Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary.

Abstract:

:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is specific for melatonin, since its analogs N-acetylserotonin and 5-methoxytryptamine are 1000 times less potent. Cyclic nucleotides may thus serve as second messengers transducing the effect of melatonin on cellular level.

journal_name

Brain Res

journal_title

Brain research

authors

Vanĕcek J,Vollrath L

doi

10.1016/0006-8993(89)90129-7

subject

Has Abstract

pub_date

1989-12-25 00:00:00

pages

157-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90129-7

journal_volume

505

pub_type

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