Abstract：
:Previous studies we performed on the mdx mouse demonstrated marked central nervous system alterations in this model of human Duchenne muscular dystrophy, such as reduction in number and pathological changes of cortico-spinal neurons. Prompted by these findings we extended the survey of the mdx brain to the major brainstem-descending pathways: the rubro-, vestibulo-, reticulo-, and raphe-spinal projections. Horseradish peroxidase microinjections were performed in the cervical spinal cord of mdx and control mice. The rubro-spinal neurons were found to be significantly reduced in mutants compared to controls. The vestibulo-spinal, reticulo-spinal, and raphe-spinal cell populations, though less numerous in mdx than in control mice, were instead substantially spared. Our data further unveil the selective nature of mdx brain damage indicating a marked and selective involvement of the highest centers for motor control.
journal_name
Brain Resjournal_title
Brain researchauthors
Carretta D,Santarelli M,Vanni D,Carrai R,Sbriccoli A,Pinto F,Minciacchi Ddoi
10.1016/s0006-8993(01)02108-4subject
Has Abstractpub_date
2001-03-23 00:00:00pages
213-22issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02108-4journal_volume
895pub_type
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