Abstract：
:One model useful for demonstrating axonal regeneration in the central nervous system is that in which peripheral tissue, particularly the iris, is implanted into the brain or spinal cord. The aim of the present study was to establish the origin of some of the regenerating fibers by the use of an autoradiograhic tracing technique. Briefly, iris implants were inserted in the caudal mesencephalon in the region of the dorsal tegmental bundle in unilaterally sympathectomized rats. Approximately two weeks later, subjects were injected with [3H]leucine in the region of the ipsilateral locus coeruleus and sacrificed two days later. Numerous labeled fibers were observed within the implants and traversing between brain and implant. Fibers formed loose plexuses, coursed along smooth muscle and grew toward blood vessels within the implants. These results may be added to fluorescent histochemical, biochemical and ultrastructural evidence supporting the regenerative capacity of central noradrenergic fibers.
journal_name
Brain Resjournal_title
Brain researchauthors
Schonfeld AR,Katzman Rdoi
10.1016/0006-8993(80)91121-xsubject
Has Abstractpub_date
1980-09-22 00:00:00pages
355-63issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(80)91121-Xjournal_volume
197pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03616-8
更新日期：2002-12-06 00:00:00
abstract：:Focal electrical stimulation and glutamate microinjection in the nuclei reticularis gigantocellularis (NGC) and gigantocellularis pars alpha (NGC alpha) both inhibit the nociceptive tail-flick (TF) reflex in rats. The present experiments were undertaken to determine the transmitter(s) at the level of the lumbar spinal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91825-2
更新日期：1990-12-03 00:00:00
abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02617-3
更新日期：2002-07-12 00:00:00
abstract：:Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90451-2
更新日期：1985-12-02 00:00:00
abstract：:Five normal rats and four rats with bilateral lesions of auditory cortex were tested by the conditioned suppression procedure to determine their abilities to discriminate between spatially separated sound sources. The discrimination involved detection of a change in location of a train of clicks from a speaker on the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90865-x
更新日期：1978-04-28 00:00:00
abstract：:The spiral ganglion accommodates the cell bodies of the acoustic nerve fibres connecting the hair cells to the central nervous system. As the ionic channels containing various voltage-gated K+ channel (Kv) subunits play pivotal roles in determining the functional properties and firing behaviour of the spiral ganglion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.072
更新日期：2008-05-19 00:00:00
abstract：:Fetal exposure to diazepam (DZ), a positive modulator of GABA(A) receptors and an agonist at mitochondrial benzodiazine receptors, induces long-term neural and behavioral effects. This study evaluated whether the early manipulation influenced the normal development of brain levels of neurosteroids or altered steroid a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.039
更新日期：2006-01-05 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：:Extracellular microelectrode recordings were made from a total of 868 neurons in the medullas of cats in regions known to contain high densities of respiratory-related neurons (solitary tract complex, nucleus ambiguus/retroambigualis, lateral tegmental field). Both the discharge patterns and the locations of units wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90979-x
更新日期：1984-03-19 00:00:00
abstract：:Nestin is an embryonic intermediate filament that transiently expressed in the neural stem/progenitor cells in the developing central nervous system (CNS). Growing evidence has shown that abundant expression of nestin also occurs in both pathological glial-derived tumor cells and reactive astrocytes in various CNS inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.026
更新日期：2008-02-27 00:00:00
abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90360-0
更新日期：1989-04-10 00:00:00
abstract：:Individuals are found to have better recall for self-referent information than other types of information. However, attribution research has shown that self-reference is highly correlated with emotional valence. The present study attempted to identify and separate the processing of self-reference and emotional valence...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.049
更新日期：2007-06-04 00:00:00
abstract：:The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90316-f
更新日期：1993-09-03 00:00:00
abstract：:The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90791-9
更新日期：1990-10-29 00:00:00
abstract：:A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding prote...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.05.052
更新日期：2014-10-10 00:00:00
abstract：:The involvement of the dopaminergic pathway from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc) in the reinforcing properties of many drugs of abuse is well established. Though the prefrontal cortex (PFC) exhibits significant influence over activity in this pathway, its role in drug abuse is less def...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.003
更新日期：2006-02-23 00:00:00
abstract：:Finger representation on the first somatosensory cortex was mapped in conscious monkeys by single-unit recording. While representation was somatotopic in area 3, this was not the case in area 2, where the representation of different fingers overlapped. Our results indicate that area 2 is not a pure replica of the rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91139-7
更新日期：1980-09-22 00:00:00
abstract：:The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91983-6
更新日期：1994-11-21 00:00:00
abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02086-8
更新日期：2001-04-06 00:00:00
abstract：:Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01082-3
更新日期：1999-03-13 00:00:00
abstract：:Pars interpolaris of the spinal trigeminal nucleus of kittens has been studied with the electron microscope at birth and at several subsequent ages during the first month of life. Attention has been given to ultrastructural maturational changes that occur in this neuropil, especially events in synaptogenesis. The resu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90354-2
更新日期：1978-03-31 00:00:00
abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.092
更新日期：2007-12-14 00:00:00
abstract：:Two categories of large neurons--fusiform cells and giant cells--can be distinguished in the dorsal cochlear nucleus of the hamster. In the adult, these neurons are located in separate laminae in the nucleus and have distinct dendritic morphology. However, the two cell types are not distinguishable in the newborn hams...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90088-4
更新日期：1985-05-01 00:00:00
abstract：:The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.016
更新日期：2004-09-03 00:00:00
abstract：:The effect of the non-phenothiazine calmodulin-inhibitor R 24571 on transmitter release at the frog neuromuscular junction has been investigated. MEPP frequency was reduced by 25-40% at low concentrations of the drug (2-5 X 10(-7) M) but increased at higher concentrations. These effects were independent of [Ca2+]o. EP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90379-8
更新日期：1985-11-25 00:00:00
abstract：:The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90128-5
更新日期：1989-12-25 00:00:00
abstract：:The biochemical changes associated with conduction block following exogenous application of purified phospholipase A2 to bullfrog sciatic nerves were investigated. Nerves were treated with concentrations of phospholipase A2 needed to produce at least a 50% decrease in the compound action potential after a 2-2 1/2 h in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90354-9
更新日期：1986-05-14 00:00:00
abstract：:Concurrent activation of dopamine D1 and D2 receptors (D1 and D2) is required for the expression of certain dopamine (DA)-mediated responses, such as climbing and stereotyped behaviors. Such interactions between D1 and D2 (i.e. D1/D2 synergism) represent an important aspect of dopaminergic function and plasticity. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04277-4
更新日期：2003-03-28 00:00:00
abstract：:The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90510-7
更新日期：1975-11-07 00:00:00
abstract：:Explosive running is a reliable initial component of audiogenic seizures (AS) induced by acoustic stimulation in genetically prone rodents. This profound locomotor activation is usually considered as a convulsive manifestation of AS although some studies attribute running to a panic-like response. Increase in central ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.017
更新日期：2007-05-07 00:00:00
