Pre- and postsynaptic actions of valproic acid at the frog neuromuscular junction.

abstract：:This study examined whether cardiac beta-adrenoceptor (beta-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) beta(1,2)-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) beta(3)- and/or atypical beta-AR-mediated tach...

journal_title：Brain research

authors： Whalen EJ,Schoorlemmer GH,Beltz TG,Johnson AK,Lewis SJ

更新日期：2001-09-14 00:00:00

abstract：:We investigated the ability of GM1 to induce phosphorylation/activation of the extracellular-regulated protein kinases (ERKs) in the striatum, hippocampus and frontal cortex of aged male Sprague-Dawley rats. Three different treatment paradigms were used: a single application of GM1 to brain slices in situ, a single in...

journal_title：Brain research

authors： Mo L,Ren Q,Duchemin AM,Neff NH,Hadjiconstantinou M

更新日期：2005-08-30 00:00:00

abstract：:Effects of systemic administration of a single dose (50 mg/kg) of ethosuximide (ESM) on extracellularly recorded thalamic (nucleus centralis lateralis, CL; nucleus reticularis, RE) and cortical neurons and on cortical EEG activity of acute cats, have been studied. In intact animals ESM led to: (a) desynchronization of...

journal_title：Brain research

authors： Pellegrini A,Dossi RC,Dal Pos F,Ermani M,Zanotto L,Testa G

更新日期：1989-09-18 00:00:00

abstract：:Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...

journal_title：Brain research

authors： McGuire B,Fiorillo B,Ryugo DK,Lauer AM

更新日期：2015-04-24 00:00:00

abstract：:Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...

journal_title：Brain research

authors： Elble RJ,Schieber MH,Thach WT Jr

更新日期：1984-12-10 00:00:00

abstract：:Electroconvulsive therapy (ECT) is widely used as a treatment for drug-resistant depression. The animal analogue of ECT is electroconvulsive shock (ECS) seizures. We have recently shown that repeated ECS seizures cause a long-lasting, perhaps permanent, enhancement in entorhinal-dentate evoked potentials in the rat. O...

journal_title：Brain research

authors： Gombos Z,Mendonça A,Racine RJ,Cottrell GA,Burnham WM

更新日期：1997-08-22 00:00:00

abstract：:Injections of HRP throughout the upper tectal strata led in 4 cases to the appearance of retrogradely labeled neurons within n.isthmi ventralis, contralateral to the experimental side. An additional case proved that this projection courses through the ventral supraoptic commissure. This is the first description of a c...

journal_title：Brain research

authors： Martínez S,Puelles L

更新日期：1989-02-27 00:00:00

abstract：:Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

journal_title：Brain research

authors： Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

更新日期：2013-01-23 00:00:00

abstract：:Intravenous administration of the cholecystokinin (CCK) antagonist lorglumide (LORG) reversed chronic haloperidol (CHAL)-induced depolarization inactivation (DI) of dopamine (DA) cells in both the A9 and A10 areas. Moreover, microinjection of LORG, but not naloxone, directly into the medial nucleus accumbens (mNAc) do...

journal_title：Brain research

authors： Jiang LH,Kasser RJ,Wang RY

更新日期：1988-11-08 00:00:00

abstract：:The effect of 4% ethanol on pacemaker currents of Aplysia neurons was studied under voltage clamp. In normal seawater the n-shape in the I-V disappeared and outward current increased. Ion substitution and drug blocking experiments determined that leakage current and the slow inward calcium current were decreased and t...

journal_title：Brain research

authors： Schwartz MH

更新日期：1983-11-14 00:00:00

abstract：:Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal C...

journal_title：Brain research

authors： Hirsh JK,Quandt FN

更新日期：1996-01-15 00:00:00

abstract：:The purpose of this study was to identify the CNS cellular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure and non-seizure rat brain. Analysis of P2X7 immunocytochemistry (ICC) revealed small immunoreactive cells with processes showing distinct morphological changes as se...

journal_title：Brain research

authors： Rappold PM,Lynd-Balta E,Joseph SA

更新日期：2006-05-17 00:00:00

abstract：:By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant i...

journal_title：Brain research

authors： Ikeda M,Houtani T,Nakagawa H,Baba K,Kondoh A,Ueyama T,Yamamoto T,Gemba H,Sugimoto T

更新日期：1995-09-04 00:00:00

abstract：:The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...

journal_title：Brain research

authors： Low WC,Lewis PR,Terri ST

更新日期：1983-03-07 00:00:00

abstract：:The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in ...

journal_title：Brain research

authors： Innis SM

更新日期：2008-10-27 00:00:00

abstract：:Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...

journal_title：Brain research

authors： Brooke SM,de Haas-Johnson AM,Kaplan JR,Sapolsky RM

更新日期：1994-02-21 00:00:00

abstract：:The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, beha...

