Abstract：
:Ethanol caused a concentration-dependent loss of PC12 cells over a 24 h interval, accompanied by an increase in intracellular calcium. The specific alpha7 nicotinic receptor partial agonist DMXB attenuated both of these ethanol-induced actions at a concentration (3 microM) found previously to protect against apoptotic and necrotic cell loss. The alpha7 nicotinic receptor antagonist methylylaconitine blocked the neuroprotective action of DMXB when applied with but not 30 min after the agonist. These results indicate that activation of alpha7 nicotinic receptors may be therapeutically useful in preventing ethanol-neurotoxicity.
journal_name
Brain Resjournal_title
Brain researchauthors
Li Y,King MA,Grimes J,Smith N,de Fiebre CM,Meyer EMdoi
10.1016/s0006-8993(98)01153-6subject
Has Abstractpub_date
1999-01-16 00:00:00pages
225-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01153-6journal_volume
816pub_type
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