Concerted and predictable acquisition of glial fibrillary acidic protein filaments by a cohort of astroblasts in culture.

abstract：:This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...

journal_title：Brain research

authors： Sarrieau A,Dussaillant M,Sapolsky RM,Aitken DH,Olivier A,Lal S,Rostène WH,Quirion R,Meaney MJ

更新日期：1988-02-23 00:00:00

abstract：:The second phase of Ca2+ transients (aequorin luminescence) which was not accompanied by twitch tensions were generated by 0.3 microM neostigmine in indirectly-stimulated diaphragm muscles of mice. This phase was dependent on external [Ca2+]o, was inhibited by a low concentration of (+)-tubocurarine (+)-TC; 0.013-0.13...

journal_title：Brain research

authors： Kimura I,Kondoh T,Kimura M

更新日期：1990-01-22 00:00:00

abstract：:The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...

journal_title：Brain research

authors： Farkas E,de Wilde MC,Kiliaan AJ,Meijer J,Keijser JN,Luiten PG

更新日期：2002-11-01 00:00:00

abstract：:The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...

journal_title：Brain research

authors： Clayton JS,Gaskin PJ,Beattie DT

更新日期：1997-11-14 00:00:00

abstract：:Acute and chronic abuses of psychostimulant drugs such as methamphetamine (METH) have been known to cause cell death. In particular, neurotoxicity caused by such drugs is one of the most serious adverse events in humans. Although various effects on neuronal cells caused by METH have been studied, the cellular and mole...

journal_title：Brain research

authors： Nara A,Aki T,Funakoshi T,Uemura K

更新日期：2010-09-17 00:00:00

abstract：:An animal model of self-sustaining status epilepticus (SSSE) induced in rats by brief intermittent perforant path stimulation (PPS) was examined with regard to the effects of two conventional antiepileptic drugs, diazepam and phenytoin. Thirty or sixty minutes PPS induced SSSE characterized by continuous behavioral an...

journal_title：Brain research

authors： Mazarati AM,Baldwin RA,Sankar R,Wasterlain CG

更新日期：1998-12-14 00:00:00

abstract：:We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...

journal_title：Brain research

authors： Abe K,Sugiura M,Shoyama Y,Saito H

更新日期：1998-03-16 00:00:00

abstract：:Ultrastructural localization of a calcium-binding protein, calretinin, in the cerebellar cortex of the rat was examined with an immunoperoxidase method. The cerebellar lobule V was investigated in detail. In the molecular layer, calretinin immunoreactivity was found in parallel fibers and in their varicosities that fo...

journal_title：Brain research

authors： Arai R,Jacobowitz DM,Deura S

更新日期：1993-06-11 00:00:00

abstract：:The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...

journal_title：Brain research

authors： Parent A,Csonka C,Etienne P

更新日期：1984-01-16 00:00:00

abstract：:Our previous studies indicated that L-type calcium channel blocker diltiazem could potentiate pentobarbital-induced hypnosis through serotonergic system. In view of the important role of dorsal raphe nucleus (DRN) on the sleep regulation and the pharmacological actions of calcium channel blocker, we presumed that Ca(2...

journal_title：Brain research

authors： Cui SY,Cui XY,Zhang J,Wang ZJ,Yu B,Sheng ZF,Zhang XQ,Shi XL,Zhang YH

更新日期：2011-07-27 00:00:00

abstract：:Previous lectin-histochemical and immunocytochemical investigations using fixed tissue revealed perineuronal nets as lattice-like accumulations of extracellular matrix proteoglycans at the surface of several types of neurons. In the present study, perineuronal nets in the rat brain were labelled for the first time in ...

journal_title：Brain research

authors： Brückner G,Bringmann A,Köppe G,Härtig W,Brauer K

更新日期：1996-05-13 00:00:00

abstract：:Primary rat neuronal cultures can be preconditioned against ischemic damage by several mechanisms. In the present study we established a new model system in order to characterize the "time window of protection' obtained by preconditioning of neurons with adenosine. Ischemia was simulated by exposure of the cultures to...

journal_title：Brain research

authors： Reshef A,Sperling O,Zoref-Shani E

更新日期：1996-11-25 00:00:00

abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...

journal_title：Brain research

authors： Ventura AL,Paes de Carvalho R

更新日期：1987-09-01 00:00:00

abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...

journal_title：Brain research

authors： Saybasili H

更新日期：1998-03-09 00:00:00

abstract：:Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise effects have not yet been determined. Voltage-dependent Ca2+ ...

