In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS.

abstract：:Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1984-03-19 00:00:00

abstract：:The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approxi...

journal_title：Brain research

authors： Singh NA,Bush LG,Gibb JW,Hanson GR

更新日期：1992-02-07 00:00:00

abstract：:Poor sleep and insomnia have been recognized to be strongly correlated with the development of depression. The exploration of the basic mechanism of sleep disturbance could provide the basis for improved understanding and treatment of insomnia and prevention of depression. In this study, 31 subjects with insomnia symp...

journal_title：Brain research

authors： Liu CH,Liu CZ,Zhang J,Yuan Z,Tang LR,Tie CL,Fan J,Liu QQ

更新日期：2016-10-01 00:00:00

abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...

journal_title：Brain research

authors： Rabey JM,Passeltiner P,Bystritsky A,Engel J,Goldstein M

更新日期：1981-12-28 00:00:00

abstract：:The caudodorsal cells (CDCs) of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying associated behaviours by releasing various peptides including the ovulation hormone CDCH. Previously it has been shown that release occurs (1) into the haemolymph from neurohaemal axon terminals in the outer compar...

journal_title：Brain research

authors： Schmidt ED,Roubos EW

更新日期：1989-06-12 00:00:00

abstract：:Spontaneous alternation which is disrupted by lesion of septal dopaminergic (DA) afferents was chosen as a behavioral marker for the study of functional interactions between DA and noradrenergic (NA) innervation of the lateral septum. Three groups of rats were studied: a solvent group which received only vehicle injec...

journal_title：Brain research

authors： Taghzouti K,Le Moal M,Simon H

更新日期：1991-06-21 00:00:00

abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

journal_title：Brain research

authors： Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

更新日期：1999-11-20 00:00:00

abstract：:Spontaneous, synchronous burst discharges originating in the CA2-CA3 region of guinea pig hippocampal slices occur when the concentration of magnesium in the perfusate is reduced below 250 microM. The burst frequency is greater than that seen with other convulsants and afterdischarge is common. Cyclic periods of burst...

journal_title：Brain research

authors： Schneiderman JH,MacDonald JF

更新日期：1987-04-28 00:00:00

abstract：:Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical applic...

journal_title：Brain research

authors： Regli L,Anderson RE,Meyer FB

更新日期：1994-11-28 00:00:00

abstract：:We sought to characterize regional heterogeneity of astrocytes using adrenergic receptor sites as cellular markers. Primary cultures made from 6 regions of neonatal rat brain consisted almost exclusively of astrocytes. Membranes from astrocytes cultured 1-3 weeks were prepared for radioligand binding assays of beta- a...

journal_title：Brain research

authors： Ernsberger P,Iacovitti L,Reis DJ

更新日期：1990-05-28 00:00:00

abstract：:The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

journal_title：Brain research

authors： Rasmussen K,Strecker RE,Jacobs BL

更新日期：1986-03-26 00:00:00

abstract：:Neurotrophins are potent regulators of the survival of different neuronal populations in the CNS. Little is known of the immunodistribution of neurotrophin-3 (NT-3) and tyrosine kinase C (TrkC) receptor in the frog visual system, which can successfully regenerate and recover vision after injury. In this study we show ...

journal_title：Brain research

authors： Duprey-Díaz MV,Blagburn JM,Blanco RE

更新日期：2003-08-22 00:00:00

abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...

journal_title：Brain research

authors： Kreuter J,Alyautdin RN,Kharkevich DA,Ivanov AA

更新日期：1995-03-13 00:00:00

abstract：:The ionic basis of norepinephrine (NE) action was studied with intracellular recording techniques in the rat hippocampal slice. Topical application of NE caused, in CA1 neurons, a 3-4 mV hyperpolarization associated with a 10-20% decrease in input resistance. This effect was accompanied by a decrease in spontaneous ac...

journal_title：Brain research

authors： Segal M

更新日期：1981-02-09 00:00:00

abstract：:Brain and anterior pituitary growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) were measured during fetal, neonatal, and pubertal life and into adulthood. Immunoassayable GH and TSH could be found in the fetal whole brain before their detection in the fetal pituitary. Developmental pa...

