Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum.

Abstract:

:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is improved and the size of the 5HIAA peak decreased by the removal of uric acid using the enzyme uricase indicating that uric acid oxidation may contribute to the oxidation peak at + 300 mV. Haloperidol (0.5 mg/kg) decreased ascorbic acid and 5HIAA but increased DOPAC and HVA while D-amphetamine (3 mg/kg) increased ascorbic acid, decreased DOPAC and HVA but had no effect on 5HIAA. These electrodes should be a useful means of investigating interactions between dopamine and serotoninergic systems in vivo.

journal_name

Brain Res

journal_title

Brain research

authors

Crespi F,Sharp T,Maidment NT,Marsden CA

doi

10.1016/0006-8993(84)91192-2

subject

Has Abstract

pub_date

1984-11-19 00:00:00

pages

135-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)91192-2

journal_volume

322

pub_type

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