Abstract：
:The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activity and rearing) was measured in an open-field after bilateral AP5 injection into the hippocampus, and it was shown that AP5 did not affect general activities within the dosage used in the present study. In Expt. 2, radial-maze performance was observed after the intrahippocampal injection of AP5. Rats were required to consume all the pellets which were put on each of the eight arms of the maze without revisiting the arms. AP5 produced dose-dependent impairment on the choice performance in the radial-arm maze, but did not have any effect on their running time. These results suggest that hippocampal NMDA receptors are involved in spatial memory.
journal_name
Brain Resjournal_title
Brain researchauthors
Kawabe K,Ichitani Y,Iwasaki Tdoi
10.1016/s0006-8993(97)01256-0subject
Has Abstractpub_date
1998-01-19 00:00:00pages
300-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01256-0journal_volume
781pub_type
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