Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats.

abstract：:Previous studies we performed on the mdx mouse demonstrated marked central nervous system alterations in this model of human Duchenne muscular dystrophy, such as reduction in number and pathological changes of cortico-spinal neurons. Prompted by these findings we extended the survey of the mdx brain to the major brain...

journal_title：Brain research

authors： Carretta D,Santarelli M,Vanni D,Carrai R,Sbriccoli A,Pinto F,Minciacchi D

更新日期：2001-03-23 00:00:00

abstract：:Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and re...

journal_title：Brain research

authors： Roffler-Tarlov S,Herrup K

更新日期：1981-06-29 00:00:00

abstract：:Influence of dopamine agonists, methamphetamine (MAT, 1 mg/kg, i.p.) and apomorphine (APO, 1 mg/kg, i.p.), on the effects of amygdaloid lesions on thresholds for the defensive attack behavior elicited by electrical stimulation of the ventromedial hypothalamic nucleus was studied in cats. The thresholds were measured i...

journal_title：Brain research

authors： Maeda H,Maki S

更新日期：1986-01-15 00:00:00

abstract：:Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...

journal_title：Brain research

authors： Rahner N,Holzmann C,Krüger R,Schöls L,Berger K,Riess O

更新日期：2002-09-27 00:00:00

abstract：:Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Where...

journal_title：Brain research

authors： Bourgoin S,Pohl M,Benoliel JJ,Mauborgne A,Collin E,Hamon M,Cesselin F

更新日期：1992-06-26 00:00:00

abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...

journal_title：Brain research

authors： Yamuy J,Engelhardt JK,Morales FR,Chase MH

更新日期：1992-01-20 00:00:00

abstract：:Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i....

journal_title：Brain research

authors： Mondaca M,Hernández A,Pérez H,Valladares L,Sierralta W,Fernández V,Soto-Moyano R

更新日期：2004-09-24 00:00:00

abstract：:The opioid peptides Leu-enkephalin, Met-enkephalin and D-Ala2-Met-enkephalinamide were injected at various concentrations into the neocortex and hippocampus of rats to examine their effects on EEG activity and DC potentials. All three compounds were found to elicit spreading depression (SD) in both structures. Higher ...

journal_title：Brain research

authors： Sprick U,Oitzl MS,Ornstein K,Huston JP

更新日期：1981-04-06 00:00:00

abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...

journal_title：Brain research

authors： Xie D,Croaker GDH,Li J,Song ZM

更新日期：2016-07-01 00:00:00

abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...

journal_title：Brain research

authors： Sim LJ,Selley DE,Tsai KP,Morris M

更新日期：1994-07-18 00:00:00

abstract：:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...

journal_title：Brain research

authors： Crespi F,Sharp T,Maidment NT,Marsden CA

更新日期：1984-11-19 00:00:00

abstract：:Lithium is detected in the mouse brain with the aid of a (n,alpha) nuclear reaction. The resolving power is of a few micron. The detection efficiency is estimated in a first series of experiments with brain sections of progressively increasing thickness. This allows us to make the microlocation of lithium in the brain...

journal_title：Brain research

authors： Thellier M,Heurteaux C,Wissocq JC

更新日期：1980-10-13 00:00:00

abstract：:Intracellular Ca2+ concentration ([Ca2+]i) was measured in neurons, acutely dissociated from the rat dorsal raphe nucleus (DRN), with the fluorescent calcium probe Fluo3. Nociceptin (300 nM) had no effect on resting [Ca2+]i but reduced the magnitude of the [Ca2+]i transient triggered by depolarization in 90% of neuron...

journal_title：Brain research

authors： Roumy M,Zajac J

更新日期：1999-10-23 00:00:00

abstract：:It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and dir...

journal_title：Brain research

authors： Tehovnik EJ,Slocum WM

更新日期：2000-09-15 00:00:00

abstract：:Current and voltage responses elicited by increasing or decreasing the concentration of L-glutamate or its analog kainate around isolated cone horizontal cells were measured with patch pipettes using the whole cell recording configuration. Application of these photoreceptor transmitter agonists induced inward currents...

