Abstract:
:The properties of junctions formed de novo in ectopic regions of muscle were studied and compared to those of endplates reinnervated after nerve crush and to normals. The nerve to the frog cutaneous pectoris muscle was transposed and implanted onto an endplate-free (ectopic) region of that muscle, while the endplate-containing portion was excised. New synapses, which subsequently formed in the remaining muscle segment, were studied morphologically and physiologically at postoperative times from approximately 3 weeks to a year. Junctions formed de novo consisted of numerous small contacts, and were only 15% as long as those in control groups. Yet, quantal contents were 2.5-4.7 times larger at de novo junctions.
journal_name
Brain Resjournal_title
Brain researchauthors
Ding Rdoi
10.1016/0006-8993(82)90673-4subject
Has Abstractpub_date
1982-12-16 00:00:00pages
57-63issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90673-4journal_volume
253pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01082-3
更新日期:1999-03-13 00:00:00
abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90284-0
更新日期:1982-01-28 00:00:00
abstract:OBJECTIVE:Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.074
更新日期:2009-01-23 00:00:00
abstract::We investigated the responses of putative aortic baroreceptor neurons to mechanical stimulation of their processes. Putative aortic baroreceptor neurons were identified by applying the carbocyanine dye DiI to the adventitia of the aortic arch of anesthetized rats. After at least 1 week, the nodose ganglia were removed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00153-4
更新日期:1997-05-16 00:00:00
abstract::The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90467-4
更新日期:1981-05-18 00:00:00
abstract::The disector method was used to estimate the numerical density of neurons (number per unit volume) and their actual number per column (number under a given area of pial surface), in the occipital (monocular segment of the primary visual area, Oc1M), the parietal (somatosensory barrelfield area, Par1) and the frontal c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90884-p
更新日期:1993-04-23 00:00:00
abstract::In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02276-3
更新日期:2000-01-31 00:00:00
abstract::A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02061-3
更新日期:2001-03-23 00:00:00
abstract::The present study aimed to determine the kinetics of L-3, 4-dihydroxyphenylalanine (L-DOPA) uptake in an immortalised cell line of rat capillary cerebral endothelial cells (clones RBE 4 and RBE 4B), to define the type of inhibition produced by L-5-hydroxytryptophan (L-5-HTP), 2-aminobicyclo(2,2,1)-heptane-2-carboxylic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01387-6
更新日期:1999-05-22 00:00:00
abstract::Inorganic mercury (Hg2+) reduced voltage-gated calcium channel currents irreversibly in two different preparations. In cultured rat dorsal root ganglion (DRG) neurons, studied with the whole cell patch clamp technique, a rapid concentration-dependent decrease in the L/N-type currents to a steady state was observed wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91146-j
更新日期:1993-12-31 00:00:00
abstract::Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90951-9
更新日期:1982-10-28 00:00:00
abstract::Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90510-5
更新日期:1987-11-10 00:00:00
abstract::Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.04.053
更新日期:2016-10-01 00:00:00
abstract::This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01700-x
更新日期:1999-08-07 00:00:00
abstract::The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal exc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.068
更新日期:2007-03-23 00:00:00
abstract::Electrical activities of thin hippocampal sections of the guinea pig were studied in vitro during and after administration of black widow spider venom (BSV). In CA3 neurons, BSV induced spontaneous discharges which were suppressed by Co2+ or Mn2+. During BSV administration, trains of potential changes resembling excit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90103-2
更新日期:1982-07-29 00:00:00
abstract::We immunocytochemically examined the effect of chronic salt loading on the content of calretinin, a calcium-binding protein, in both the supraoptic nucleus and the magnocellular parts of the hypothalamic paraventricular nucleus. In control rats that were given water for drinking, the supraoptic nucleus contained a clu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00003-9
更新日期:1995-03-06 00:00:00
abstract::The microdialysis technique was utilized to study the effects of N-methyl-D-aspartate (NMDA) receptor ligands on the in vivo release of endogenous glutamate (Glu) and aspartate (Asp) from the rat striatum. Addition of NMDA (250 and 500 microM) to the dialysis perfusion solution resulted in a striking dose-dependent in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91195-k
更新日期:1992-07-10 00:00:00
abstract::Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90097-0
更新日期:1984-10-08 00:00:00
abstract::Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90900-8
更新日期:1994-04-11 00:00:00
abstract::Rats received a unilateral lesion of the nucleus basalis magnocellularis (NBM) by infusion of ibotenic acid. Starting 2 weeks after the lesion, the animals were treated with nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) by intraparenchymal infusion of 3 micrograms per day for 4 weeks. Lesioned ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91775-2
更新日期:1994-03-07 00:00:00
abstract::The discovery of glucagon biosynthesis and receptors within mammalian brain has led one to suspect a neurotransmitter role for glucagon. In order to address this hypothesis in birds, we investigated the existence of glucagon receptors in duck brain by radioligand binding on fresh tissue sections and radioautography. S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90469-3
更新日期:1994-11-07 00:00:00
abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03282-1
更新日期:2002-10-25 00:00:00
abstract::Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.090
更新日期:2008-11-13 00:00:00
abstract::The retrorubral field (RRF) contains numerous dopaminergic neurons and projects to the parvicellular reticular formation (RFp) of the medullary and pontomedullary brainstem, where many premotor neurons project to the orofacial motor nuclei. To know how the amygdala affects the RRF-RFp pathway in the rat, we first exam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.118
更新日期:2010-01-08 00:00:00
abstract::The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.070
更新日期:2008-11-25 00:00:00
abstract::The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00923-2
更新日期:1997-11-14 00:00:00
abstract::The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.044
更新日期:2007-07-09 00:00:00
abstract::We examined the effect of long-term exposure to radio frequency radiation 147 MHz and its sub-harmonics 73.5 and 36.75 MHz amplitude modulated at 16 and 76 Hz (30-35 days, 3 h per day) on cholinergic systems in developing rat brain. A significant decrease in acetylcholine esterase activity was found in exposed rats as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91729-c
更新日期:1993-01-22 00:00:00
abstract::In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03043-2
更新日期:2001-01-05 00:00:00