Abstract:
:Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsulinemia were observed, accompanied by an increased number of galanin-positive neurons in the PVN at weaning. Our results might indicate malformation of hypothalamic galaninergic neurons due to neonatal overfeeding and hyperinsulinism, respectively, in rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Plagemann A,Harder T,Rake A,Melchior K,Rohde W,Dörner Gdoi
10.1016/s0006-8993(98)01264-5subject
Has Abstractpub_date
1999-02-06 00:00:00pages
160-3issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01264-5journal_volume
818pub_type
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