journal_title：Brain research

authors： Perlman I,Knapp AG,Dowling JE

更新日期：1989-05-15 00:00:00

abstract：:The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...

journal_title：Brain research

authors： Kashihara K,Hamamura T,Okumura K,Otsuki S

更新日期：1990-09-24 00:00:00

abstract：:Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the administration of the hepa...

journal_title：Brain research

authors： Swapna I,SathyaSaikumar KV,Murthy ChR,Gupta AD,Senthilkumaran B

更新日期：2007-06-11 00:00:00

abstract：:About 45% of the serotonergic raphe neurons are reported to express nerve growth factor (NGF) receptors. We therefore investigated whether selective serotonergic lesions of the median or dorsal raphe nuclei are associated with changes in NGF protein levels of the brain and whether the loss of serotonergic function alt...

journal_title：Brain research

authors： Hellweg R,Thomas H,Arnswald A,von Richthofen S,Kay S,Fink H,Morgenstern R,Hörtnagl H

更新日期：2001-07-13 00:00:00

abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...

journal_title：Brain research

authors： González-Mariscal G,García Dalmán C,Jiménez A

更新日期：2015-05-22 00:00:00

abstract：:The medial preoptic nucleus (MPN) of the medial preoptic area (MPOA) and the medial amygdala are two brain regions in which male rat sexual behavior increased Fos-like immunoreactivity (Fos-Li). Dopamine is released in the MPOA during male rat sexual behavior and facilitates copulation. Psychostimulants, which increas...

journal_title：Brain research

authors： Lumley LA,Hull EM

更新日期：1999-05-22 00:00:00

abstract：:(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...

journal_title：Brain research

authors： Kucharczyk J,Assaf SY,Mogenson GJ

更新日期：1976-05-28 00:00:00

abstract：:The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...

journal_title：Brain research

authors： Garcia-Rill E,Nieto A,Adinolfi A,Hull CD,Buchwald NA

更新日期：1979-07-20 00:00:00

abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...

journal_title：Brain research

authors： Steimer T,Hutchison JB

更新日期：1989-02-20 00:00:00

abstract：:Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

journal_title：Brain research

authors： Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

更新日期：2013-01-23 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-like immunoreactivity was examined in the rat olfactory bulb by an immunohistochemical method using antiserum against the tripeptide TRH. TRH-immunoreactive neurons and neuronal processes were localized in both main and accessory olfactory bulb, including the glomerular layer, exter...

journal_title：Brain research

authors： Tsuruo Y,Hökfelt T,Visser TJ

更新日期：1988-04-26 00:00:00

abstract：:Rabbits passively oscillated in the horizontal plane with a free hand tended to stabilize their head in space (re: earth-fixed surroundings) by moving the head on the trunk (neck angular deviation, NAD) opposite the passively imposed body rotation. The gain (NAD/body rotation) of head stabilization varied from 0.0 to ...

journal_title：Brain research

authors： Fuller JH

更新日期：1981-02-02 00:00:00

abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...

journal_title：Brain research

authors： Staub F,Peters J,Kempski O,Schneider GH,Schürer L,Baethmann A

更新日期：1993-04-30 00:00:00

abstract：:Unlike the basal ganglia input from the midline and intralaminar nuclei, the origin and prominence of striatal projections arising in the lateral thalamus varies considerably among mammals being most restricted in the opossum and monkey, most extensive in the rat. To get further insight into the evolution of thalamo-s...

journal_title：Brain research

authors： Künzle H

更新日期：2006-07-19 00:00:00

abstract：:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...

journal_title：Brain research

authors： Thompson JM

更新日期：1982-07-01 00:00:00

abstract：:Growth hormone (GH) suppresses its own secretion by stimulating somatostatin (SRIF) release. Thus, the possible regulation of GH-releasing factor (GRF) and SRIF release and SRIF messenger ribonucleic acid (mRNA) by GH was studied in the hypothalamus of male rats in vitro. The median eminences (ME's) were incubated in ...

journal_title：Brain research

authors： Aguila MC,McCann SM

更新日期：1993-09-24 00:00:00