journal_title：Brain research

authors： Hojvat S,Emanuele N,Baker G,Connick E,Kirsteins L,Lawrence AM

更新日期：1982-08-01 00:00:00

abstract：:The distribution of cells expressing mu-receptor mRNA and mu-receptor binding sites were compared in brain and spinal cord tissue sections using a combination of in situ hybridization and receptor autoradiographic techniques. mu-Receptor mRNA was visualized with a 35S-labeled cRNA probe directed to transmembrane III-V...

journal_title：Brain research

authors： Mansour A,Fox CA,Thompson RC,Akil H,Watson SJ

更新日期：1994-04-18 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...

journal_title：Brain research

authors： Matsuda S,Desaki J,Okumura N,Shiosaka S,Imaoka S,Sakanaka M

更新日期：1992-04-10 00:00:00

abstract：:The neurotoxic compound 2,5-hexanedione (2,5-HD) causes an axonopathy characterized by the presence of neurofilament (NF)-containing enlargements in the preterminal segments of central and peripheral axons. The 2,5-HD axonopathy is a good model for human acquired and inherited giant axonal neuropathies. Recently, we r...

journal_title：Brain research

authors： Monaco S,Jacob J,Jenich H,Patton A,Autilio-Gambetti L,Gambetti P

更新日期：1989-07-10 00:00:00

abstract：:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...

journal_title：Brain research

authors： Suon S,Yang M,Iacovitti L

更新日期：2006-08-23 00:00:00

abstract：:The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-...

journal_title：Brain research

authors： Shippenberg TS,Bals-Kubik R,Herz A

更新日期：1987-12-15 00:00:00

abstract：:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...

journal_title：Brain research

authors： Ault B,Caviedes P,Rapoport SI

更新日期：1989-04-17 00:00:00

abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

journal_title：Brain research

authors： Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

更新日期：1993-04-02 00:00:00

abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...

journal_title：Brain research

authors： Welton J,Stewart W,Kerr R,Maxwell DJ

更新日期：1999-01-30 00:00:00

abstract：:Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...

journal_title：Brain research

authors： Holbrook PG,Baum MJ

更新日期：1983-03-01 00:00:00

abstract：:Preconditioning describes a variety of treatments that induce neurons to become more resistant to a subsequent ischemic insult. How preconditioned neurons adapt to subsequent ischemic stress is not fully understood, but is likely to involve multiple protective mechanisms. We hypothesized hypoxic preconditioning induce...

journal_title：Brain research

authors： Arthur PG,Lim SC,Meloni BP,Munns SE,Chan A,Knuckey NW

更新日期：2004-08-13 00:00:00

abstract：:Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunof...

journal_title：Brain research

authors： Ichikawa H,Sugimoto T

更新日期：2003-06-06 00:00:00

abstract：:Deferoxamine (DFO) has shown therapeutic promise for the treatment of Parkinson׳s disease (PD) as it has reduced both behavioral and biochemical deficits when injected into the brain of rodent models of PD. Intranasally administered DFO targets the brain directly but non-invasively and has been effective in animal mod...

journal_title：Brain research

authors： Fine JM,Forsberg AC,Renner DB,Faltesek KA,Mohan KG,Wong JC,Arneson LC,Crow JM,Frey WH 2nd,Hanson LR

更新日期：2014-07-29 00:00:00

abstract：:We have investigated the effects of nerve growth factor (NGF, 2.5 ng/ml for 1-2 weeks) on enriched adult rat dorsal root ganglion (DRG) neurons maintained in cell culture in defined media. Whole-cell recordings in cells cultured in the absence and presence of NGF revealed no significant difference in resting membrane ...

journal_title：Brain research

authors： Aguayo LG,White G

更新日期：1992-01-20 00:00:00

abstract：:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed...

journal_title：Brain research

authors： Birrell GJ,Marcoux FW

更新日期：1993-04-02 00:00:00

abstract：:Stereotaxic microinjections of the excitotoxin, ibotenic acid, were made into the striatum, hippocampus or cerebellum of the immature (7-day-old) rat. Two days later, pups were decapitated and the brains processed for light microscopic examination or neurochemical analyses. 10 micrograms ibotenate caused a complete lo...

journal_title：Brain research

authors： Steiner HX,McBean GJ,Köhler C,Roberts PJ,Schwarcz R

更新日期：1984-07-30 00:00:00