-03 00:00:00
abstract::The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.023
更新日期:2012-04-27 00:00:00
abstract::This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90295-8
更新日期:1988-08-30 00:00:00
abstract::The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.081
更新日期:2010-02-08 00:00:00
abstract::Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90318-h
更新日期:1993-11-12 00:00:00
abstract::The polar head group of the phospholipid phosphatidylserine is similar in structure to the glutamate analogue 2-amino-4-phosphonobutyric acid (APB), an antagonist of excitatory transmission in the brain. When tested in ligand binding assays phosphatidylserine and its polar head group components O-phosphoserine and L-a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90328-6
更新日期:1982-06-24 00:00:00
abstract::Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91337-e
更新日期:1992-08-14 00:00:00
abstract:INTRODUCTION:Apathy is the most common neuropsychiatric syndrome in behavioral variant frontotemporal dementia (bvFTD), and encompasses cognitive, behavioral and affective symptoms. The neural basis of apathy in bvFTD is not completely understood. Previous neuroimaging studies have poorly considered executive impairmen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146799
更新日期:2020-06-15 00:00:00
abstract::In order to establish possible stimulatory effects of increasing plasma concentrations of substance P (SP) on the arginine vasopressin (AVP) and/or oxytocin (OT) secretion, successively increasing doses of SP(0.5, 1 and 1.5 pmol/kg-1/min-1; each dose for 20 min) were infused in 7 normal men. Plasma AVP and OT levels w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90387-o
更新日期:1992-01-08 00:00:00
abstract::Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungaro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90493-6
更新日期:1994-08-22 00:00:00
abstract::Ethanol caused a concentration-dependent loss of PC12 cells over a 24 h interval, accompanied by an increase in intracellular calcium. The specific alpha7 nicotinic receptor partial agonist DMXB attenuated both of these ethanol-induced actions at a concentration (3 microM) found previously to protect against apoptotic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01153-6
更新日期:1999-01-16 00:00:00
abstract::While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00726-7
更新日期:1995-09-18 00:00:00
abstract::Glial-cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN) and persephin (PSPN), known as the GDNF family ligands (GFLs), influence the development, survival and differentiation of cultured dopaminergic neurons from ventral mesencephalon (VM). Detailed knowledge about the effects of GFLs on o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.056
更新日期:2006-01-19 00:00:00
abstract::With the increasing worldwide incidence of Alzheimer's disease (AD), there is a critical need for the discovery of more effective diagnostic methods. However, development of diagnostic tools in AD has been hindered by obstacles such as the absence of exact biomarkers. Apoptosis caused by amyloid-β (Aβ) plays an import...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.06.041
更新日期:2016-09-01 00:00:00
abstract::In acute cats deeply anesthetized with Nembutal, monosynaptic excitatory postsynaptic potentials (EPSPs) triggered by stimulation of the ventrolateral (VL) thalamic nucleus and the pes pedunculus were recorded in large pyramidal tract cells (PT cells). Deep anesthesia, low intensities of stimulation and an averaging t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90598-5
更新日期:1979-01-05 00:00:00
abstract::The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90395-2
更新日期:1988-11-01 00:00:00
abstract::The magnetoencephalographic signal was collected in a visually guided response-finger selection GO/NOGO task. The minimum norm distributed source analysis identified the sources in bilateral superior parietal lobules (SPL), with stronger activity for contralateral finger movement. Our results suggest that the human SP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02088-1
更新日期:2001-04-06 00:00:00
abstract::The effect of chronic ethanol administration on the fine structure of the hippocampal CA1 stratum oriens was examined in two lines of mice selectively bred for their differential sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS mice). Two experiments were performed. In the first experiment, mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90718-9
更新日期:1987-04-21 00:00:00
abstract::The N400 is an event-related potential (ERP) component that is elicited by semantically meaningful stimuli; one of its defining characteristics is that it is amplified for sentence completions that are semantically unexpected or incongruous with the preceding context. Some prior reports using visual sentence reading p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.099
更新日期:2010-10-08 00:00:00