journal_title：Brain research

authors： Cubero I,Puerto A

更新日期：2000-07-14 00:00:00

abstract：:We investigated the effect of adenosine A1 receptors on the release of acetylcholine (ACh) and GABA, and on the intracellular calcium concentration ([Ca2+]i) response in cultured chick amacrine-like neurons, stimulated by KCl depolarization. The KCl-induced release of [3H]ACh, but not the release of [14C]GABA, was pot...

journal_title：Brain research

authors： Santos PF,Caramelo OL,Carvalho AP,Duarte CB

更新日期：2000-01-03 00:00:00

abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...

journal_title：Brain research

authors： Ando M,Kato T,Tanaka R,Nagata Y

更新日期：1986-05-14 00:00:00

abstract：:Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-sp...

journal_title：Brain research

authors： Di Domenico F,Casalena G,Sultana R,Cai J,Pierce WM,Perluigi M,Cini C,Baracca A,Solaini G,Lenaz G,Jia J,Dziennis S,Murphy SJ,Alkayed NJ,Butterfield DA

更新日期：2010-11-29 00:00:00

abstract：:The purpose of this study was to investigate the influence of different adenosine triphosphate (ATP) concentrations (ranging from 400 nM to 250 microM) on hippocampal potentials recorded from pyramidal neurons. ATP applied at a concentration of 400 nM induced a 100% increase in the size of the population spike (potent...

journal_title：Brain research

authors： Wieraszko A,Seyfried TN

更新日期：1989-07-10 00:00:00

abstract：:Exposure of hippocampal slices to Mg2+ free media (0 Mg) has been shown to trigger full production of stimulus-induced seizure activity after restoration of physiological conditions [1]. In the present study employing hippocampal entorhinal cortical slices (HEC), spontaneous epileptiform discharges (SEDs) were induced...

journal_title：Brain research

authors： Vick RS,Rafiq A,Coulter DA,Jakoi ER,DeLorenzo RJ

更新日期：1996-05-20 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is susceptible to proteolysis by a calcium-activated neutral protease which is located in myelin. The conversion of MAG (M(r) 100,000) to its soluble derivative dMAG (M(r) 90,000) occurs much more rapidly in myelin from human white matter than in myelin from rat brain, and the rate...

journal_title：Brain research

authors： Möller JR

更新日期：1996-11-25 00:00:00

abstract：:Systemic effects of anesthesia on the dynamics of the apnea-induced Blood Oxygen Level Dependent (BOLD) signal is still not clear. In the present study, the dynamics of the fMRI-BOLD signal and blood flow using laser Doppler flowmetry (LDF) was studied in rats in response to apnea. Two anesthetics namely pentobarbital...

journal_title：Brain research

authors： Kannurpatti SS,Biswal BB

更新日期：2004-06-18 00:00:00

abstract：:The aim of this study is to verify whether anatomical changes occur in the brains of chess players. Besides, it is a potential attempt to evaluate diffusion properties along the tracts due to the diverse situations at anatomical level in different locations; moreover, conventional voxel-based analysis (VBA) has alread...

journal_title：Brain research

authors： Zhou S,Jin L,He J,Zeng Q,Wu Y,Cao Z,Feng Y

更新日期：2018-12-01 00:00:00

abstract：:To elucidate the generation mechanisms of interictal spikes we analyzed the electrical events in the different layers of the rabbit's neocortex after application of penicillin to distinct cortical layers. Field potentials (FP) recorded simultaneously from all layers with a 16-fold micro-electrode-assembly were subject...

journal_title：Brain research

authors： Pockberger H,Rappelsberger P,Petsche H

更新日期：1984-09-10 00:00:00

abstract：:Beta-amyloid (Aβ)-mediated inflammation plays a critical role in the initiation and progression of Alzheimer׳s disease (AD). Anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of hydroxy-safflor yellow A (HSYA) on Aβ1-42-induced inflammation in AD mice was investigated and the unde...

journal_title：Brain research

authors： Zhang ZH,Yu LJ,Hui XC,Wu ZZ,Yin KL,Yang H,Xu Y

更新日期：2014-05-14 00:00:00

abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...

journal_title：Brain research

authors： Marsh KE,Creutz LM,Hawkins MB,Godwin J

更新日期：2006-12-18 00:00:00

abstract：:The effects of duloxetine were examined on cloned Kv4.3 channels stably expressed in CHO cells using the whole-cell patch-clamp technique. Duloxetine decreased the peak amplitude of Kv4.3 currents with an acceleration of the decay rate of current inactivation in a concentration-dependent manner. The IC(50) values requ...

journal_title：Brain research

authors： Choi JS,Hahn SJ

更新日期：2012-07-23 00:00:00

abstract：:Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...

journal_title：Brain research

authors： Beattie CE,Kolb SJ

更新日期：2018-08-15 00:00:00