Abstract：
:Basic fibroblast growth factor (b-FGF) and alpha melanocyte stimulating hormone (alpha-MSH) were tested for their ability to promote axonal elongation on E14 fetal rat spinal cord cell culture, and to support cell survival. A similar development of neurite was observed in alpha-MSH treated cultures or in control cultures, with an axonal length ranging from 87.50 microns to 195.60 microns on day 3. Complete cell death occurred after 6 days of incubation. Whatever the concentration of b-FGF used (0.312-2.5 ng/ml), a significant increase (1.2- to 1.4-fold) in neurite length was observed, with neuronal survival up to 9 days.
journal_name
Brain Resjournal_title
Brain researchauthors
Peulve P,Laquerriere A,Hemet J,Tadie Mdoi
10.1016/0006-8993(94)90494-4subject
Has Abstractpub_date
1994-08-22 00:00:00pages
319-23issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90494-4journal_volume
654pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In auditory speech processing, phonological stress functions as an attention holding cue, which facilitates detection of mispronunciations and phonetic deviants in strong syllables as compared to weak ones. Whereas silent reading involves activation of phonological information including word stress, it is not clear wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.003
更新日期：2016-04-01 00:00:00
abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90389-s
更新日期：1990-12-24 00:00:00
abstract：:Changes in the expression and activation of protein kinase C (PKC) have been implicated in the pathogenesis of diabetic neuropathy. Recent studies in liver, retina, and cardiovascular tissues from experimentally diabetic rats have demonstrated that diabetes has a selective effect on the expression and subcellular dist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00062-0
更新日期：1997-04-18 00:00:00
abstract：:Vascular permeability and intravascular space in the rat cerebral cortex and hypothalamus were assessed 5 and 14 days after the production of either right or left hemisphere frontal cortical suction lesions. Rats were intravenously injected with large (dextran, 50,000 kdalton) and small (inulin, 5000 kdalton) molecula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91414-3
更新日期：1985-12-16 00:00:00
abstract：:Temporal changes in cholinergic functions following transient cerebral ischemia (10 min) were studied in the hippocampus of awake unrestrained gerbils using in vivo microdialysis. These data were compared with the results for temporal change in the area of each CA1 cell soma, measured with a microcomputer imaging devi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91765-5
更新日期：1994-03-07 00:00:00
abstract：:The existence of spinal neuron collaterals projecting to the intralaminar thalamic nuclei (ILN) and the periaqueductal gray (PAG) was determined in the rat using double-labeling, fluorescent, retrograde axoplasmic transport techniques. Distinctively double-labeled neurons, although not numerous, were found in the enti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90731-6
更新日期：1986-02-12 00:00:00
abstract：:Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.090
更新日期：2008-01-16 00:00:00
abstract：:Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91202-r
更新日期：1990-01-01 00:00:00
abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91274-v
更新日期：1993-08-06 00:00:00
abstract：:A large body of evidence shows that methamphetamine (METH) causes sustained damage to the brain in animal models and human METH users. In chronic users there are indications of cognitive and motor deficits. Striatal neuropeptides are in a position to modulate the neurochemical effects of METH and consequently striatal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.010
更新日期：2013-05-13 00:00:00
abstract：:One model useful for demonstrating axonal regeneration in the central nervous system is that in which peripheral tissue, particularly the iris, is implanted into the brain or spinal cord. The aim of the present study was to establish the origin of some of the regenerating fibers by the use of an autoradiograhic tracin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91121-x
更新日期：1980-09-22 00:00:00
abstract：:Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.04.020
更新日期：2019-08-15 00:00:00
abstract：:A Rous Sarcoma virus transformed cerebellar cell line, BC6, secretes a factor which causes clonal glial cell lines to rapidly (1 h) extend processes. The factor shows a degree of specificity since only 3 out of 10 lines which exhibit either glial or combined glial and neuronal properties respond. The active factor app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90214-6
更新日期：1983-12-01 00:00:00
abstract：:Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00578-7
更新日期：1997-09-05 00:00:00
abstract：:Nerve-evoked muscle depolarisation plays an important role in the downregulation of extrasynaptic AChRs which accompanies the increase in synaptic AChR expression at the neuromuscular junction during embryonic development. However, additional mechanisms may be involved in the AChR downregulation. This study provides e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01313-4
更新日期：1999-02-13 00:00:00
abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.011
更新日期：2016-06-15 00:00:00
abstract：:Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90333-4
更新日期：1981-11-23 00:00:00
abstract：:The distribution of carnosine-like immunoreactivity in photoreceptors of the frog retina was studied by post-embedding electron microscope immunocytochemistry. Different fixation and embedding procedures were applied and the best results were achieved on sections from tissue embedded in the hydrophilic resin LR White....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90256-9
更新日期：1992-04-24 00:00:00
abstract：:A series of experiments was performed to determine the effects of the alpha 1-noradrenergic antagonist, prazosin, on the concentration of estrogen receptors in female rat brain and pituitary gland. Prazosin caused a dose-dependent decrease in the concentration of cytosol estrogen receptors in mediobasal hypothalamus w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91353-9
更新日期：1987-02-24 00:00:00
abstract：:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02553-7
更新日期：2001-07-06 00:00:00
abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90993-9
更新日期：1978-11-17 00:00:00
abstract：:Agents such as 619C89 decrease extracellular glutamate concentrations by a primary action at voltage sensitive sodium channels, but NMDA antagonists also have been shown to decrease extracellular glutamate concentration after ischemia. To address the question as to whether 619C89's effect upon extracellular glutamate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00868-q
更新日期：1995-11-13 00:00:00
abstract：:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03178-5
更新日期：2002-10-04 00:00:00
abstract：:Oxidative stress has been implicated as a pathogenic mediator of neuronal perikarya cell death. Axons and oligodendrocytes, components of white matter, could also be vulnerable to oxidative damage. An experimental model of oxidative stress was induced by systemic injection of 3-nitropropionic acid (3-NPA). Animals rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03266-2
更新日期：2001-02-23 00:00:00
abstract：:The amount of estradiol benzoate with progesterone required to induce lordosis in ovariectomized hamsters was determined to compare the responsiveness of hamsters to estradiol benzoate with that of rats and guinea pigs. In addition, the uptake and metabolism of tritiated estradiol in ovariectomized rats, guinea pigs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(74)90193-0
更新日期：1974-05-10 00:00:00
abstract：:A role for glutamatergic signaling in the nucleus accumbens (NA) in both the expression and extinction of cocaine seeking has been suggested. The effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of GluR1 and NMDAR1 glutamate receptor subunits in the NA shell a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.047
更新日期：2009-04-24 00:00:00
abstract：:Axonal and glial cell development within rat optic nerve in which gliogenesis was altered by systemic injection of 5-azacytidine (5-AZ) was examined by quantitative electron microscopy. In neonatal (0-2 days) rat optic nerves, all fibers are premyelinated, and they exhibit a fairly uniform diameter (approximately 0.22...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91436-8
更新日期：1986-08-13 00:00:00
abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00074-1
更新日期：1996-05-20 00:00:00
abstract：:The stimulatory effect of insulin-like growth factor I (IGF-I) on myelin basic protein (MBP) expression, a parameter for oligodendrocyte development, is mediated by the MAPK and PI3K signaling pathways. We have previously shown that the second messenger cAMP inhibits IGF-I-induced MAPK activation as well as MBP expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.018
更新日期：2007-10-31 00:00:00
abstract：:c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02943-8
更新日期：2002-09-06 00:00:00