journal_title：Brain research

authors： Endoh T

更新日期：2006-09-19 00:00:00

abstract：:The same cells in both the intact retina and retinal cultures of the rabbit retina take up exogenous serotonin or 5,7-dihydroxytryptamine. Both substances can be localised by immunohistochemistry using a monoclonal antibody directed against serotonin. The 5,7-dihydroxytryptamine can also be revealed directly in both f...

journal_title：Brain research

authors： Osborne NN,Beaton DW

更新日期：1986-09-10 00:00:00

abstract：:Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...

journal_title：Brain research

authors： Itier RJ,Alain C,Kovacevic N,McIntosh AR

更新日期：2007-10-26 00:00:00

abstract：:Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the e...

journal_title：Brain research

authors： Lewis VA,Gebhart GF

更新日期：1977-03-25 00:00:00

abstract：:The localization of a GTP-binding protein (G(o)) in the cerebellar and cerebral cortex and hippocampus of the normal and reeler mutant mouse was immunohistochemically examined using affinity-purified antibody raised against the alpha subunit of G(o). Although the general distribution pattern of G(o)-immunoreactive pro...

journal_title：Brain research

authors： Terashima T,Katada T,Ichikawa R,Ui M,Inoue Y

更新日期：1993-01-22 00:00:00

abstract：:Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsuline...

journal_title：Brain research

authors： Plagemann A,Harder T,Rake A,Melchior K,Rohde W,Dörner G

更新日期：1999-02-06 00:00:00

abstract：:We have previously reported the first successful production of monoclonal antibodies against the cholinergic neuronal marker, choline acetyltransferase (ChAT). We now report some inter-and intraspecies cross-reactivity studies of the monoclonal antibody AB1. This antibody reacted most strongly with bovine ChAT and wea...

journal_title：Brain research

authors： Levey AI,Wainer BH

更新日期：1982-02-25 00:00:00

abstract：:Mammalian vestibular type I hair cells (VIHCs) are innervated by an afferent synaptic calyx which contains vesicles and is immunoreactive for GABA. We describe here the effects of GABA on electrophysiological properties and on cytosolic free-calcium levels ([Ca2+]i) of VIHCs isolated from guinea-pig ampullae. Whole-ce...

journal_title：Brain research

authors： Lapeyre PN,Kolston PJ,Ashmore JF

更新日期：1993-04-23 00:00:00

abstract：:Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain th...

journal_title：Brain research

authors： Savory J,Huang Y,Herman MM,Reyes MR,Wills MR

更新日期：1995-01-16 00:00:00

abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...

journal_title：Brain research

authors： Cooper B,Werner HB,Flügge G

更新日期：2008-03-04 00:00:00

abstract：:Experimental traumatic brain injury (TBI) is known to produce an acute increase in cerebral glucose utilization, followed rapidly by a generalized cerebral metabolic depression. The current studies determined effects of single or multiple treatments with sodium pyruvate (SP; 1000mg/kg, i.p.) or ethyl pyruvate (EP; 40m...

journal_title：Brain research

authors： Moro N,Ghavim SS,Harris NG,Hovda DA,Sutton RL

更新日期：2016-07-01 00:00:00

abstract：:In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve hea...

journal_title：Brain research

authors： Frank S,Laharnar N,Kullmann S,Veit R,Canova C,Hegner YL,Fritsche A,Preissl H

更新日期：2010-09-02 00:00:00

abstract：:The caudodorsal cells (CDCs) of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying associated behaviours by releasing various peptides including the ovulation hormone CDCH. Previously it has been shown that release occurs (1) into the haemolymph from neurohaemal axon terminals in the outer compar...

journal_title：Brain research

authors： Schmidt ED,Roubos EW

更新日期：1989-06-12 00:00:00

abstract：:In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...

journal_title：Brain research

authors： Park SY,Lee JH,Kim CD,Rhim BY,Hong KW,Lee WS

更新日期：2007-07-09 00:00:00

abstract：:Immunocytochemical localization of specific neurotransmitters in the brain is becoming increasingly important in studies of maturation. We have used the trilaminar prepyriform cortex (PC) of rats to study the distribution, patterns and relative number of cells, fibers and terminals during postnatal development using a...

journal_title：Brain research

authors： Westenbroek RE,Westrum LE,Hendrickson AE,Wu JY

更新日期：1987-08-01 00:00:00

abstract：:The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...

journal_title：Brain research

authors： Navigatore-Fonzo L,Castro A,Pignataro V,Garraza M,Casais M,Anzulovich AC

更新日期：2017-04-01 00:00:00