Abstract：
:Binding sites of atrial natriuretic peptide in the cerebral microvessels and choroid plexus of spontaneously hypertensive rats (SHR) and Wistar Kyoto control rats (WKY) were measured. In the microvessels, the number of ANP binding sites was lower in SHR than WKY, but there was no difference in affinity of binding sites for the ligand between SHR and WKY. In the choroid plexus, the number of ANP binding sites was lower and the affinity for the ligand was higher in SHR than in WKY. These results suggest that the physiological function regulated by the ANP receptors in the cerebral microvessels and choroid plexus were altered in hypertension and that ANP receptors in the cerebral microvessels and choroid plexus were differentially regulated.
journal_name
Brain Resjournal_title
Brain researchauthors
Okazaki M,Kobayashi H,Kuroiwa A,Izumi Fdoi
10.1016/0006-8993(90)90984-jsubject
Has Abstractpub_date
1990-06-04 00:00:00pages
292-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(90)90984-Jjournal_volume
518pub_type
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