Abstract：
:Brain and anterior pituitary growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) were measured during fetal, neonatal, and pubertal life and into adulthood. Immunoassayable GH and TSH could be found in the fetal whole brain before their detection in the fetal pituitary. Developmental patterns of pituitary and brain hormones differed in that pituitary hormones showed a gradual rise in levels from birth to puberty at approximately 20 days of age. Biochemically similar, brain-based peptides demonstrated a remarkable preparturitional surge in concentrations that was limited to a few days immediately preceding birth. Twenty-four hours after birth, brain GH, TSH, and LH had dropped to levels equal to or less than concentrations in the neonatal pituitary and subsequently rose to adult levels around the time of puberty. In these studies it could be shown that both the placental-fetal barrier and the neonatal blood-brain barrier were intact. These observations indicate the presence of two biochemically and immunologically similar but topographically distinct pools of peptides present in the developing brain and in the anterior pituitary gland.
journal_name
Brain Resjournal_title
Brain researchauthors
Hojvat S,Emanuele N,Baker G,Connick E,Kirsteins L,Lawrence AMdoi
10.1016/0165-3806(82)90186-9subject
Has Abstractpub_date
1982-08-01 00:00:00pages
427-34issue
4eissn
0006-8993issn
1872-6240journal_volume
256pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:Electrical synaptic transmission via gap junctions has become an accepted feature of neuronal communication in the mammalian brain, and occurs often between dendrites of interneurons in major brain structures, including the hippocampus. Electrical and dye-coupling has also been reported to occur between pyramidal cell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.064
更新日期：2012-12-03 00:00:00
abstract：:Rats provided limited daily access to cocaine (1 h) maintain stable levels of drug self-administration over time while those switched to longer access (6 h or more) exhibit escalating patterns of drug intake. These results are reminiscent of human recreational and compulsive drug-taking behavior, respectively. We foun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.053
更新日期：2004-01-02 00:00:00
abstract：:The effects of different adrenoceptor agonists were investigated on mechanically induced Ca2+ waves in astroglial cells in astroglial-neuronal mixed cultures from rat hippocampus. In the initial part of the study some properties of the waves were characterized. The results show that the initiation of the Ca2+ waves wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00151-6
更新日期：1998-05-18 00:00:00
abstract：:Effects of intracranial self-stimulation of central 'punishment areas' were studied on an operant conditioning of vertical eye movements in the midpontine pretrigeminal cats as well as in the encéphale isolé cats. In 36 pretrigeminal cats, the ventromedial hypothalamus (VMH), basal amygdaloid nuclei (AMY), dorsal cent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91008-8
更新日期：1981-12-21 00:00:00
abstract：:Basic fibroblast growth factor (b-FGF) and alpha melanocyte stimulating hormone (alpha-MSH) were tested for their ability to promote axonal elongation on E14 fetal rat spinal cord cell culture, and to support cell survival. A similar development of neurite was observed in alpha-MSH treated cultures or in control cultu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90494-4
更新日期：1994-08-22 00:00:00
abstract：:Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.027
更新日期：2011-03-25 00:00:00
abstract：:Noradrenergic, serotoninergic and peptidergic nerves have been demonstrated in perivascular plexuses of vasa nervorum of sympathetic, parasympathetic and somatic nerve trunks. 5-Hydroxytryptamine-, vasoactive intestinal polypeptide- and substance P-containing fibers were found by immunohistochemistry to variable exten...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90344-5
更新日期：1984-06-25 00:00:00
abstract：:The active and passive membrane properties of developing Purkinje neurons in control cultures and cultures chronically treated with 20 or 40 mM ethanol for 1 or 2 weeks were examined using whole-cell current-clamp techniques. The membrane properties were characterized by the features of the voltage responses evoked by...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90707-3
更新日期：1991-08-30 00:00:00
abstract：:The innervation of the tensor tympani muscle of the middle ear in Macaca fascicularis (cynomolgus monkey) was studied using the horseradish peroxidase (HRP) neural tracing technique. A compact column of small trigeminal motoneurons was labeled ipsilaterally following intramuscular application of HRP to the tensor tymp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91376-x
更新日期：1987-02-24 00:00:00
abstract：:The amplitude of anterior neocortical EEG slow-waves (0.5-4 Hz) measured during quiet waking, drowsy (WS) and synchronized sleep (S) states showed slow rhythmic oscillations in WS and S similar to those previously reported in midbrain reticular neurons (periods of 8-12 s). Abrupt changes in slow rhythms of unit discha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90153-1
