Chloride-dependent stimulation of GABA and benzodiazepine receptor binding by pentobarbital.

Abstract:

:Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pentobarbital on both [3H]GABA and [3H]flunitrazepam binding.

journal_name

Brain Res

journal_title

Brain research

authors

Asano T,Ogasawara N

doi

10.1016/0006-8993(81)90333-4

subject

Has Abstract

pub_date

1981-11-23 00:00:00

pages

212-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)90333-4

journal_volume

225

pub_type

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