Abstract：
:This study investigated the effects of electrical stimulation with theta burst stimulation (eTBS) on seizure suppression. Optimal parameters of eTBS were determined through open-loop stimulation experiments and then implemented in a close-loop seizure control system. For the experiments, 4-aminopyridine (4-AP) was injected into the right hippocampus of Sprague-Dawley rats to induce an acute seizure. eTBS was applied on the ventral hippocampal commissure and the effects of eTBS with different combinations of burst frequency and number of pulses per burst were analyzed in terms of seizure suppression. A closed-loop seizure control system was then implemented based on optimal eTBS parameters. The efficiency of the closed-loop eTBS was evaluated and compared to that of high frequency stimulation. The results show that eTBS induced global suppression in the hippocampus and this was sustained even after the application of eTBS. The optimal parameter of eTBS in the open-loop stimulation experiments was a burst frequency at 100Hz with nine pulses in a burst. The eTBS integrated with the on-off control law yielded less actions and cumulative delivered charge, but induced longer after-effects of seizure suppression compared to continuous high frequency stimulation (cHFS). To conclude, eTBS has suppressive effects on 4-AP induced seizure. A closed-loop eTBS system provides a more effective way of suppressing seizure and requires less effort compared to cHFS. eTBS may be a novel stimulation protocol for effective seizure control.
journal_name
Brain Resjournal_title
Brain researchauthors
Siah BH,Chiang CC,Ju MS,Lin CCdoi
10.1016/j.brainres.2014.10.025subject
Has Abstractpub_date
2014-12-17 00:00:00pages
117-25eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01427-9journal_volume
1593pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Cortical sensory neurons synchronize their activity at multiple frequency bands after an external stimulation. In the somatosensory cortical areas, previous reports describe more discrete and somatotopically specific neural synchronization at the gamma band. Therefore, an efficient gamma synchronization of the neurons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03171-8
更新日期：2003-10-03 00:00:00
abstract：:While trophic support from targets depends on innervation, recent evidence suggests that local VIP promotes survival of sympathetic neuroblasts prior to target interactions, during the period of neurogenesis. Developmental studies now indicate that VIP expression peaks at embryonic day 15.5 (E15.5) in sympathetic gang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90461-8
更新日期：1994-11-07 00:00:00
abstract：:The second phase of Ca2+ transients (aequorin luminescence) which was not accompanied by twitch tensions were generated by 0.3 microM neostigmine in indirectly-stimulated diaphragm muscles of mice. This phase was dependent on external [Ca2+]o, was inhibited by a low concentration of (+)-tubocurarine (+)-TC; 0.013-0.13...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90287-l
更新日期：1990-01-22 00:00:00
abstract：:Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90328-4
更新日期：1989-10-23 00:00:00
abstract：:Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.045
更新日期：2016-11-01 00:00:00
abstract：:parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.065
更新日期：2010-09-17 00:00:00
abstract：:Possible synergistic effects of the glucocorticoid dexamethasone (DEX, 10(-7) M) and the adenylate cyclase agonist forskolin (FSK, 10(-5) M) on [Met5]enkephalin (ME) accumulation were examined in enriched rat glial cultures and in mixed neuronal/glial cultures. In enriched glial cultures, DEX and FSK each stimulated t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00443-x
更新日期：1996-08-19 00:00:00
abstract：:The present study examines comparatively the cellular density of disector-counted/Nissl-stained CA1 pyramidal neurons and the morphometric characteristics (dendritic number/length, spine number/density and Sholl-counted dendritic branch points/20 microm) of the basal and apical dendritic systems of Golgi-impregnated C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.037
更新日期：2008-07-07 00:00:00
abstract：:Using biochemical techniques we determined concentrations of the AMPA-selective glutamate receptor subunits GluR1 and GluR2/3 in the entorhinal cortex of patients with Alzheimer's disease pathology and age-matched controls. Tangle density was also determined in anatomically matched samples and correlated with GluR1 an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00178-s
更新日期：1995-04-24 00:00:00
abstract：:We studied the short- and long-term epileptogenic effects of massed stimulation (MS) of the piriform cortex. Sprague-Dawley rats with electrodes implanted bilaterally in the anterior piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the left piriform cortex every 5 min for 6...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00071-1
更新日期：1997-04-18 00:00:00
abstract：:The spinal cord dorsal horn contains neural mechanisms which can greatly facilitate pain. We have recently shown that 'illness'-inducing agents, such as intraperitoneally administered lipopolysaccharide (LPS; bacterial endotoxin), can produce prolonged hyperalgesia. This hyperalgesic state is mediated at the level of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91948-8
更新日期：1994-11-21 00:00:00
abstract：:Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90592-b
更新日期：1993-10-29 00:00:00
abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90129-7
更新日期：1989-12-25 00:00:00
abstract：:The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91440-0
更新日期：1988-02-23 00:00:00
abstract：:Basic fibroblast growth factor (FGF-2) isoforms of the adrenal medulla are differentially expressed during rat postnatal development. While the 18 and 23 kDa isoforms continuously rise towards the adult expression level, the 21 kDa isoform displays a peak expression at postnatal day 28. The peak expression of the 21 k...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00341-7
更新日期：1997-05-23 00:00:00
abstract：:cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90409-x
更新日期：1994-08-08 00:00:00
abstract：:We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02238-6
更新日期：2000-01-10 00:00:00
abstract：:In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90094-0
更新日期：1987-01-01 00:00:00
abstract：:Transient ischemic attack (TIA) has received only little attention in the experimental research field. Recently, we introduced a TIA model for mice, and here we set similar principles for simulating this human condition in Wistar rats. In the model: 1) transient nature of the event is ensured, and 2) 24h after the eve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.03.010
更新日期：2017-05-15 00:00:00
abstract：:It has been hypothesized that a disruption of gamma-aminobutyric acid (GABA) receptor-mediated processes may be involved in the pathophysiology of focal epilepsy. This disinhibition hypothesis has been postulated from the results of in vitro experiments of the interictal activity of focal epilepsy. Less is known, howe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02209-5
更新日期：2000-05-26 00:00:00
abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03358-9
更新日期：2002-11-01 00:00:00
abstract：:Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.02.026
更新日期：2014-04-04 00:00:00
abstract：:Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02599-4
更新日期：2002-06-14 00:00:00
abstract：:An in vitro radioenzymatic assay and purification procedure by thin-layer chromatography were used to study the metabolism of dihydrotestosterone (DHT) into 3 alpha- and 3 beta-androstanediols by the brain and cloacal gland of Japanese quail. Kinetic studies showed that these 2 metabolites are produced in a linear fas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91280-7
更新日期：1987-09-22 00:00:00
abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.056
更新日期：2007-02-09 00:00:00
abstract：:Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90088-5
更新日期：1993-10-08 00:00:00
abstract：:The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91434-6
更新日期：1994-01-28 00:00:00
abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90615-9
更新日期：1987-09-01 00:00:00
abstract：:The Timm and selenium staining techniques, based on silver amplification of endogenous zinc, produce an electron-dense precipitate in boutons. The staining characteristics of the two methods were compared by examining two allocortical regions, prepiriform cortex and entorhinal cortex, in the brain of the European hedg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90361-0
更新日期：1985-11-25 00:00:00
abstract：:The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01256-0
更新日期：1998-01-19 00:00:00
