Abstract：
:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory amino acid aspartate was not affected by the diethylmaleate administration. These results suggested that part of the elevated glutamate content induced by ischemia might result from the cellular GSH.
journal_name
Brain Resjournal_title
Brain researchauthors
Yang CS,Lin NN,Liu L,Tsai PJ,Kuo JSdoi
10.1016/0006-8993(95)00992-ysubject
Has Abstractpub_date
1995-11-06 00:00:00pages
237-40issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00992-Yjournal_volume
698pub_type
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