更新日期：1983-06-20 00:00:00
abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91177-2
更新日期：1987-01-13 00:00:00
abstract：:The ability of embryonic hippocampal tissue to promote regeneration of cholinergic axons in the septohippocampal system has been studied in adult rats. Strips of embryonic hippocampus, taken from 7-40 mm rat fetuses, were implanted into a 2-3 mm wide cavity which completely transected the septal cholinergic axons inne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90893-3
更新日期：1981-04-06 00:00:00
abstract：:The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2011.12.017
更新日期：2012-02-09 00:00:00
abstract：:Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90290-9
更新日期：1988-08-30 00:00:00
abstract：:Platelet-derived growth factor-B (PDGF-B) is a growth factor that regulates cell migration, proliferation, and differentiation, and is involved in several physical and pathological processes. The overexpression of PDGF-B in glioma surgical samples revealed its effect on tumorigenesis. In this study, we determined that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.01.045
更新日期：2014-03-27 00:00:00
abstract：:The distribution of iron in the brain of a vocal learning parrot, the budgerigar (Melopsittacus undulatus), was examined using iron histochemistry. In mammals, iron is a highly specific stain for the dorsal and ventral pallidal subdivision as well as specific cell groups in the brainstem, including the substantia nigr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03110-9
更新日期：2001-12-07 00:00:00
abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.035
更新日期：2004-12-17 00:00:00
abstract：:The cholinergic agonist pilocarpine injected intraperitoneally (ip) increases mean arterial pressure (MAP) and superior mesenteric (SM) vascular resistance and reduces submandibular/sublingual gland (SSG) vascular resistance. In the present study, we investigated the effects of electrolytic lesions of the anteroventra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.071
更新日期：2005-09-07 00:00:00
abstract：:The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90701-3
更新日期：1987-05-12 00:00:00
abstract：:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.070
更新日期：2009-09-01 00:00:00
abstract：:Opioid modulation of calcium currents was studied in acutely dissociated rat basal forebrain neurons using the whole cell patch-clamp recording technique. The mu-opioid receptor agonist DAGO reversibly suppressed high-voltage activated calcium currents and slowed their rate of activation, while neither delta- nor kapp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00206-0
更新日期：1997-05-30 00:00:00
abstract：:Neurons in the polymorph layer of the hippocampal dentate hilus were found to be the cells of origin for ipsilateral association and commissural projections to the dentate gyrus. Both afferent systems terminate in the proximal one-third of the stratum moleculare. The polymorph layer is the primary target for noradrene...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90512-6
更新日期：1981-06-29 00:00:00
abstract：:In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.089
更新日期：2004-10-29 00:00:00
abstract：:Blink movement metrics were studied in three alert cynomolgus monkeys using electromagnetic search coils attached to the eyelids bilaterally. Monkey blinks averaged approximately 24 degrees. Down-phase peak velocities were approximately twice those of the corresponding up phases. Most blinks were symmetrical with clos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90869-o
更新日期：1993-04-23 00:00:00
abstract：:This study examined the behavioral effects of agents active at the gamma-aminobutyric acid (GABA(A)) receptor complex in the mouse staircase paradigm. The neuroactivesteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were compared with the benzodiazepine agonist clonazepam, the non-benz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02331-9
更新日期：2001-05-18 00:00:00
abstract：:In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00139-x
更新日期：1997-05-16 00:00:00
abstract：:The normal patterns of the occurrence of tryptophan, 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and monoamine oxidase (MAO) activity in chick brain during development were investigated. Tryptophan level in the brain on the 7th day of embryonic development was rather high and decreased gradually un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90183-3
更新日期：1975-08-15 00:00:00
abstract：:To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01121-3
更新日期：1997-01-16 00:00:00
abstract：:We studied seizures which were induced by a microinjection of kainic acid (KA) into the unilateral olfactory bulb (OB) in the rats. The first epileptiform discharge appeared in the OB, was then propagated to the amygdala and the hippocampus unilaterally, and finally propagated to the unilateral sensori-motor cortex. C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00626-2
更新日期：1995-09-25 00:00:00
