Abstract:
:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is specific for melatonin, since its analogs N-acetylserotonin and 5-methoxytryptamine are 1000 times less potent. Cyclic nucleotides may thus serve as second messengers transducing the effect of melatonin on cellular level.
journal_name
Brain Resjournal_title
Brain researchauthors
Vanĕcek J,Vollrath Ldoi
10.1016/0006-8993(89)90129-7subject
Has Abstractpub_date
1989-12-25 00:00:00pages
157-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90129-7journal_volume
505pub_type
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