Abstract:
:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is improved and the size of the 5HIAA peak decreased by the removal of uric acid using the enzyme uricase indicating that uric acid oxidation may contribute to the oxidation peak at + 300 mV. Haloperidol (0.5 mg/kg) decreased ascorbic acid and 5HIAA but increased DOPAC and HVA while D-amphetamine (3 mg/kg) increased ascorbic acid, decreased DOPAC and HVA but had no effect on 5HIAA. These electrodes should be a useful means of investigating interactions between dopamine and serotoninergic systems in vivo.
journal_name
Brain Resjournal_title
Brain researchauthors
Crespi F,Sharp T,Maidment NT,Marsden CAdoi
10.1016/0006-8993(84)91192-2subject
Has Abstractpub_date
1984-11-19 00:00:00pages
135-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)91192-2journal_volume
322pub_type
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