Abstract：
:Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related activity, including neurons that responded to the auditory stimulus (signal-related cells), the lever-release (response-related cells), or both of these events (signal/response-related cells). Histological analysis revealed a predominance of signal-related neurons in medial striatum, whereas lateral recording sites mainly showed response-related activity. Haloperidol (0.1 mg/kg s.c.), a widely used neuroleptic that impairs CAR performance, significantly attenuated task-related neural activity without altering the latency of the neural response or spontaneous firing rate. Collectively, these results, which demonstrate the usefulness of the lever-release CAR paradigm for assessing striatal function, suggest that the sensory and motor aspects of the CAR task are processed by different striatal regions. Moreover, haloperidol appears to disrupt the striatal processing of both sensory and motor information.
journal_name
Brain Resjournal_title
Brain researchauthors
White IM,Rebec GVdoi
10.1016/0006-8993(93)90194-rsubject
Has Abstractpub_date
1993-07-09 00:00:00pages
71-82issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90194-Rjournal_volume
616pub_type
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