Abstract:
:In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction was observed only in rats treated with tPA at 6 h at the rate of 50%. In this delayed treatment group, significantly increased numbers of polymorphonuclear leukocytes (PMNL) were observed to accumulate inside microvessels within the ischemic core. PMNL accumulation may be related to the induction of hemorrhagic infarction after delayed tPA treatment.
journal_name
Brain Resjournal_title
Brain researchauthors
Kano T,Katayama Y,Tejima E,Lo EHdoi
10.1016/s0006-8993(99)02276-3subject
Has Abstractpub_date
2000-01-31 00:00:00pages
245-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02276-3journal_volume
854pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Neurofilaments were assembled in vitro from the high speed supernatant of mammalian CNS homogenate in a disassembly buffer containing 4-morpholine-ethane sulfonic acid, MgCl2 and EGTA at 4 degrees C in the presence of 4 M glycerol. The assembled neurofilaments were depolymerized by dialysis against the disassembly buf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(87)80010-0
更新日期:1987-07-01 00:00:00
abstract::The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.076
更新日期:2014-12-10 00:00:00
abstract::The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. CSF production was measured by the ventriculo-cisternal perfusion method with Blue dextran 2000 used as an indicat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91027-c
更新日期:1992-10-23 00:00:00
abstract::The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90566-1
更新日期:1975-10-10 00:00:00
abstract::Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00329-1
更新日期:1998-06-08 00:00:00
abstract::Previous studies using the spin trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) and the antioxidant vitamin E established the involvement of free radicals in kainic acid (KA)-induced neurotoxicity. In the present study, we examined the effects of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03034-8
更新日期:2003-08-15 00:00:00
abstract::Epileptiform activity induced by 4-AP in hippocampal area CA1 is characterised by short recurrent discharges. These are occasionally superimposed by slow field potential (fp) shifts. Simultaneous recordings of fps and [K(+)](o) in area CA1 and temporal cortex showed a slow fp shift in both regions, but associated rise...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03541-2
更新日期:2002-11-22 00:00:00
abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91081-3
更新日期:1993-10-22 00:00:00
abstract::Perinatal asphyxia to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term born infants with hypoxic-ischemic encephalopathy, saving one in seven to eight infants from developing severe neurological deficits. Therefore, addi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.040
更新日期:2016-09-01 00:00:00
abstract::Chronic administration of guanethidine to adult rats induces a selective autoimmune adrenergic neuropathy. Physiological and biochemical features of this disorder in the peripheral nervous system were explored in young adult Sprague-Dawley rats given daily intraperitoneal guanethidine monosulfate for 5 weeks. Control ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90720-2
更新日期:1988-09-27 00:00:00
abstract::Previous studies in this laboratory have demonstrated that cholinergic receptors within the spinal cord play an important role in the expression of naloxone-precipitated withdrawal symptoms in the morphine-dependent rat. Related cardiovascular studies in non-dependent animals have demonstrated that this spinal choline...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00203-3
更新日期:1995-05-15 00:00:00
abstract::Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90194-r
更新日期:1993-07-09 00:00:00
abstract::Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2020.146864
更新日期:2020-08-01 00:00:00
abstract::Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90192-6
更新日期:1986-01-01 00:00:00
abstract::Exposure of organotypic dorsal root ganglion-spinal cord cultures to taxol, a potent microtubule promoting and stabilizing agent, results in an unusual abundance of microtubules in neurons, and the presence of microtubule-endoplasmic reticulum arrays in their perikarya and processes. Ordered concentric arrays of micro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90017-2
更新日期:1981-08-03 00:00:00
abstract::Microinjection of bicuculline (Bic) into the unilateral putamen (Put) of the cat resulted in periodic occurrence of contralateral movement of the head (dystonia). Corresponding to this dystonic movement, repetitive spikes of the field potential occurring in the Put of the injected side and strong inhibition of the ext...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00190-2
更新日期:1995-04-24 00:00:00
abstract::Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.04.035
更新日期:2014-06-20 00:00:00
abstract::Cortical superfusion with 6-aminomethyl-3-methyl, 1-4H-1,2,6-benzothiadiazine-1,1-diazide hydrocholoride (TAG) at a concentration which selectively blocks taurine (Tau) action fails to modify electroencephalographic (EEG) activity, cortical neuronal firing and caudate-induced inhibition of cortical neuronal activity. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91449-6
更新日期:1986-08-13 00:00:00
abstract::In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91500-e
更新日期:1992-11-27 00:00:00
abstract::Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.033
更新日期:2018-09-15 00:00:00
abstract::Light stimulates dopamine (DA) release in the retina. The purpose of this study was to determine the threshold and dose-response relationship between ocular light exposure and retinal DA synthesis in vivo. Groups of dark-adapted rats were exposed to 0, 1, 3, 5, 10, 25, 50, 100 or 1000 microwatts per square centimeter ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91211-x
更新日期:1987-10-20 00:00:00
abstract::The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90227-0
更新日期:1984-06-11 00:00:00
abstract::The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90244-7
更新日期:1987-09-08 00:00:00
abstract::Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2010.11.094
更新日期:2011-03-16 00:00:00
abstract::Dendrites were transected 100 microns from nerve cell somata. The probability of cell survival increased as a function of the extent of proximal segment retraction. The retraction effect is probably the result of increased resistance to calcium and sodium currents at the lesion. It is speculated that limitation of ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90526-9
更新日期:1987-11-10 00:00:00
abstract::Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90494-5
更新日期:1988-08-16 00:00:00
abstract::Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferenc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90737-x
更新日期:1981-01-26 00:00:00
abstract::The properties of 5 beta-reductase, 5 alpha-reductase and aromatase, 3 testosterone metabolizing enzymes, were studied in the quail brain by an in vitro incubation technique. The results describe the changes in time of metabolite production and the effects of temperature, enzyme and cofactor concentrations. The appare...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91118-1
更新日期:1984-07-02 00:00:00
abstract::Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.092
更新日期:2011-04-28 00:00:00
abstract::An increase in medial perforant synaptic strength can be observed for hippocampal slices from rats exposed to environmental enrichment. The expression of enhanced synaptic strength exhibits properties similar to long-term potentiation (LTP), a physiological model of memory storage. Similarities include an increase in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00707-x
更新日期:1996-10-14 00:00:00